The reproducibility of clinical OSA subtypes: a population-based longitudinal study
- 05.01.2022
- Sleep Breathing Physiology and Disorders • Original Article
Erschienen in:
- Verfasst von
- Priscila Farias Tempaku
- Luciana Oliveira e Silva
- Thaís Moura Guimarães
- Tatiana de Aguiar Vidigal
- Vânia D’Almeida
- Monica Levy Andersen
- Lia Bittencourt
- Sergio Tufik
- Erschienen in
- Sleep and Breathing | Ausgabe 3/2022
Abstract
Purpose
The identification of subgroups of obstructive sleep apnea (OSA) is critical to understand disease outcome and treatment response and ultimately develop optimal care strategies customized for each subgroup. In this sense, we aimed to perform a cluster analysis to identify subgroups of individuals with OSA based on clinical parameters in the Epidemiological Sleep Study of São Paulo city (EPISONO). We aimed to analyze whether or not subgroups remain after 8 years, since there is not any evidence showing if these subtypes of clinical presentation of OSA in the same population can change overtime.
Methods
We used data derived from EPISONO cohort, which was followed over 8 years after baseline evaluation. All individuals underwent polysomnography, answered questionnaires, and had their blood collected for biochemical examinations. OSA was defined according to AHI ≥ 15 events/h. Cluster analysis was performed using latent class analysis (LCA).
Results
Of the 1042 individuals in the EPISONO cohort, 68% agreed to participate in the follow-up study (n = 712), and 704 were included in the analysis. We were able to replicate the OSA 3-cluster solution observed in previous studies: disturbed sleep, minimally symptomatic and excessively sleepy in both baseline (36%, 45% and 19%, respectively) and follow-up studies (42%, 43%, and 15%, respectively). The optimal cluster solution for our sample based on Bayesian information criterion (BIC) was 2 cluster for baseline (disturbed sleep and excessively sleepy) and 3 clusters for follow-up (disturbed sleep, minimally symptomatic, and excessively sleepy). A total of 45% of the participants migrated clusters between the two evaluations (and the factor associated with this was a greater delta-AHI (B = − 0.033, df = 1, p = 0.003).
Conclusions
The results replicate and confirm previously identified clinical clusters in OSA which remain in the longitudinal analysis, with some percentage of migration between clusters.
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- Titel
- The reproducibility of clinical OSA subtypes: a population-based longitudinal study
- Verfasst von
-
Priscila Farias Tempaku
Luciana Oliveira e Silva
Thaís Moura Guimarães
Tatiana de Aguiar Vidigal
Vânia D’Almeida
Monica Levy Andersen
Lia Bittencourt
Sergio Tufik
- Publikationsdatum
- 05.01.2022
- Verlag
- Springer International Publishing
- Erschienen in
-
Sleep and Breathing / Ausgabe 3/2022
Print ISSN: 1520-9512
Elektronische ISSN: 1522-1709 - DOI
- https://doi.org/10.1007/s11325-021-02470-5
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