nach oben

Erschienen in:

01.03.2013 | Original Article

The fall rate of older community-dwelling cancer patients

verfasst von: Martine T. E. Puts, Johanne Monette, Veronique Girre, Christina Wolfson, Michèle Monette, Gerald Batist, Howard Bergman

Erschienen in: Supportive Care in Cancer | Ausgabe 3/2013

Einloggen, um Zugang zu erhalten

Abstract

Purpose

Little is known about the incidence of falls in cancer patients receiving cancer treatment. The aims were to explore the number of falls older adults report in the 6 months after cancer diagnosis, and if those with a fall were more frail than those who did not fall.

Methods

Secondary data analysis of a prospective pilot study that recruited patients aged 65 and older with a new cancer diagnosis. At each interview (baseline, 3- and 6-month follow-up), participants were asked if they had a fall in the previous 3 months. The frailty markers and functional status were obtained at baseline, 3- and 6-month follow-up. Chi-square and t tests were used to compare those who had a fall to those who had no fall. Univariate logistic regression analysis was conducted to explore the association between sociodemographic and health characteristics and reporting a fall.

Results

Seventeen participants (18.7 %) reported one or more falls in the first 6 months after cancer diagnosis. Fifteen participants reported one or more falls in the 3 months prior to the cancer diagnosis. Those who had a fall and those with no fall were not different in terms of health and functioning. None of the sociodemographic and health characteristics including the frailty markers were associated with a fall.

Conclusion

A fall is common in cancer patients. More research is needed to examine the risk factors for a fall in older adults receiving cancer treatment.

World Health Organization. WHO global report on falls prevention in older age. WHO Press, Geneva

Division of Aging and Seniors, Public Health Agency of Canada (2005) Report on seniors’ falls in Canada. Ottawa: Minister of Public Works and Government Services Canada

Smith BD, Smith GL, Hurria A, Hortobagyi GN, Buchholz TA (2009) Future of cancer incidence in the United States: burdens upon an aging, changing nation. J Clin Oncol 27(17):2758–2765PubMedCrossRef

Holley S (2002) A look at the problem of falls among people with cancer. Clin J Oncol Nurs 6(4):193–197PubMedCrossRef

Chen Z, Maricic M, Aragaki AK, Mouton C, Arendell L, Lopez AM, Bassford T, Chlebowski RT (2009) Fracture risk increases after diagnosis of breast or other cancers in postmenopausal women: results from the women’s health initiative. Osteoporos Int 20(4):527–536PubMedCrossRef

Tofthagen C, McAllister RD, McMillan SC (2011) Peripheral neuropathy in patients with colorectal cancer receiving oxaliplatin. Clin J Oncol Nurs 15(2):182–188PubMedCrossRef

Tofthagen C, Overcash J, Kip K (2012) Falls in persons with chemotherapy-induced peripheral neuropathy. Support Care Cancer 20(3):583–589PubMedCrossRef

DeMott TK, Richardson JK, Thies SB, Ashton-Miller JA (2007) Falls and gait characteristics among older persons with peripheral neuropathy. Am J Phys Med Rehabil 86(2):125–132PubMedCrossRef

Limburg CE (2007) Screening, prevention, detection, and treatment of cancer therapy-induced bone loss in patients with breast cancer. Oncol Nurs Forum 34(1):55–63PubMedCrossRef

10.

Bylow K, Hemmerich J, Mohile SG, Stadler WM, Sajid S, Dale W (2011) Obese frailty, physical performance deficits, and falls in older men with biochemical recurrence of prostate cancer on androgen deprivation therapy: a case–control study. Urology 77(4):934–940PubMedCrossRef

11.

Bylow K, Dale W, Mustian K, Stadler WM, Rodin M, Hall W, Lachs M, Mohile SG (2008) Falls and physical performance deficits in older patients with prostate cancer undergoing androgen deprivation therapy. Urology 72(2):422–427PubMedCrossRef

12.

Overcash J (2007) Prediction of falls in older adults with cancer: a preliminary study. Oncol Nurs Forum 34(2):341–346PubMedCrossRef

13.

Overcash JA, Beckstead J (2008) Predicting falls in older patients using components of a comprehensive geriatric assessment. Clin J Oncol Nurs 12(6):941–949PubMedCrossRef

14.

