Background
Methods
Study Design
Statistical Analysis
Results
Incident VF Group (I) | Incident Non-VF Group (II) | No Incident Fracture Group (III) | |
---|---|---|---|
Number of patients | 47 | 149 | 1813 |
Age-mean (SD) | 72.5 (8.6) | 68.5 (9.6) | 65.3 (8.8) |
Weight-kg | 62.2 (12.3) | 64.9 (12.6) | 64.8 (12.8) |
Height – cm | 154.4 (6.7) | 156.9 (6.6) | 157.4 (8.3) |
Dietary Ca-g/d | 0.8 (0.4) | 0.6 (0.3) | 0.6 (0.3) |
Exercise-hours/week | 1.8 (2.6) | 2.8 (3.4) | 2.9 (3.5) |
Race-# (%) | |||
Caucasian | 10 (21.3) | 29 (19.5) | 473 (26.1) |
Otherb
| 1 (2.1) | 0 (0) | 26 (1.4) |
Unknown | 36 (76.6) | 120 (80.5) | 1314 (72.5) |
BMD-mean (SD) | |||
LS-g/cm2
| 0.876 (0.131) | 0.941 (0.169) | 0.954 (0.148) |
FN-g/cm2
| 0.687 (0.101) | 0.715 (0.120) | 0.734 (0.109) |
Prevalent fractures – # (%) | |||
VF | 24 (51.1) | 38 (25.5) | 326 (18.0) |
Non-VF | 33 (70.2) | 98 (66.8) | 828 (45.7) |
Multiple VF (>1) | 16 (34.0) | 17 (11.4) | 194 (10.7) |
Multiple Non-VF (>1) | 22 (46.8) | 59 (39.6) | 467 (25.8) |
Concomitant diseases-# (%) | |||
Heart attack | 7 (14.9) | 25 (16.8) | 262 (14.5) |
Stroke | 3 (6.4) | 3 (2.0) | 58 (3.2) |
Cancerc
| 5 (10.6) | 15 (10.0) | 162 (8.9) |
Diabetes | 2 (4.3) | 6 (4.0) | 58 (3.2) |
Epilepsy | 2 (4.3) | 2 (1.3) | 17 (0.9) |
Arthritis | 25 (53.2) | 78 (52.4) | 1037 (57.2) |
Thyroid diseased
| 13 (27.7) | 36 (24.2) | 345 (19.0) |
Medications-# (%) | |||
Bisphosphonatese
| 40 (85.1) | 109 (73.2) | 1252 (69.1) |
Estrogen | 16 (34.0) | 50 (33.6) | 767 (42.3) |
Other medicationsf
| 4 (8.5) | 3 (2.0) | 42 (2.3) |
Incident Fractures and HRQL
Vertebral Fractures
Mini-OQLQ | Vertebral Fracture Group (I) | Non-Vertebral Fracture Group (II) | No Fracture Group (III) | ||||||
---|---|---|---|---|---|---|---|---|---|
Domains | Baseline | Follow-up | n | Baseline | Follow-up | n | Baseline | Follow-up | n |
Total Score | 4.27 (1.83) | 3.54 (1.79) | 14 | 4.99 (1.37) | 4.64 (1.35) | 52 | 5.46 (1.43) | 5.49 (1.36) | 685 |
Symptoms | 3.98 (1.76) | 3.26 (1.65) | 44 | 4.82 (1.62) | 4.64 (1.51) | 136 | 5.08 (1.61) | 5.07 (1.62) | 1711 |
Physical Functioning | 3.99 (2.11) | 3.26 (1.90) | 34 | 5.14 (1.68) | 4.83 (1.72) | 102 | 5.26 (1.77) | 5.31 (1.75) | 1192 |
Emotional Functioning | 4.16 (2.13) | 3.72 (2.27) | 45 | 5.41 (1.69) | 4.54 (1.85) | 139 | 5.65 (1.55) | 5.67 (1.49) | 1711 |
Activities of Daily Living | 4.25 (2.12) | 3.18 (1.91) | 30 | 5.24 (1.80) | 4.89 (1.84) | 105 | 5.34 (1.81) | 5.40 (1.75) | 1260 |
Leisure | 5.10 (2.07) | 4.31 (2.20) | 26 | 5.42 (1.84) | 5.51 (1.78) | 75 | 6.01 (1.54) | 6.02 (1.51) | 1012 |
Mini-OQLQ | Vertebral Fracture Group (I) | Non-Vertebral Fracture Group (II) | ||||||
---|---|---|---|---|---|---|---|---|
Domains | Estimates Unadjusted CI | (n) | Adjusted Estimates CI | (n) | Unadjusted Estimates CI | (n) | Adjusted Estimates CI | (n) |
Total Score | -0.77 | (699) | -0.86 | (673) | -0.38 | (737) | -0.47 | (711) |
-1.22, -0.31 | -1.30, -0.43 | -0.62, -0.13 | -0.70, -0.25 | |||||
Symptoms | -0.70 | (1755) | -0.76 | (1214) | -0.17 | (1847) | -0.25 | (1295) |
-1.12, -0.29 | -1.23, -0.30 | -0.41, 0.07c
| -0.49, -0.01 | |||||
Physical Functioning | -0.76 | (1226) | -1.12 | (1113) | -0.35 | (1294) | -0.39 | (1181) |
-1.20, -0.32 | -1.57, -0.67 | -0.62, -0.09 | -0.65, -0.14 | |||||
Emotional Functioning | -0.46 | (1756) | -1.06 | (1581) | -0.90 | (1850) | -0.97 | (1669) |
-0.85, -0.07 | -1.44, -0.68 | -1.13, -0.66 | -1.20, -0.75 | |||||
Activities of Daily Living | -1.13 | (1290) | -1.47 | (1116) | -0.41 | (1365) | -0.47 | (1188) |
-1.63, -0.63 | -1.97, -0.96 | -0.69, -0.14 | -0.73, -0.21 | |||||
Leisure | -0.81 | (1038) | -0.92 | (991) | 0.08 | (1087) | -0.05 | (953) |
-1.29, -0.32 | -1.37, -0.47 | -0.22, 0.37c
| -0.32, 0.23c
|