The impact of orthodontic treatment on the quality of life a systematic review

Fixed orthodontic appliance therapy is a regular orthodontic treatment to correct variations from an arbitrary norm (align the teeth or correct other irregularities) [1], which may cause functional restrictions, discomfort and pain [2, 3], but traditional orthodontic studies have only included clinician-based outcome measures.

Since Cohen and Jago [4] advocated development of ‘social-dental’ indicators, there has been considerable subjective patient-based measurement results leading to further understanding about psychosocial well-being and/or dental health [5]. Hence, oral health–related quality of life (OHRQoL) is defined as ‘the absence of negative impacts of oral conditions on social life and a positive sense of dentofacial self-confidence’. Thus, studying the OHRQoL index may provide information that will help clinicians and public health planners improve the quality of orthodontic care [6]. With regard to fixed orthodontic appliance therapy, understanding the consequences and discomforts during orthodontic procedures affords patients more realistic expectations regarding orthodontic treatment and may increase adherence to treatment [7, 8].

Although many specific OHRQoL measures have been developed to analyse the impact of wearing a fixed appliance [9], there is still a paucity of systematic appraisal of the consequences of orthodontics on quality of life(QoL). QoL is important in providing an understanding of the importance of, and priority for, orthodontic care within the health care spectrum. Thus, the aim of this review was to assess the literature related to the impact of orthodontic treatment and orthodontic care on QoL, HRQoL and OHRQoL.

To be included in the review, trials had to meet the following selection criteria:

Participants: patients receiving orthodontic treatment and non-orthodontic treatment

Interventions: Fixed or removable appliance, or interceptive orthodontic treatment.

Outcome measures: Changes in oral health–related quality of life (OHRQoL) from baseline (pre-treatment) to follow-up at least 1 month.

Exclusion criteria were lack of standardized measures in assessing QoL, HRQoL or OHRQoL; lack of effective statistical analyses; and case reports and review papers.

A total of 204 potentially relevant articles were collected through initial literature and hand search, of which 183 were excluded based on their titles and abstracts. Full text articles of 21 studies were retrieved. Of these, 11 studies qualified for the review analysis. The flow of the inclusion process is shown in Figure 1.

Among the 11 included papers, six [11‐16] were cohort studies with a good follow up and were classified as level 1B evidence according to the Oxford Centre for evidence based Medicine criteria. Four studies were cross-sectional designed, three [17‐19] of which offered 3B evidence level because of the convenient samples; one [20] offered 2C evidence level due to the large community sample. The single remaining paper [21] was a case-control study with randomized sample type, which offered 3C evidence level.

Four QoL instruments, generic and oral health specific, were applied to the 11 included papers, namely OHIP, OIDP, CPQ and OHQoL-UK. OHIP (7 of 14) and CPQ (3 of 14) were the two most frequently used QoL instruments. OHIP was applied to both adults and Children, while CPQ was only used on children.

Given the fact that different methods were applied to measure QoL, and different time intervals employed in assessing QoL, meta-analysis was not feasible to combine these statistical results. However, a majority of studies indicated a correlation between orthodontic treatment and QoL no matter what measurement was applied. The cross-sectional studies revealed that orthodontic treatment resulted in a decrease in QoL scores. Whereas the longtitudinal studies indicated that with ongoing orthodontic treatment, the QoL score may increase a few weeks after initial orthodontic appliance placement. QoL might even be improved during the late stages of treatment (Table 2).

The present review was performed to systematically analyze the impact of orthodontic treatment on quality of life. The results suggest that there is an association between orthodontic treatment and QoL. Most studies reported that patients were considerably compromised in terms of their overall OHRQoL until approximately 1 month after appliance insertion. The severity of the compromised condition in terms of overall OHRQoL was greatest at 1 week with the reported impact on physical pain, psychological discomfort, and physical disability. Patients’ OHRQoL was better after they completed orthodontic treatment than it was before or during treatment. Only one study [17] reported worse OHRQoL compared with a control group with no malocclusion and not wearing a fixed appliance.

QoL is a somewhat intangible entity and there has been much debate as to how to define it. However, since there is general consensus that QoL reflects physical, social, and psychologic functioning, these terms formed the basis of the literature search methodology [22]. It is now generally accepted that the measurement of oral health-related quality of life is an essential component of oral health surveys, clinical trials, and studies evaluating the outcomes of preventive and therapeutic programs intended to improve oral health. The assessment of oral health-related quality of life has an important role in clinical practice. There were a number of studies measuring oral health-related quality of life. The literature search yielded more than 200 potentially relevant articles, demonstrating a paradigm shift from the biophysical focus of malocclusion to a more patient-centered focus of orthodontic treatment and management. Furthermore, it was apparent that QoL had been a particularly common topic of research in the past decade within all dental disciplines [23].