Hussain S, Breunis H, Timilshina N, Alibhai SMH (2010) Falls in men on androgen deprivation therapy for prostate cancer. J Geriatr Oncol 1(1):32–39CrossRef

15.

Stone C, Lawlor PG, Nolan B, Kenny RA (2011) A prospective study of the incidence of falls in patients with advanced cancer. J Pain Symptom Manag 42(4):535–540CrossRef

16.

Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, Seeman T, Tracy R, Kop WJ, Burke G, Mcburnie MA (2001) Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 56(3):M146–M156PubMedCrossRef

17.

Ensrud KE, Ewing SK, Cawthon PM, Fink HA, Taylor BC, Cauley JA, Dam TT, Marshall LM, Orwoll ES, Cummings SR, Osteoporotic Fractures in Men Research Group (2009) A comparison of frailty indexes for the prediction of falls, disability, fractures, and mortality in older men. J Am Geriatr Soc 57(3):492–498PubMedCrossRef

18.

Ensrud KE, Ewing SK, Taylor BC, Fink HA, Cawthon PM, Stone KL, Hillier TA, Cauley JA, Hochberg MC, Rodondi N, Tracy JK, Cummings SR (2008) Comparison of 2 frailty indexes for prediction of falls, disability, fractures, and death in older women. Arch Intern Med 168(4):382–389PubMedCrossRef

19.

Ensrud KE, Ewing SK, Taylor BC, Fink HA, Stone KL, Cauley JA, Tracy JK, Hochberg MC, Rodondi N, Cawthon PM, for the Study of Osteoporotic Fractures Research Group (2007) Frailty and risk of falls, fracture, and mortality in older women: the study of osteoporotic fractures. J Gerontol A Biol Sci Med Sci 62(7):744–751PubMedCrossRef

20.

Puts MT, Monette J, Girre V, Wolfson C, Monette M, Batist G, Bergman H (2009) Participation of older newly-diagnosed cancer patients in an observational prospective pilot study: an example of recruitment and retention. BMC Cancer 9(1):277PubMedCrossRef

21.

Bergman H, Ferrucci L, Guralnik J, Hogan DB, Hummel S, Karunananthan S, Wolfson C (2007) Frailty: an emerging research and clinical paradigm issues and controversies. J Gerontol A Biol Sci Med Sci 62(1079–5006; 7):731–737PubMedCrossRef

22.

Bergman H, Béland F, Karunananthan S, Hummel S, Hogan D, Wolfson C (2004) Développement d’un cadre de travail pour comprendre et étudier la fragilité. Gerontol Soc 109:15–29

23.

Perera S, Mody SH, Woodman RC, Studenski SA (2006) Meaningful change and responsiveness in common physical performance measures in older adults. J Am Geriatr Soc 54(0002–8614; 5):743–749PubMedCrossRef

24.

Guralnik JM, Simonsick EM, Ferrucci L, Glynn RJ, Berkman LF, Blazer DG, Scherr PA, Wallace RB (1994) A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol 49(2):M85–M94PubMedCrossRef

25.

Folstein MF, Folstein SE, McHugh PR (1975) “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12(3):189–198PubMedCrossRef

26.

Nasreddine ZS, Phillips NA, Bedirian V, Charbonneau S, Whitehead V, Collin I, Cummings JL, Chertkow H (2005) The Montreal cognitive assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc 53(0002–8614; 4):695–699PubMedCrossRef

27.

Zigmond AS, Snaith RP (1983) The hospital anxiety and depression scale. Acta Psychiatr Scand 67(0001–690; 6):361–370PubMedCrossRef

28.

Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ, Filiberti A, Flechtner H, Fleishman SB, de Haes JC (1993) The European organization for research and treatment of cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst 85(5):365–376PubMedCrossRef

29.

Rantanen T, Guralnik JM, Foley D, Masaki K, Leveille S, Curb JD, White L (1999) Midlife hand grip strength as a predictor of old age disability. JAMA 281(6):558–560PubMedCrossRef

30.

