Background
Methods
Search strategy
Inclusion criteria and study selection
Data abstraction and quality assessment
Statistical analysis
Results
Search results
Clinical trial | Number of patients (G/C) | Mean age (G/C, yr) | Male/Female | anesthesia | Dose of gabapentin | Time to use the pregablin | Intraoperative analgesai | preoperative analgesia | Postoperative analgesics |
---|---|---|---|---|---|---|---|---|---|
Carmichael et al. [11] | 23/24 | 59.1/61.3 | 22/25 | spinal anesthetic | 75 mg twice per day | 2 weeks preoperative and for 3 weeks from the day of discharge | NS | 400 mg celecoxib, 150 mg pregabalin and 1 g of acetaminophen | * |
Clarke et al. [12] | 83/79 | 60.2/60.1 | 82/80 | spinal anesthesia | 150 mg/day | 2 h before surgery | Hypobaric bupivacaine 0.5 % (10 ml) with fentanyl 10 μg was injected | celecoxib | PCA |
Martinez et al. [14] | 35/38 | 64/64 | 45/28 | general anesthesia | 150 mg/day | before surgery | 0.2 lg.kg 1 sufentanil followed by 2 mg.kg 1 propofol and 0.5 mg.kg 1 | NS | PCA |
Mathiesen et al. [15] | 40/38 | 67/66 | 32/46 | spinal anesthesia | 300 mg/day | 1 h before anesthesia | 3 ml plain bupivacaine 5 mg ml | acetaminophen 1 g was given as premedication 1 h before anesthesia | PCA |
Rasmussen et al. [17] | 24/18 | 72/70 | 18/24 | spinal anesthesia | 1200 mg/day | 1 h before anesthesia | 3 ml plain bupivacaine (5mgml | NS | PCA |
Paul et al. [16] | 48/54 | 60.9/60.5 | 58/64 | spinal anesthesia | 600 mg/day | 2 h before surgery | fentanyl 20 lg and 0.5 % or 0.75 % of bupivacaine | NS | PCA |
Clarke et al. [13] | 78/39 | 58.9/61.3 60.4/61.3 | 49/45 | spinal anesthesia | 600 mg/day | 2 h before surgery | 15 mg of 0.5 % hypobaric bupivacaine with 10 mg of fentanyl | acetaminophen 1000 mg per (p.o.), celecoxib 400 mg p.o. and dexamethasone 8 mg iv | PCA |
Variables | Studies (n) | Patients (n) | p-value | Incidence | ||
---|---|---|---|---|---|---|
Mean difference (95 % CI) or risk ratio (95 % CI) | Heterogeneity p-value (I2) | Model | ||||
24 h cumulative consumption | ||||||
Overall | 5 | 540 | <0.001 | −7.82 (−0.95, −0.52) | <0.001 (87.2 %) | random |
Gabapentin | 3 | 300 | <0.001 | −2.65 (−3.67, −1.63) | 0.427 (0 %) | random |
Pregabalin | 2 | 240 | <0.001 | −19.42 (−11.72, −3.93) | <0.001 (59.9 %) | random |
48 h cumulative consumption | ||||||
Overall | 5 | 378 | 0.118 | −6.90 (−0.95, 0.57) | <0.001 (93.7 %) | random |
Gabapentin | 3 | 258 | 1.000 | 0.00 (−7.69, 7.69) | <0.001 (94.5 %) | random |
Pregabalin | 2 | 120 | <0.001 | −33.02 (−45.86, −20.19) | 0.989 (0.00 %) | random |
VAS score with rest at 24 h | ||||||
Overall | 5 | 451 | 0.360 | 0.15 (−0.17, −0.48) | 0.017 (63.7 %) | random |
Gabapentin | 3 | 300 | 0.076 | 0.32 (−0.03, 0.67) | 0.082 (55.3 %) | random |
Pregabalin | 2 | 151 | 0.486 | −3.05 (−11.63, 5.53) | 0.193 (41.1 %) | random |
VAS score with rest at 48 h | ||||||
Overall | 3 | 331 | 0.363 | 0.22 (−0.25, 0.69) | 0.003 (78 %) | random |
Gabapentin | 2 | 258 | 0.049 | 0.41 (0.00, 0.81) | 0.072 (62.1 %) | random |
Pregabalin | 1 | 73 | 0.106 | NS | NS | NS |
VAS score with mobilization at 24 h | ||||||
Overall | 5 | 451 | 0.164 | 0.46 (−0.19, 1.11) | <0.001 (91 %) | random |
Gabapentin | 3 | 300 | 1.137 | 0.72 (0.23, 1.66) | <0.001 (93.1 %) | random |
Pregabalin | 2 | 151 | 0.803 | −0.78 (−6.91, 5.35) | 0.799 (0 %) | random |
VAS score with mobilization at 48 h | ||||||
Overall | 3 | 331 | 0.193 | 1.15 (−0.58, 2.89) | <0.001 (97.8 %) | random |
Gabapentin | 2 | 258 | 0.045 | 1.90 (0.04, 3.75) | <0.001 (97.2 %) | random |
Pregabalin | 1 | 73 | <0.001 | NS | NS | NS |