Background
Methods
Patient recruitment
Data collection
Statistical analyses
Ethical and legal aspects
Results
Demographic- and disease-related characteristics
Total (n = 380) | ||||
---|---|---|---|---|
All | Women (n = 127) 33% | Men (n = 253) 67% | p | |
Demographic factors | ||||
Age (years) | 45.8 (12.0) | 45.8 (12.4) | 45.4 (11.8) | 0.754 |
Married/cohabiting | 286 (75%) | 94 (74%) | 192 (76%) | 0.642 |
Employed | 263 (73%) | 81 (67%) | 185 (74%) | 0.088 |
Education | 0.736 | |||
≤ 10 years | 42 (12%) | 13 (10%) | 30 (12%) | |
11–13 years | 122 (32%) | 39 (31%) | 83 (33%) | |
> 13 years | 213 (56%) | 75 (59%) | 138 (55%) | |
Exercise <1 h per week | 54 (14%) | 16 (13%) | 38 (15%) | 0.523 |
Exercise 1–3 h per week | 132 (35%) | 47 (37%) | 85 (34%) | |
Exercise >3 h per week | 191 (51%) | 63 (50%) | 128 (51%) | |
Current smoker | 105 (28%) | 36 (28%) | 69 (28%) | 0.861 |
Alcohol consumption (per week) |
0.023
| |||
Never | 73 (19%) | 33 (26%) | 40 (16%) | |
1–6 glasses | 263 (70%) | 84 (67%) | 179 (71%) | |
7 glasses or more | 41 (11%) | 9 (7%) | 33 (13%) | |
BMI (kg/m2) | 26.9 (4.6) | 25.5 (4.7) | 27.5 (4.5) |
<0.001
|
Disease duration (years) | 13.8 (11.4) | 12.6 (11.2) | 14.4 (11.5) | 0.158 |
Disease marker | ||||
HLA-B27 positive | 331 (90%) | 107 (87%) | 224 (91%) | 0.182 |
Disease activity measures | ||||
CRP (mg/dl) | 8.58 (11.94) | 7.89 (13.25) | 8.2 (11.24) | 0.446 |
BASDAI (0–10) | 3.17 (2.11) | 3.46 (2.06) | 3.03 (2.12) | 0.059 |
MASES (0–13) | 3.19 (3.75) | 4.41 (3.85) | 2.57 (3.54) |
<0.001
|
Health status | ||||
Morning stiffness | 0.663 | |||
< 30 min | 230 (60%) | 76 (62%) | 148 (59%) | |
> 31 min | 151(40%) | 47 (38%) | 101 (41%) | |
BASFI (0–10) | 2.71 (2.23) | 2.77 (2.24) | 2.68 (2.22) | 0.740 |
BAS-G (0–10) | 3.88 (2.57) | 4.03 (2.51) | 3.81 (2.61) | 0.447 |
HAQ (0–3) | 0.56 (0.49) | 0.64 (0.53) | 0.52 (0.47) | 0.034 |
Damage score | ||||
BASMI (0–10) | 2.39 (2.41) | 2.03 (1.60) | 2.38 (2.19) |
0.013
|
Current treatment | ||||
NSAIDs | 167 (44%) | 59 (47%) | 108 (43%) | 0.485 |
Synthetic DMARDs | 19 (5%) | 8 (6%) | 11 (4%) | 0.410 |
Biological DMARDs | 88 (23%) | 23 (18%) | 65 (25%) | 0.098 |
Prednisolone | 17 (4%) | 7 (5%) | 10 (4%) | 0.535 |
Co-morbidity | ||||
Mean total score for co-morbidity (range 0–10) | 0.7 (0.9) | 0.7 (0.9) | 0.6 (0.9) | 0.542 |
HRQoL in patients with ax-SpA
All | Women
n = 127 | Men
n = 253 | p | |
---|---|---|---|---|
Health-related quality of life | ||||
SF-36a
| ||||
Mental health | 77.2 (14.6) | 77.1 (14.1) | 77.2 (14.8) | 0.952 |
Vitality | 47.9 (20.3) | 44.9 (29.9) | 49.2 (19.8) | 0.056 |
Bodily pain | 48.5 (20.4) | 45.2 (19.8) | 50.1 (20.5) |
0.025
|
General health | 53.8 (21.1) | 55.3 (21.3) | 53.0 (21.0) | 0.336 |
Social function | 75.8 (22.1) | 73.9 (22.5) | 75.8 (21.8) | 0.239 |
Physical function | 73.5 (20.2) | 72.4 (19.1) | 74.0 (20.8) | 0.455 |
Physical role limitations | 43.3 (41.3) | 36.5 (39.8) | 46.5 (41.7) |
0.024
|
Emotional role limitations | 72.3 (39.9) | 69.7 (42.1) | 73.6 (38.7) | 0.375 |
SF-36-PCS | 39.6 (9.5) | 38.7 (9.2) | 40.1 (9.6) | 0.169 |
SF-36-MCS | 48.3 (10.2) | 47.7 (10.3) | 48.5 (10.2) | 0.498 |
SF-6Db
| 0.66 (0.10) | 0.66 (0.10) | 0.67 (0.08) | 0.395 |
15Dc
| 0.85 (0.09) | 0.85 (0.08) | 0.85 (0.10) | 0.859 |
Adjusted associations between demographic- and disease-related variables and HRQoL
SF-36-PCS Range 0–100 | SF-36-MCS Range 0–100 | 15D Range 0–1 | SF-6D Range 0–1 | |||||