Davis HS, MacPherson K, Merry HR, Wentzel C, Rockwood K (2001) Reliability and validity of questions about exercise in the Canadian study of health and aging. Int Psychogeriatr 13(Supp 1(1041–6102)):177–182PubMedCrossRef

31.

Groll DL, To T, Bombardier C, Wright JG (2005) The development of a comorbidity index with physical function as the outcome. J Clin Epidemiol 58(6):595–602PubMedCrossRef

32.

Fillenbaum GG, Smyer MA (1981) The development, validity, and reliability of the OARS multidimensional functional assessment questionnaire. J Gerontol 36(4):428–434PubMedCrossRef

33.

Katz S (1983) Assessing self-maintenance: activities of daily living, mobility, and instrumental activities of daily living. J Am Geriatr Soc 31(0002–8614; 12):721–727PubMed

34.

Collaborative Staging Task Force of the American Joint Committee on Cancer (2004) Collaborative staging manual and coding instructions, version 01.04.00. Chicago, IL: Jointly published by the American Joint Committee on Cancer (Chicago, IL) and U.S. Department of Health and Human Services (Bethesda, MD); NIH Publication Number 04–5496

35.

Carbone PP, Kaplan HS, Musshoff K, Smithers DW, Tubiana M (1971) Report of the committee on Hodgkin’s disease staging classification. Cancer Res 31(11):1860–1861PubMed

36.

Durie BG, Salmon SE (1975) A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival. Cancer 36(3):842–854PubMedCrossRef

37.

Johansson BB, Holmberg L, Berglund IG, Sjoden PO, Glimelius BL (2004) Determinants of cancer patients’ utilization of hospital care within two years after diagnosis. Acta Oncol 43(6):536–544PubMedCrossRef

38.

Puts MT, Monette J, Girre V, Pepe C, Monette M, Assouline S, Panasci L, Basik M, Miller WH Jr, Batist G, Wolfson C, Bergman H (2011) Are frailty markers useful for predicting treatment toxicity and mortality in older newly diagnosed cancer patients? Results from a prospective pilot study. Crit Rev Oncol Hematol 78(2):138–149PubMedCrossRef

39.

Common terminology criteria for adverse events (CTCAE) version 3.0. 2006.

40.

(2009) Reducing injuries from medication-related falls by generating targeted computerized alerts for high risk patients within an electronic prescribing system. Montreal: Canadian Patient Safety Institute

41.

Puts MT, Monette J, Girre V, Costa-Lima B, Wolfson C, Batist G, Bergman H (2010) Potential medication problems in older newly diagnosed cancer patients in Canada during cancer treatment: a prospective pilot cohort study. Drugs Aging 27(7):559–572PubMedCrossRef

42.

Studenski S, Perera S, Wallace D, Chandler JM, Duncan PW, Rooney E, Fox M, Guralnik JM (2003) Physical performance measures in the clinical setting. J Am Geriatr Soc 51(0002–8614; 3):314–322PubMedCrossRef

43.

Sourial N, Bergman H, Karunananthan S, Wolfson C, Guralnik J, Payette H, Gutierrez-Robledo L, Deeg DJ, Fletcher JD, Puts MT, Zhu B, Beland F. Contribution of frailty markers in explaining differences among individuals in five samples of older persons. J Gerontol A Biol Sci Med Sci. 2012 Mar 28 (in press)

44.

Panel on Prevention of Falls in Older Persons, American Geriatrics Society and British Geriatrics Society. (Summary of the updated American geriatrics Society/British geriatrics society clinical practice guideline for prevention of falls in older persons) J Am Geriatr Soc 2011;59(1):148–57

45.

Overcash JA, Rivera HR, Van Schaick J (2010) An analysis of falls experienced by older adult patients diagnosed with cancer. Oncol Nurs Forum 37(5):573–580PubMedCrossRef

Titel: The fall rate of older community-dwelling cancer patients
verfasst von: Martine T. E. Puts
Johanne Monette
Veronique Girre
Christina Wolfson
Michèle Monette
Gerald Batist
Howard Bergman
Publikationsdatum: 01.03.2013
Verlag: Springer-Verlag
Erschienen in: Supportive Care in Cancer / Ausgabe 3/2013
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-012-1579-4

Springer Medizin

The fall rate of older community-dwelling cancer patients