Introduction
Methods
Results
NMDA-PC Prevents Ischemia-Induced p53 Stabilization in Pro72-p53 Neurons, but Not in Arg72-p53 Neurons
NMDA-PC Prevents Ischemia-Induced Apoptosis and Caspase-3 Activation in Pro72-p53 Neurons, but Not in Arg72-p53 Neurons
TIA Prevents Poor Prognosis After Stroke in Patients with the Pro72 allele, but Not in Those with the Arg/Arg Genotype
TIA (N = 25) | No TIA (N = 60) | |
---|---|---|
Age (years) | 71.20(±13.1) | 72.64(±13.1) |
Gender | ||
Males, n (%) | 14 (56) | 33 (55) |
Females, n (%) | 11 (44) | 27 (45) |
Previous | ||
Hypertension, n (%) | 16 (64) | 40 (66.6) |
Diabetes, n (%) | 8 (32) | 17 (28.3) |
Smoking, n (%) | 7 (28) | 8 (13.3) |
Hyperlipidemia, n (%) | 12 (48) | 23 (38.3) |
Atrial fibrillation, n (%) | 4 (16) | 14 (23.3) |
NIHSS on admission | ||
Minor stroke, n (%) | 12 (48) | 21 (35) |
Moderate stroke, n (%) | 11 (44) | 26 (43) |
Moderate to severe stroke, n (%) | 0 | 12 (20) |
Severe stroke, n (%) | 2 (8) | 1 (1.6) |
TOAST | ||
Cardioembolic, n (%) | 7 (28) | 17 (28) |
Atherothrombotic, n (%) | 5 (20) | 13 (21.6) |
Lacunar, n (%) | 2 (8) | 7 (11,6) |
Undetermined, n (%) | 4 (16) | 26 (43.3) |
Others, n (%) | 2 (8) | 2 (3.3) |
Tp53 Arg72Pro
| ||
Arg (Arg/Arg), n (%) | 12 (48) | 33 (55) |
Pro (Arg/Pro and Pro/Pro), n (%) | 13 (52) | 27 (45) |
Good prognosis | Poor prognosis |
p
| |
---|---|---|---|
Pro, n (%) | 13 (100%) | 0 | 0.04 |
Arg, n (%) | 8 (67%) | 4 (33%) |