Background
Methods
Patients
Data collection
Laboratory measurements
Related definitions
Medical formulas
Statistical analysis
Results
Characteristic | SCH (n = 46) | Euthyroid (n = 96) | P-value |
---|---|---|---|
Gender (male/female)b | 23/23 | 49/47 | 0.91 |
Duration of T2DM (years)a | 12.74 ± 10.40 | 11.63 ± 6.79 | 0.45 |
History of hypertension (have/none)b | 15/31 | 25/71 | 0.42 |
BMI (kg/m2) a | 25.14 ± 2.86 | 25.21 ± 2.98 | 0.89 |
TC (mmol/L)a | 2.08 ± 1.15 | 2.13 ± 2.69 | 0.90 |
TG (mmol/L)a | 4.20 ± 0.98 | 4.37 ± 1.56 | 0.51 |
HDL-C (mmol/L)a | 1.09 ± 0.30 | 1.17 ± 0.29 | 0.10 |
LDL-C (mmol/L)a | 2.18 ± 0.66 | 2.29 ± 0.72 | 0.38 |
Baseline creatinine (μmol/L)b | 77.80 ± 27.19 | 67.25 ± 17.66 | 0.01 |
Baseline eGFR (ml/min)b | 90.49 ± 35.04 | 103.03 ± 32.26 | 0.04 |
Baseline UACR (mg/mmol)b | 4.82 ± 8.38 | 3.68 ± 6.25 | 0.64 |
TSH (μIU/ml) b | 8.57 ± 6.31 | 2.09 ± 0.96 | 0.00 |
FT3 (mU/ml)b | 4.12 ± 0.88 | 4.42 ± 0.70 | 0.03 |
FT4 (mU/ml)b | 17.61 ± 14.66 | 16.71 ± 2.49 | 0.68 |
Group | Median | P25-P75 | P-value |
---|---|---|---|
SCH | 1.07 | (− 0.02,6.34) | < 0.001 |
Euthyroid | 0.00 | (− 0.68,0.60) |
stratified factors | Euthyroid M (Q) | SCH M(Q) | P-value& |
---|---|---|---|
Gender | |||
male | 0.10 (−0.40,1.20) | 1.20 (0.00,6.62) | < 0.01 |
female | -0.20 (− 0.74,0.30) | 0.80 (− 0.10,6.24) | < 0.01 |
BMI(kg/m2) | |||
normal | 0.25 (−0.49,1.75) | 1.140 (0.40,16.75) | < 0.01 |
overweight or obesity | −0.10(− 0.73,0.27) | 1.00 (− 0.09, 5.96) | < 0.01 |
Duration of T2DM (years) | |||
~ 10 | −0.10 (− 0.71,0.38) | 1.17 (− 0.03,12.13) | < 0.01 |
11~ | 0.04 (− 0.56,0.93) | 0.75 (− 0.02,6.34) | < 0.01 |
Control of glycemic | |||
well | 0.00 (−0.60,0.60) | 1.40 (0.18,5.68) | < 0.01 |
poor | 0.00 (−0.73,0.65) | 0.84 (−0.08,7.47) | < 0.01 |
History of hypertension | |||
have | −0.10 (− 0.75,1.23) | 0.90 (0.00,4.60) | < 0.01 |
none | 0.00 (−0.50,0.39) | 1.20 (−0.07,10.00) | < 0.01 |
β | SD | P-value | 95% CI | ||
---|---|---|---|---|---|
Group | −1.07 | 0.33 | 0.00 | −1.71 | − 0.43 |
BMI | −0.66 | 0.33 | 0.05 | −1.32 | −0.00 |
Control of glycemic | 0.19 | 0.331 | 0.561 | −0.46 | 0.85 |
Duration of T2DM | −0.25 | 0.30 | 0.42 | −0.85 | 0.35 |
Age | −0.05 | 0.19 | 0.78 | −0.44 | 0.33 |
Constant term | 2.80 | 1.14 | 0.02 | 0.54 | 5.07 |