Background
Methods
Study subjects
Biochemical analysis
Peripheral blood mononuclear cells preparation
Detection of MPO expression in PBMCs by western blot
Statistical analyses
Results
Baseline characteristics of the patients
Group A | Group B | Group C | |
---|---|---|---|
N = 33 | N = 23 | N = 29 | |
Age (year) | 63 ± 10 | 68 ± 9 | 67 ± 10 |
Male/female(n) | 18/15 | 12/11 | 20/9 |
BMI(kg/m2) | 23.6 ± 0.4 | 23.5 ± 0.52 | 23.6 ± 0.3 |
Smoking, n (%) | 20(61) | 13(56) | 19(69) |
SBP(mmHg) | 130 ± 4 | 127 ± 3 | 128 ± 3 |
DBP(mmHg) | 76 ± 2 | 74 ± 2 | 75 ± 2 |
Leukocyte ( 109/L) | 5.5 ± 1.95 | 6.7 ± 1.87* | 7.18 ± 2.10* |
Creatinine (μmol/L) | 109.7 ± 9.6 | 99.38 ± 4.5 | 99.65 ± 5.88 |
TG(mmol/L) | 2.05 ± 0.25 | 1.85 ± 0.22 | 2.8 ± 0.90 |
TC(mmol/L) | 5.05 ± 0.18 | 4.54 ± 0.18 | 4.8 ± 0.12 |
LVEF (%) | 0.59 ± .03 | 0.58 ± 0.02 | 0.57 ± 0.03 |
Gensini score | 29.7(21.0–56.2) | 35.1(23.8–55.0)* | 43.6(22.0–56.0)*, ** |
Medications, n (%) | |||
Aspirin | 13 (39) | 10 (43) | 11 (37) |
β-blocker | 15 (45) | 11 (47) | 14 (48) |
ACEI/ARB | 21 (67) | 16 (76) | 20 (68) |
CCB | 7 (22) | 4 (19) | 5 (17) |
Nitrate | 21 (63) | 16 (69) | 18 (62) |
Statin | 10 (30) | 8 (34) | 11 (37) |
Correlation analysis FPG with other parameters
Variables | r | p |
---|---|---|
MPO | 0.492 | 0.000 |
Gensini score | 0.568 | 0.000 |
Leukocyte count | 0.353 | 0.001 |
Neutrophil count | 0.220 | 0.048 |
hs-CRP | 0.453 | 0.001 |
TG | −0.37 | 0.734 |
TC | 0.014 | 0.900 |
Creatinine | 0.021 | 0.852 |
LVEF | −0.228 | 0.146 |
SBP | −0.095 | 0.397 |
DBP | −0.07 | 0.950 |
Age | −0.158 | 0.160 |
Gender | −0.068 | 0.546 |
Independent variablea | Partial regression coefficient | Standard error | Standardized regression coefficient | T | P |
---|---|---|---|---|---|
Constant | 2.339 | 0.615 | 3.802 | 0.000 | |
Hs-CRP | 0.014 | 0.004 | 0.306 | 3.588 | 0.001 |
MPO | 0.024 | 0.005 | 0.346 | 4.439 | 0.000 |
Gensini score | 0.051 | 0.015 | 0.279 | 3.359 | 0.001 |