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01.12.2008 | Original Paper

The Pathways Study: a prospective study of breast cancer survivorship within Kaiser Permanente Northern California

verfasst von: Marilyn L. Kwan, Christine B. Ambrosone, Marion M. Lee, Janice Barlow, Sarah E. Krathwohl, Isaac Joshua Ergas, Christine H. Ashley, Julie R. Bittner, Jeanne Darbinian, Keren Stronach, Bette J. Caan, Warren Davis, Susan E. Kutner, Charles P. Quesenberry, Carol P. Somkin, Barbara Sternfeld, John K. Wiencke, Shichun Zheng, Lawrence H. Kushi

Erschienen in: Cancer Causes & Control | Ausgabe 10/2008

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Abstract

Objective

With 2.3 million breast cancer survivors in the US today, identification of modifiable factors associated with breast cancer recurrence and survival is increasingly important. Only recently new studies have been designed to examine the impact of lifestyle factors on prognosis, including Pathways, a prospective study of women with breast cancer in Kaiser Permanente Northern California (KPNC).

Methods

Pathways aims to examine the effect on recurrence and survival of (1) lifestyle factors such as diet, physical activity, quality of life, and use of alternative therapies and (2) molecular factors such as genetic polymorphisms involved in metabolism of chemotherapeutic agents. Eligibility includes any woman diagnosed with invasive breast cancer within KPNC, no previous diagnosis of other invasive cancer, age 21 years or older, and ability to speak English, Spanish, Cantonese, or Mandarin. Newly diagnosed patients are identified daily from electronic pathology records and are enrolled within two months of diagnosis. An extensive baseline interview is conducted, blood and saliva samples are collected, and body measurements are taken. Women are followed for lifestyle updates, treatment, and outcomes by self-report and query of KPNC databases.

Results

Recruitment began in 9 January, 2006, and as of 16 January, 2008, 1,539 women have been enrolled along with collection of 1,323 blood samples (86%) and 1,398 saliva samples (91%).

Conclusions

The Pathways Study will become a rich resource to examine behavioral and molecular factors and breast cancer prognosis.

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Titel: The Pathways Study: a prospective study of breast cancer survivorship within Kaiser Permanente Northern California
verfasst von: Marilyn L. Kwan
Christine B. Ambrosone
Marion M. Lee
Janice Barlow
Sarah E. Krathwohl
Isaac Joshua Ergas
Christine H. Ashley
Julie R. Bittner
Jeanne Darbinian
Keren Stronach
Bette J. Caan
Warren Davis
Susan E. Kutner
Charles P. Quesenberry
Carol P. Somkin
Barbara Sternfeld
John K. Wiencke
Shichun Zheng
Lawrence H. Kushi
Publikationsdatum: 01.12.2008
Verlag: Springer Netherlands
Erschienen in: Cancer Causes & Control / Ausgabe 10/2008
Print ISSN: 0957-5243
Elektronische ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-008-9170-5

Springer Medizin

The Pathways Study: a prospective study of breast cancer survivorship within Kaiser Permanente Northern California