In this review, a recommended approach to the conduct, methodology and reporting of systematic reviews was followed [24]. Only studies which used previously validated measures of OHRQoL were included. Finally, there were 4 instruments measuring oral health-related quality of life in this study. The Child Perception Questionnaire (CPQ) and the Oral Health Impacts Profile (OHIP) measure were most frequently used in the assessment of OHRQoL. This shows that there is no shortage of standardized assessment methods for documenting changes in OHRQoL. However, the use of different assessment methods makes it difficult to conduct a meta-analysis.

Perhaps not too surprisingly, the majority of the research in this area has focused on the impact of orthodontic treatment on the QoL in children rather than adults. This relates in part to the fact that children make up the majority of orthodontic patients, although it is increasingly recognized that more and more adults are seeking correction of their malocclusion [25].

In this systematic review, we included both short (3/11) and long-term follow-up (6/11) studies so as to assess changes during and after orthodontic treatment. From the short-term results, Man [13] found that changes in OHRQoL occur after fixed orthodontic appliance therapy. Compared with pretreatment, a patient’s OHRQoL is frequently worse during treatment (oral symptoms, functional limitations), although it is better in some aspects (emotional well-being). The period of greatest change in OHRQoL occurs during the first month of treatment. Ling Aihua [19] and Eduardo [21] found similar results indicating that orthodontic treatment does affect patients' OHRQOL, the impact being more serious in the first month of treatment. The longitudinal data [7, 11, 14‐16, 18] on pre- and post-orthodontic treatment showed that both children and adult patients who received orthodontics had significantly better oral health-related quality of life scores in the retention phase, after treatment completion, compared to non-treated subjects. Zhijian [15] also found that the greatest deterioration in OHRQoL occurs in the early phase of treatment; the detrimental effects on OHRQoL are reduced with ongoing treatment. Daniela [14] found that fixed orthodontic treatment in Brazilian children resulted in significantly improved OHQoL after completing 2 years of orthodontic therapy.

The level or strength of evidence that can be gleaned from the included papers was relatively high. Most were longitudinal studies with good follow up, despite lacking randomized controlled trials (RCTs). Because of ethical issues, orthodontics frequently does not lend itself very well to randomized controlled trials, particularly when children are involved. Of note, studies generally observed an association between orthodontic treatment and HRQoL, irrespective of how the parameters were assessed. However, the inferences from the correlation statistics and regression findings would indicate that the strength of the association could be interpreted as moderate.

Certain limitations must be acknowledged. Most of the included studies were observational and therefore at a greater risk of bias and confounding which could compromise the internal and external validity of their results [26].

Many factors, such as age, gender and psychological and socio-economic factors might have confounded the outcomes of treatments and patients’ perceptions of QoL. Furthermore, different OHRQoL measures were used in the included studies, potentially leading to differences in the way OHRQoL was assessed, as certain measures are more likely to capture specific aspects (domains) of OHRQoL than others.

Attention also should be paid to the potential possibility of publication bias, not only are positive results more easily published, but it is also difficult to retrieve all the available literature. The results are vulnerable to the impact of publication bias, which may be minimized by obtaining printed copies of orthodontic journals, and prone to the limitations of accessing online data references, or conducting Google or other electronic searches.

Finally, a meta-analysis was not performed because of concerns that the clinical and methodological diversity (heterogeneity) of the included studies would make the process meaningless. Studies differed in (1) participants; (2) the outcome (OHRQoL) measures used and (3) durations of follow-up. Confounding factors and potential biases in the data might have further compromised a meta-analysis leading to a misinterpretation of results.

Therefore, future research should be improved as follows: First, by adopting a common OHRQoL-measure to ensure consistency of recording outcomes and enable meta-analysis of their relationship. Second, further well-designed prospective cohort studies with long-term follow-up are required to confirm and replicate the findings reported here. Future RCTs should evaluate OHRQoL-outcomes in patients receiving orthodontic treatment, while adjusting potential confounding factors. The impact of therapy on OHRQoL in patients with varying severities of malocclusion also requires investigation.

In literature there is a growing interest in the relationship between orthodontic treatment and HRQoL and it suggests that orthodontics can moderately improve the OHRQoL of patients. In future, however, there is still a need to determine appropriate assessment methods of orthodontic treatment and of quality of life (QoL, HRQoL, and/orOHRQoL measures) to enable meta-analysis of their relationship.

Search strategy for pubmed

#1 (“orthodontic”[Mesh]) OR (orthodontics)

#2 (orthodontic AND (therapy OR treatment))

#3 (quality of life OR oral health related quality of life OR QoL OR OHRQoL)

#4 (impact AND (orthodontic AND

(therapy OR treatment)))

#5 (#1 AND #2)

#6 (#5 OR #2)

#7 (#3 OR #4)

#8 (#6 AND #7)