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01.12.2010

The Generation R study: a candidate gene study and genome-wide association study (GWAS) on health-related quality of life (HRQOL) of mothers and young children

verfasst von: Hein Raat, Lenie van Rossem, Vincent W. V. Jaddoe, Jeanne M. Landgraf, David Feeny, Henriëtte A. Moll, Albert Hofman, Johan P. Mackenbach

Erschienen in: Quality of Life Research | Ausgabe 10/2010

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Abstract

Aim

The aim of this paper is to describe the Generation R study as a template that enables candidate gene study and genome-wide association study regarding health-related quality of life (HRQOL) of mothers and their young children.

Methods

Generation R is a population-based prospective cohort study from fetal life onwards in Rotterdam, The Netherlands. Children were born in 2002–2006. Blood from mothers and placenta cord blood were sampled. Mothers’ HRQOL was measured 5 times during pregnancy and after birth using SF-12 and EQ-5D. Children’s HRQOL was measured 5 times between age 1 and 5/6 years using Infant-Toddler Quality Of Life questionnaire (ITQOL), Health Status Classification System PreSchool (HSCS-PS) and Child Health Questionnaire Parent Form 28 items (CHQ-PF28), respectively.

Results

DNA is available for 8,055 mothers and 5,908 children. Genotyping of various candidate genes and a genome-wide association (GWA) scan (Illumina 610K) of child DNA were done. A template for gene-HRQOL analyses is provided. We start with candidate gene study on HRQOL of mothers and children. Gene–environment interaction and interaction with medical indicators of health status will be explored. Next, GWA study on HRQOL will be performed.

Conclusions

Gaining insight into the determinants of HRQOL is essential to assisting efforts in health policy and clinical application to improve well-being and health. In the future, it might be possible to complement HRQOL assessments by examinations of genetic markers. Strengths and weaknesses of the Generation R study are discussed.

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Titel: The Generation R study: a candidate gene study and genome-wide association study (GWAS) on health-related quality of life (HRQOL) of mothers and young children
verfasst von: Hein Raat
Lenie van Rossem
Vincent W. V. Jaddoe
Jeanne M. Landgraf
David Feeny
Henriëtte A. Moll
Albert Hofman
Johan P. Mackenbach
Publikationsdatum: 01.12.2010
Verlag: Springer Netherlands
Erschienen in: Quality of Life Research / Ausgabe 10/2010
Print ISSN: 0962-9343
Elektronische ISSN: 1573-2649
DOI: https://doi.org/10.1007/s11136-010-9773-7

Springer Medizin

Abstract

Aim

Methods

Results

Conclusions

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