nach oben

Tumor Biology

Erschienen in:

01.12.2015 | Review

The emerging role of Nemo-like kinase (NLK) in the regulation of cancers

verfasst von: Ying Huang, Yang Yang, Yong He, Jun Li

Erschienen in: Tumor Biology | Ausgabe 12/2015

Einloggen, um Zugang zu erhalten

Abstract

Nemo-like kinase (NLK) is an evolutionarily conserved mitogen-activated protein (MAP) kinase-related kinase that is highly expressed in neural tissues and minimally detected in others. Accumulating evidence demonstrates that NLK exerts a pivotal role in cell proliferation, migration, invasion, and apoptosis via regulation of a variety of transcriptional molecules. The results of recent studies have shown that aberrant expression of NLK is significantly associated with the initiation and progression of various types of human cancers, as well as clinicopathologic features and survival rate. NLK is gradually considered as a potential tumor suppressor or an oncogene depending on the tumor system, and silencing or upregulating of NLK may provide an effective therapeutic approach against tumors. In this review, we will make a summary on the comprehensive roles of NLK in the regulation of various cancers.

Choi KW. Rotation of photoreceptor clusters in the developing Drosophila eye requires the nemo gene. Cell. 1994;78:125–36.CrossRefPubMed

Brott BK. Nlk is a murine protein kinase related to Erk/MAP kinases and localized in the nucleus. Proc Natl Acad Sci U S A. 1998;95:963–8.CrossRefPubMedPubMedCentral

Katoh M. Comparative genomics on nemo-like kinase gene. Int J Oncol. 2005;26:1715–9.PubMed

Kortenjann M. Abnormal bone marrow stroma in mice deficient for nemo-like kinase Nlk. Eur J Immunol. 2001;31:3580–7.CrossRefPubMed

Ishitani T. Nemo-like kinase is involved in NGF-induced neurite outgrowth via phosphorylating MAP1B and paxillin. J Neurochem. 2009;111:1104–18.CrossRefPubMed

Xu D. Expression of Nemo-like kinase after spinal cord injury in rats. J Mol Neurosci. 2014;52:410–8.CrossRefPubMed

Ota S. NLK positively regulates Wnt/beta-catenin signalling by phosphorylating LEF1 in neural progenitor cells. EMBO J. 2012;31:1904–15.CrossRefPubMedPubMedCentral

Thorpe CJ. nemo-like kinase is an essential co-activator of Wnt signaling during early zebrafish development. Development. 2004;131:2899–909.CrossRefPubMed

Ishitani T. Nemo-like kinase, a multifaceted cell signaling regulator. Cell Signal. 2013;25:190–7.CrossRefPubMed

10.

Jung KH. Targeted disruption of Nemo-like kinase inhibits tumor cell growth by simultaneous suppression of cyclin D1 and CDK2 in human hepatocellular carcinoma. J Cell Biochem. 2010;110:687–96.CrossRefPubMed

11.

Li M. Prognostic significance of nemo-like kinase (NLK) expression in patients with gallbladder cancer. Tumour Biol. 2013;34:3995–4000.CrossRefPubMed

12.

Emami KH. Nemo-like kinase induces apoptosis and inhibits androgen receptor signaling in prostate cancer cells. Prostate. 2009;69:1481–92.CrossRefPubMedPubMedCentral

13.

Zhang Y. Expression of NLK and its potential effect in ovarian cancer chemotherapy. Int J Gynecol Cancer. 2011;21:1380–7.CrossRefPubMed

14.

Huang Y. Nemo-like kinase associated with proliferation and apoptosis by c-Myb degradation in breast cancer. PLoS One. 2013;8:e69148.CrossRefPubMedPubMedCentral

15.

Shaw-Hallgren G. Association of nuclear-localized Nemo-like kinase with heat-shock protein 27 inhibits apoptosis in human breast cancer cells. PLoS One. 2014;9:e96506.CrossRefPubMedPubMedCentral

16.

Lv L. Nemo-like kinase (NLK) inhibits the progression of NSCLC via negatively modulating WNT signaling pathway. J Cell Biochem. 2014;115:81–92.CrossRefPubMed

17.

Cui G. Clinical and biological significance of nemo-like kinase expression in glioma. J Clin Neurosci. 2011;18:271–5.CrossRefPubMed

18.

Han Y. NLK, a novel target of miR-199a-3p, functions as a tumor suppressor in colorectal cancer. Biomed Pharmacother. 2014.

19.

Chen J. Nemo-like kinase expression predicts poor survival in colorectal cancer. Mol Med Rep. 2015;11:1181–7.PubMed

20.

Tan Z. NLK is a key regulator of proliferation and migration in gallbladder carcinoma cells. Mol Cell Biochem. 2012;369:27–33.CrossRefPubMed

21.

Yasuda J. Nemo-like kinase induces apoptosis in DLD-1 human colon cancer cells. Biochem Biophys Res Commun. 2003;308:227–33.CrossRefPubMed

22.

Dong JR. Inhibition of nemo-like kinase increases taxol sensitivity in laryngeal cancer. Asian Pac J Cancer Prev. 2013;14:7137–41.CrossRefPubMed

23.

Kohlhapp FJ. MicroRNAs as mediators and communicators between cancer cells and the tumor microenvironment. Oncogene. 2015.

24.

Song JL. microRNA regulation of Wnt signaling pathways in development and disease. Cell Signal. 2015;27:1380–91.CrossRefPubMedPubMedCentral

25.

