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Medical Oncology
Erschienen in: Medical Oncology 1/2010

01.06.2010 | Original Paper

The evolution and impact of therapy in multiple myeloma

verfasst von: Jacob P. Laubach, Paul G. Richardson, Kenneth C. Anderson

Erschienen in: Medical Oncology | Sonderheft 1/2010

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Abstract

Multiple myeloma is a clonal B-cell malignancy characterized by aberrant expression of plasma cells wtihin the bone marrow, and is associated with the well known clinical manifestations anemia, bone disease, renal dysfunction, hypercalcemia, and recurrent infections. For many years, melphalan and prednisone represented the standard of care in multiple myeloma therapy, with stem cell transplantation reserved for selected patients. Treatment of the disease has evolved rapidly over the past decade, however, with the development and utilization of thalidomide, lenalidomide, and bortezomib. As a result of these developments, clinical outcomes have improved significantly. This review highlights important historic landmarks as well as more recent events that have played an important role in the evolution of myeloma therapy.
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Metadaten
Titel
The evolution and impact of therapy in multiple myeloma
verfasst von
Jacob P. Laubach
Paul G. Richardson
Kenneth C. Anderson
Publikationsdatum
01.06.2010
Verlag
Springer US
Erschienen in
Medical Oncology / Ausgabe Sonderheft 1/2010
Print ISSN: 1357-0560
Elektronische ISSN: 1559-131X
DOI
https://doi.org/10.1007/s12032-010-9442-2

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