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29.10.2018 | Dermatology and Wound Care (C Sayed and D Culton, Section Editors)

The Impact of Sunlight on Skin Aging

verfasst von: Hisham Kaddurah, Taylor L. Braunberger, Gautham Vellaichamy, Amanda F. Nahhas, Henry W. Lim, Iltefat H. Hamzavi

Erschienen in: Current Geriatrics Reports | Ausgabe 4/2018

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Abstract

Purpose of Review

In this review, we summarize and discuss the current literature on photoaging. We focus on the molecular effects of UV radiation, and the histological and clinical features of chronically sun-exposed skin.

Recent Findings

The expression of numerous proteins is altered in habitually sun-exposed skin, including sirtuins and hedgehog signaling proteins. Pharmacological manipulation of the levels of these proteins can potentially downregulate the photoaging process.

Summary

Mitochondrial and nuclear DNA damage, reactive oxygen species (ROS) production, and altered gene expression patterns are critical components of both photoaging and chronological aging. Chronic UVA and UVB exposure result in the photoaged phenotype through distinct molecular mechanisms, with UVA being primarily ROS-mediated and UVB being DNA damage-mediated. Molecular effects result in an altered dermal and epidermal environment that manifests as the photoaged phenotype. Importantly, skin phototype and environmental influences impact individual responses to chronic UV radiation.

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Titel: The Impact of Sunlight on Skin Aging
verfasst von: Hisham Kaddurah
Taylor L. Braunberger
Gautham Vellaichamy
Amanda F. Nahhas
Henry W. Lim
Iltefat H. Hamzavi
Publikationsdatum: 29.10.2018
Verlag: Springer US
Erschienen in: Current Geriatrics Reports / Ausgabe 4/2018
Elektronische ISSN: 2196-7865
DOI: https://doi.org/10.1007/s13670-018-0262-0

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The Impact of Sunlight on Skin Aging

Abstract

Purpose of Review

Recent Findings

Summary

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