Background
Methods
Study population
Patient-level data
Factors associated with discontinuation of employment
Discontinuation of employment
Per patient productivity costs due to discontinuation of employment
Nationwide productivity costs
Ethical approval
Results
Description of adult CFS/ME cohort in the National Outcomes Database
Factors associated with discontinuation of employment
Currently employed | Employment discontinued | P-value* | |
---|---|---|---|
Age (years) | n = 811 | n = 998 | |
18 - 21 | 59 (57.3%) | 44 (42.7%) | |
22 - 29 | 153 (49.8%) | 154 (50.2%) | |
30 - 39 | 265 (51.5%) | 250 (48.5%) | |
40 - 49 | 202 (42.9%) | 269 (57.1%) | |
50 - 59 | 119 (34.6%) | 225 (65.4%) | |
60+ | 13 (18.8%) | 56 (81.2%) | < 0.001 |
Sex | n = 811 | n = 998 | |
Female | 643 (46.4%) | 743 (53.6%) | |
Male | 168 (39.7%) | 255 (60.3%) | 0.02 |
Duration of illness (months) | n = 743 | n = 878 | |
Median (IQR) | 35 (15 - 84) | 48 (18 - 120) | < 0.001 |
Chalder Fatigue (0 - 33) | n = 752 | n = 911 | |
Median (IQR) | 25 (21 - 30) | 27 (23 - 31) | < 0.001 |
SF-36 physical function (scale 0 - 100) | n = 744 | n = 901 | |
Median (IQR) | 50 (35 - 65) | 30 (20 - 45) | < 0.001 |
HADS anxiety (scale 0 - 21) | n = 751 | n = 916 | |
Median (IQR) | 10 (7 - 13) | 11 (7 - 14) | 0.02 |
HADS depression (scale 0 - 21) | n = 753 | n = 919 | |
Median (IQR) | 9 (6 - 12) | 10 (7 - 13) | < 0.001 |
Visual Analogue Pain (scale 0 - 100) | n = 717 | n = 886 | |
Median (IQR) | 43 (18 - 65) | 55 (26 - 72) | < 0.001 |
Variable* | Partially-adjusted odds ratio** (95% CI) | P-value | Fully-adjusted odds ratio*** (95% CI) | P-value |
---|---|---|---|---|
10-year age group | 1.31 (1.19, 1.44) | < 0.001 | 1.16 (1.05, 1.29) | 0.005 |
Sex (female vs male) | 0.76 (0.59, 0.98) | 0.03 | 0.62 (0.46, 0.82) | 0.001 |
Duration of illness (years) | 1.03 (1.01, 1.05) | 0.003 | 1.01 (0.99, 1.03) | 0.36 |
Chalder Fatigue | 1.20 (1.12, 1.29) | < 0.001 | 1.02 (0.93, 1.11) | 0.68 |
SF-36 (physical function) | 0.70 (0.66, 0.74) | < 0.001 | 0.71 (0.67, 0.76) | < 0.001 |
HADS anxiety | 1.04 (1.00, 1.09) | 0.06 | 0.98 (0.92, 1.04) | 0.42 |
HADS depression | 1.18 (0.98, 1.25) | 0.06 | 1.05 (0.98, 1.14) | 0.16 |
Visual Analogue Pain | 1.12 (1.08, 1.17) | < 0.001 | 1.00 (0.96, 1.05) | 0.84 |
Discontinuation of employment
Productivity costs due to discontinuation of employment
Sex and age (years) | Na
| Discontinued employment (%)b
| Median duration of illness (months)b
| Mean annual income (£)c
| Total loss of productivity (£)d
| Loss per person (£)e
| Population in PCTs in studyf
| Proportion of population who access services (per 100,000 per year) | UK population (1000's) | Number of people who might access services per year (UK) | Productivity costs among people who might access services (UK) |
---|---|---|---|---|---|---|---|---|---|---|---|
Male | |||||||||||
18 - 21 | 26 | 40% | 21 | 11,546 | 109,271 | ||||||
22 - 29 | 72 | 48% | 30 | 23,460 | 1,054,011 | 11,870 | 655,664 | 3.74 | 5,135 | 192 | 2,277,502 |
30 - 39 | 128 | 53% | 72 | 35,172 | 7,444,534 | 58,160 | 554,200 | 5.77 | 4,069 | 235 | 13,663,983 |
40 - 49 | 127 | 56% | 60 | 39,390 | 7,283,684 | 57,352 | 535,400 | 5.93 | 4,523 | 268 | 15,383,619 |
50 - 59 | 116 | 65% | 48 | 36,590 | 5,738,483 | 49,470 | 414,100 | 7.00 | 3,690 | 258 | 12,782,017 |
60 - 64 | 32 | 59% | 31 | 26,505 | 672,223 | 21,007 | 190,800 | 4.19 | 1,818 | 76 | 1,601,287 |
Subtotals | 501 | 22,302,206 | 44,515 | 2,350,164 | 5.33 | 19,234 | 1,030 | 45,708,408 | |||
Female | |||||||||||
18 - 21 | 150 | 25% | 36 | 8,875 | 469,266 | ||||||
22 - 29 | 294 | 43% | 26 | 18,508 | 2,382,677 | 6,423 | 638,346 | 17.39 | 4,922 | 856 | 5,497,849 |
30 - 39 | 461 | 43% | 36 | 22,047 | 6,162,231 | 13,367 | 548,400 | 21.02 | 4,086 | 858 | 11,475,526 |
40 - 49 | 411 | 53% | 48 | 20,880 | 8,550,786 | 20,805 | 541,600 | 18.97 | 4,631 | 879 | 18,280,147 |
50 - 59 | 281 | 61% | 55 | 19,893 | 7,345,405 | 26,140 | 423,200 | 16.60 | 3,796 | 630 | 16,469,450 |
60 - 64 | 72 | 60% | 87 | 13,662 | 2,011,101 | 27,932 | 200,000 | 9.00 | 1,901 | 171 | 4,779,382 |
Subtotals | 1,669 | 26,921,466 | 16,130 | 2,351,546 | 17.74 | 19,335 | 3,394 | 56,502,353 | |||
Totals | 2,170 | 49,223,672 | 22,684 | 4,701,710 | 11.54 | 4,424 | 102,210,761 |