Background
Methods
Patients
Follow up
Montreal cognitive assessment (MoCA)
Neuropsychological assessment battery (NAB)
Statistical analysis
Results
Baseline characteristics
Total | WFNS I-III | WFNS IV + V | p-value | |
---|---|---|---|---|
Number | 100% (104/104) | 56.7% (59/104) | 43.3% (45/104) | |
Age (years) | 56.4 +/− 13.7 | 57.8 +/− 15.2 | 54.5 +/− 11.3 | 0.22 |
Female sex | 43.3% (45/104) | 47.5% (28/59) | 37.8% (17/45) | 0.43 |
Male sex | 56.7% (59/104) | 52.5% (31/59) | 61.2% (28/45) | 0.43 |
Anterior circulation aneurysma | 90.7% (97/107) | 93.5% (58/62) | 86.7% (39/45) | 0.43 |
Posterior circulation aneurysma | 9.3% (10/107) | 6.5% (4/62) | 13.3% (6/45) | 0.43 |
Mean aneurysm size (mm) | 6.7 +/− 3.8 | 5.8 +/− 3.1 | 8.0 +/− 4.4 | 0.009 |
Treatment and ICU stay
Total | WFNS I-III | WFNS IV + V | p-value | |
---|---|---|---|---|
Clippinga | 42.9% (42/98) | 39.3% (24/61) | 48.6% (18/37) | 0.49 |
Coilinga | 57.1% (56/98) | 60.6% (37/61) | 51.4% (19/37) | 0.49 |
No Treatmentb | 8.4% (9/107) | 1.6% (1/62) | 17.8% (8/45) | 0.009 |
DCI | 56.7% (47/83) | 49.1% (26/53) | 70.0% (21/30) | 0.11 |
Intraarterial Nimodipine for DCI | 76.6% (36/47) | 73.1% (19/26) | 81.0% (17/21) | 0.73 |
Balloon Angioplasty for DCI | 4.3% (2/47) | 7.7% (2/26) | 0% (0/21) | 0.50 |
Decompressive Hemicraniectomy | 19.4% (19/98) | 11.5% (7/61) | 32.4% (12/37) | 0.02 |
Mean ICU stay (days) | 21.2 +/− 10.5 | 18.9 +/− 10.3 | 24.9 +/− 9.7 | < 0.001 |
In-hospital mortality | 19.2% (20/104) | 8.5% (5/59) | 33.3% (15/45) | 0.003 |
GCS at discharge (median) | 13.0 (3–15) | 15.0 (3–15) | 9.0 (3–15) | |
GOSE at discharge (median) | 3.0 (1–8) | 4.5 (1–8) | 2.0 (1–4) | |
mRS at discharge (median) | 5.0 (0–6) | 3.0 (0–6) | 5.0 (3–6) | |
GOSE ≥5 | 25.5% (24/94) | 47.1% (24/51) | 0% (0/43) | < 0.001 |
mRS ≤3 | 29.5% (28/95) | 50.0% (26/52) | 4.7% (2/43) | < 0.001 |
Clinical outcome at follow up
3 Months | 12 Months | 24 Months | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Total | WFNS I-III | WFNS IV + V | p-value | Total | WFNS I-III | WFNS IV + V | p-value | Total | WFNS I-III | WFNS IV + V | p-value | |
GOSE ≥5 | 56.5% (26/46) | 77.8% (21/27) | 26.3% (5/19) | 0.002 | 57.1% (20/35) | 73.7% (14/19) | 37.5% (6/16) | 0.07 | 74.1% (20/27) | 81.3% (13/16) | 63.6% (7/11) | 0.39 |
mRS ≤3 | 69.6% (32/46) | 85.2% (23/27) | 47.4% (9/19) | 0.016 | 68.6% (24/35) | 78.9% (15/19) | 56.3% (9/16) | 0.28 | 77.8% (21/27) | 87.5% (14/16) | 63.6% (7/11) | 0.19 |
NAB-S impossible | 35.1% (13/37) | 23.8% (5/21) | 50.0% (8/16) | 0.19 | 24.1% (7/29) | 15.4% (2/13) | 31.3% (5/16) | 0.41 | 11.1% (3/27) | 6.3% (1/16) | 18.2% (2/11) | 0.55 |
Impaired MoCA | 68.6% (24/35) | 60.0% (12/20) | 80.0% (12/15) | 0.28 | 66.7% (18/27) | 50.0% (6/12) | 80.0% (12/15) | 0.13 | 58.3% (14/24) | 64.3% (9/14) | 50.0% (5/10) | 0.68 |
Returned to work | 0% (0/42) | 0% (0/23) | 0% (0/19) | 1.0 | 23.5% (8/34) | 36.8% (7/19) | 6.7% (1/15) | 0.05 | 37.5% (9/24) | 53.8% (7/13) | 18.2% (2/11) | 0.11 |
Neuropsychological outcome
Return to work
Medium impairment of NAB-S domains | Severe impairment of NAB-S domains | MoCA | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
< 2 | ≥2 | p-value | < 1 | ≥1 | p-value | impaired | unimpaired | p-value | ||
Return to work | 12 months | 50.0% (7/14) | 0% (0/7) | 0.047 | 50.0% (7/14) | 0% (0/7) | 0.047 | 14.3% (1/7) | 57.1% (4/7) | 0.266 |
24 months | 57.1% (8/14) | 0% (0/5) | 0.045 | 57.1%(8/14) | 0% (0/5) | 0.045 | 22.2% (2/9) | 40.0% (2/5) | 0.580 |