---|---|---|---|---|---|---|---|---|
Adj. B (95% CI) | p | Adj. B (95% CI) | p | Adj. B (95% CI) | p | Adj. B (95% CI) | p | |
Demographic factors | ||||||||
Age (years) | −0.01 (−0.08, 0.06) | 0.799 | 0.75 (−0.03, 0.18) | 0.161 | 0.000 (0.000, 0.001) | 0.267 | 0.000 (0.000, 0.001) | 0.306 |
Female | 0.19 (−1.54, 1.92) | 0.830 | 0.27 (−2.23, 2.77) | 0.834 | −0.011 (−0.027, 0.005) | 0.192 | 0.004 (−0.015, 0.023) | 0.693 |
Living alone | 0.40 (−1.45, 2.26) | 0.669 | −0.49 (−3.78, 2.19) | 0.718 | 0.002 (−0.016, 0.019) | 0.838 | −0.005 (−0.025, 0.016) | 0.644 |
Employment | −1.15 (−3.05, 0.74) | 0.233 | −2.46 (−5.20, −0.29) | 0.079 | −0.014 (−0.031, 0.004) | 0.135 | −0.015 (−0.036, 0.006) | 0.164 |
Education duration | ||||||||
≤ 10 years | −0.86 (−3.41, −1.69) | 0.506 | −0.71 (−4.41, −2.97) | 0.666 | −0.019 (−0.042, 0.005) | 0.119 | 0.018 (−0.010, 0.047) | 0.207 |
11–13 years | −0.01 (−1.68, 1.70) | 0.992 | 0.09 (−2.35, 2.54) | 0.701 | 0.007 (−0.009, 0.023) | 0.392 | −0.001 (−0.020, 0.017) | 0.893 |
> 13 years | Ref | Ref | Ref | Ref | ||||
Exercise >3 h per week | 2.71 (0.21, 4.99) |
0.020
| 2.58 (−0.72, 5.89) | 0.125 | 0.036 (0.015, 0.058) |
0.001
| 0.053 (0.028, 0.078) |
<0.001
|
Exercise 1–3 h per week | 2.73 (0.40, 5.06) |
0.022
| 1.84 (−1.54, 5.21) | 0.284 | 0.032 (0.010, 0.53) |
0.004
| 0.045 (0.019, 0.070) |
0.001
|
Exercise <1 h per week | Ref | Ref | Ref | Ref | ||||
Current smoker | −1.07 (−2.81, 0.67) | 0.227 | −1.40 (−1.12, 3.91) | 0.275 | 0.009 (−0.007. 0.025) | 0.284 | −0.002 (−0.021, 0.017) | 0.842 |
Alcohol (per week) | ||||||||
Never | −0.70 (−3.82, −2.23) | 0.607 | 2.74 (−1.62, 7.02) | 0.217 | 0.004 (−0.025, 0.032) | 0.798 | 0.010 (−0.023, 0.043) | 0.556 |
1–6 glasses | −0.85 (−3.49, −1.80) | 0.530 | 4.63 (0.80, 8.46) |
0.018
| 0.010 (−0.015, 0.034) | 0.428 | 0.019 (−0.010. 0.048) | 0.198 |
7 or more glasses | Ref. | Ref. | Ref. | Ref. | ||||
BMI (kg/m2) | 0.23 (−0.16, 0.20) | 0.799 | 0.03 (−0.23, −0.28) | 0.827 | −0.001 (−0.002, 0.001) | 0.447 | 0.001 (−0.002, 0.002) | 0.884 |
Disease activity | ||||||||
Measures | ||||||||
BASDAI (range 0–10) | −0.21 (−0.81, 0.57) | 0.729 | −0.38 (−1.37, 0.62) | 0.459 | −0.004 (−0.011, 0.002) | 0.201 | 0.002 (−0.006, 0.010) | 0.659 |
MASES (range 0–13) | −0.09 (−0.32, 0.13) | 0.421 | −0.02 (−0.35, 0.31) | 0.911 | −0.001 (−0.003, 0.001) | 0.251 | 0.001 (−0.003, 0.002) | 0.885 |
Health status | ||||||||
BASFI (range 0–10) | −1.05 (−1.86, −0.25) |
0.010
| 1.02 (−0.15, 2.18) | 0.086 | −0.004 (−0.011, 0.004) | 0.348 | 0.001 (−0.008, 0.010) | 0.866 |
BAS-G (range 0–10) | −0.91 (−1.45, −0.37) |
0.001
| −1.73 (−2.51, −0.95) |
<0.001
| −0.010 (−0.015, −0.005) |
<0.001
| −0.020 (−0.026, −0.014) |
<0.001
|
HAQ (range 0–3) | −4.61 (−7.30, −1.91) |
0.001
| −2.00 (−5.91, 1.90) | 0.313 | −0.051 (−0.076, −0.026) |
<0.001
| −0.054 (−0.084, −0.024) |
0.001
|
Damage score | ||||||||
BASMI (range 0–10) | −0.11 (−0.56, 0.34) | 0.629 | 0.05 (−0.60, 0.69) | 0.883 | 0.001 (−0.003, 0.005) | 0.730 | −0.002 (−0.007, 0.003) | 0.488 |
Co-morbidity | ||||||||
Mean total score for co-morbidity (range 0–10) | −0.19 (−1.20, 0.82) | 0.715 | −0.64 (−2.10, 0.82) | 0.388 | −0.014 (−0.023, −0.005) |
0.004
| −0.002 (−0.014,0.009) | 0.661 |
Centre | ||||||||
SSHF (N/Y) | −1.58 (−3.34, 0.18) | 0.079 | 1.47 (−1.08, 4.02) | 0.256 | −0.005 (−0.021, −0.012) | 0.582 | −0.013 (−0.032, 0.007) | 0.199 |
R2
| 57.1% | 21.5% | 60.2% | 56.9% |