Chen Z. The pivotal role of microRNA-155 in the control of cancer. J Cell Physiol. 2014;229:545–50.CrossRefPubMed

26.

Ji J. Identification of microRNA-181 by genome-wide screening as a critical player in EpCAM-positive hepatic cancer stem cells. Hepatology. 2009;50:472–80.CrossRefPubMedPubMedCentral

27.

Wang K. miR-92b controls glioma proliferation and invasion through regulating Wnt/beta-catenin signaling via Nemo-like kinase. Neuro Oncol. 2013;15:578–88.CrossRefPubMedPubMedCentral

28.

Shen Q. MiR-101 functions as a tumor suppressor by directly targeting nemo-like kinase in liver cancer. Cancer Lett. 2014;344:204–11.CrossRefPubMed

29.

Zou D. MiR-197 induces Taxol resistance in human ovarian cancer cells by regulating NLK. Tumour Biol. 2015.

30.

Xu ZY. Knockdown of long non-coding RNA HOTAIR suppresses tumor invasion and reverses epithelial-mesenchymal transition in gastric cancer. Int J Biol Sci. 2013;9:587–97.CrossRefPubMedPubMedCentral

31.

Yang F. Long noncoding RNA CCAT1, which could be activated by c-Myc, promotes the progression of gastric carcinoma. J Cancer Res Clin Oncol. 2013;139:437–45.CrossRefPubMed

32.

Vernucci M. The H19 endodermal enhancer is required for Igf2 activation and tumor formation in experimental liver carcinogenesis. Oncogene. 2000;19:6376–85.CrossRefPubMed

33.

Du Y. Elevation of highly up-regulated in liver cancer (HULC) by hepatitis B virus X protein promotes hepatoma cell proliferation via down-regulating p18. J Biol Chem. 2012;287:26302–11.CrossRefPubMedPubMedCentral

34.

Hajjari M. HOTAIR: an oncogenic long non-coding RNA in different cancers. Cancer Biol Med. 2015;12:1–9.PubMedPubMedCentral

35.

Martens-Uzunova ES. Long noncoding RNA in prostate, bladder, and kidney cancer. Eur Urol. 2014;65:1140–51.CrossRefPubMed

36.

Zhang JX. HOTAIR, a cell cycle-associated long noncoding RNA and a strong predictor of survival, is preferentially expressed in classical and mesenchymal glioma. Neuro Oncol. 2013;15:1595–603.CrossRefPubMedPubMedCentral

37.

Zhou X. HOTAIR is a therapeutic target in glioblastoma. Oncotarget. 2015.

38.

Takebe N. Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways. Nat Rev Clin Oncol. 2011;8:97–106.CrossRefPubMed

39.

Gatcliffe TA. Wnt signaling in ovarian tumorigenesis. Int J Gynecol Cancer. 2008;18:954–62.CrossRefPubMed

40.

Ishitani T. Regulation of lymphoid enhancer factor 1/T-cell factor by mitogen-activated protein kinase-related Nemo-like kinase-dependent phosphorylation in Wnt/beta-catenin signaling. Mol Cell Biol. 2003;23:1379–89.CrossRefPubMedPubMedCentral

41.

Yasuda J. Mammalian Nemo-like kinase enhances beta-catenin-TCF transcription activity in human osteosarcoma and neuroblastoma cells. Proc Jpn Acad Ser B Phys Biol Sci. 2007;83:16–25.CrossRefPubMedPubMedCentral

42.

Quinn DI. Molecular markers of prostate cancer outcome. Eur J Cancer. 2005;41:858–87.CrossRefPubMed

43.

Bender TP. Critical functions for c-Myb at three checkpoints during thymocyte development. Nat Immunol. 2004;5:721–9.CrossRefPubMed

Titel: The emerging role of Nemo-like kinase (NLK) in the regulation of cancers
verfasst von: Ying Huang
Yang Yang
Yong He
Jun Li
Publikationsdatum: 01.12.2015
Verlag: Springer Netherlands
Erschienen in: Tumor Biology / Ausgabe 12/2015
Print ISSN: 1010-4283
Elektronische ISSN: 1423-0380
DOI: https://doi.org/10.1007/s13277-015-4159-7

Springer Medizin

The emerging role of Nemo-like kinase (NLK) in the regulation of cancers

Abstract

Neu im Fachgebiet Onkologie

Adjuvante Immuntherapie verlängert Leben bei RCC

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Update Onkologie

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 12/2015

MicroRNA-133a functions as a tumor suppressor by targeting IGF-1R in hepatocellular carcinoma

Up-regulation of annexin A2 expression predicates advanced clinicopathological features and poor prognosis in hepatocellular carcinoma

HPV-type-specific response of cervical cancer cells to cisplatin after silencing replication licensing factor MCM4

Erratum to: Strong expression of polypeptide N-acetylgalactosaminyltransferase 3 independently predicts shortened disease-free survival in patients with early stage oral squamous cell carcinoma

Long noncoding RNA HOTAIR, a hypoxia-inducible factor-1α activated driver of malignancy, enhances hypoxic cancer cell proliferation, migration, and invasion in non-small cell lung cancer

Association between cell cycle gene transcription and tumor size in oral squamous cell carcinoma

Neu im Fachgebiet Onkologie

Adjuvante Immuntherapie verlängert Leben bei RCC

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Update Onkologie