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Tumor Biology

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24.11.2015 | Review

The role of TWIST1 in epithelial-mesenchymal transition and cancers

verfasst von: Qing-Qing Zhu, Chenhui Ma, Qian Wang, Yong Song, Tangfeng Lv

Erschienen in: Tumor Biology | Ausgabe 1/2016

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Abstract

TWIST1 is a basic helix-loop-helix (bHLH) transcription factor which plays essential and pivotal roles in multiple stages of embryonic development, and significantly contributes to tumor metastasis, even tumor initiation and primary tumor growth. It is well recognized that TWIST1 is overexpressed in a variety of tumors. Overexpression of TWIST1 induces epithelial-mesenchymal transition (EMT), a key process in the metastases formation of cancer. TWIST1 also promotes the formation of cancer stem cells and facilitates the process of tumorigenesis. Numerous studies have shown that targeting TWIST1 or TWIST1-related molecules significantly inhibits tumor growth, restricts tumor metastasis, reverses drug resistance, and thus improves the survival of cancer patients. Therefore, it is important to provide a better understanding of the context-dependent regulation of TWIST1 in each individual epithelial tumor, which might reveal new therapeutic targets in cancer treatment.

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Titel: The role of TWIST1 in epithelial-mesenchymal transition and cancers
verfasst von: Qing-Qing Zhu
Chenhui Ma
Qian Wang
Yong Song
Tangfeng Lv
Publikationsdatum: 24.11.2015
Verlag: Springer Netherlands
Erschienen in: Tumor Biology / Ausgabe 1/2016
Print ISSN: 1010-4283
Elektronische ISSN: 1423-0380
DOI: https://doi.org/10.1007/s13277-015-4450-7

Springer Medizin

The role of TWIST1 in epithelial-mesenchymal transition and cancers

Abstract

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