01.03.2021 | Vascular Biology (H. Pownall, Section Editor)
The Role of Phospholipid Transfer Protein in the Development of Atherosclerosis
verfasst von:
Xian-Cheng Jiang, Yang Yu
Erschienen in:
Current Atherosclerosis Reports
|
Ausgabe 3/2021
Einloggen, um Zugang zu erhalten
Abstract
Purpose of Review
Phospholipid transfer protein (PLTP), a member of lipid transfer protein family, is an important protein involved in lipid metabolism in the circulation. This article reviews recent PLTP research progresses, involving lipoprotein metabolism and atherogenesis.
Recent Findings
PLTP activity influences atherogenic and anti-atherogenic lipoprotein levels. Human serum PLTP activity is a risk factor for human cardiovascular disease and is an independent predictor of all-cause mortality. PLTP deficiency reduces VLDL and LDL levels and attenuates atherosclerosis in mouse models, while PLTP overexpression exerts an opposite effect. Both PLTP deficiency and overexpression result in reduction of HDL which has different size, inflammatory index, and lipid composition. Moreover, although both PLTP deficiency and overexpression reduce cholesterol efflux capacity, but this effect has no impact in macrophage reverse cholesterol transport in mice. Furthermore, PLTP activity is related with metabolic syndrome, thrombosis, and inflammation.
Summary
PLTP could be target for the treatment of dyslipidemia and atherosclerosis, although some potential off-target effects should be noted.