The use of the buccal fat pad flap for oral reconstruction

After lidocaine (1%) with 1:100,000 epinephrine is infiltrated, Stensen’s duct should be identified with a lacrimal probe before incision to avoid damaging it during the procedure. A 2–3-cm mucosal incision was made at least 2 cm below the Stensen’s duct. Two or three tagging sutures were placed at the margin of the mucoperiosteal flap to gain appropriate surgical fields. The buccinator and zygomaticus major muscles were cut, and blunt dissection was carefully performed to create sufficient openings for herniating the fat pad without injuring the capsule overlying the fat pad. After the superficial fascia of the face was cut, the fat pad herniated spontaneously (Fig. 2). The capsules overlying the fat pad should not be torn so as to maintain its volume, and the arterioles and venules overlying the fat pad should be preserved to maintain the rich blood supply. Tissue forceps were used for the traction of the fat pad with minimal force to avoid tearing the capsule. Pedicled buccal fat pad was sutured and positioned using absorbable suture materials with minimal tension. Making the incision at the bone is a good technique for maintaining the position of the fat pad.

Cleft palate is a common congenital deformity [24, 25]. It is caused by incomplete fusion of the maxillary process during the developmental stage. Although many etiologic factors such as genetics and the environment have been suggested, the pathogenesis of cleft palate remains controversial [3, 4]. For the treatment of cleft palate, sealing the communication between the oral cavity and the nasal cavity is essential for successful treatment [25, 26]. Many types of flap design have been introduced for the treatment of cleft palate.

The success rate of cleft palate surgery is influenced by many factors. The main flap for the cleft palate surgery is fed by the greater palatine artery and the lesser palatine artery [24]. If the palatal defect is wide, the flap width will be narrowed. These long narrow flaps may cause problems with blood circulation, and wide expanses of exposed raw bone surface can cause extensive wound contracture after the operation [24‐26]. Ischemic damage and wound contracture is the main cause of postoperative palatal fistula. The incidence of postoperative palatal fistula is reported to be 4.6–12.5% and is dependent on the degree of the tissue defect [27]. Wound contracture after operation can cause shortening of the soft palate and may result in velopharyngeal insufficiency [28].

The BFP has abundant vascular supply. The operation field for the flap generation is also adjacent to the operation field of cleft palate surgery (Fig. 4). Most cleft palate patients are children, and the BFP is particularly well developed in children. BFP can be placed on the junction between the hard palate and soft palate to prevent possible palatal fistula (Fig. 4a) [24, 25], or it can be used for covering the raw bone surface after sealing the palatal flap (Fig. 4b) [26]. BFP is particularly useful for the repair of secondary defect after cleft palate surgery [3, 4].

Few publications, other than case or technical reports, have discussed BFP’s usefulness for cleft palate surgery. Studies with less than five patients were excluded, and six papers encompassing a total of 101 patients were included (Table 2). Two of the included papers had some common data [3, 4]; therefore, the actual number of patients may be overestimated. Only a single case of postoperative fistula was reported, and it was spontaneously healed without further treatment [3]. A maximum of a 20 × 10-mm palatal defect could be covered with BFP [3, 4]. Tongue flap or temporal fascia flap has been used to repair secondary palatal defects. However, both techniques require extensive operation time and have moderate donor site morbidity. Considering the ease of this technique and availability of BFP, it can be considered for the secondary repair of palatal fistula located at the posterior palate [3, 4]. However, with the current BFP technique, it is difficult to cover defects located at the anterior palate [4].

BFP may be used for the prevention of palatal fistula during palatoplasty [29]. It has been claimed that there is no impairment in function and growth of the palate covered with BFP compared to the use of conventional techniques [29]. However, there has been no comparative study in the function and growth of the palate after pedicled buccal fat pad application. Comparative analysis with conventional technique should be performed to validate the BFP as a preventive measure for cleft palate surgery.

Osteonecrosis can result from radiation therapy during the treatment of malignancy [30] or medications, such as bisphosphonate and denosumab [9]. The main mechanism of osteonecrosis is vascular impairment and resultant hypoxia. Additional microbial invasion and dental procedures are subsequent events that lead to the progression of osteonecrosis [31]. Nonsurgical therapy for osteonecrosis consists of regular dressing and prescription of supplemental antibiotics. Because of the avascular nature of the disease, hyperbaric oxygen therapy has also been used in some studies [32]. Surgical intervention involves the complete removal of necrotic bone and subsequent reconstruction with rich vascularized tissue [30]. Microvascular reconstruction has been used for the reconstruction of osteonecrosis because of poorly vascularized tissue beds in recipient sites [33].

After excluding the papers with a small sample size (≤5), only three papers discussing osteonecrosis of the jaw bone were included in this review (Table 3). The total number of patients was 43, and 38 patients showed uneventful healing (88.4%). Two cases of 100% uneventful healing were reported, in which patients showed bone exposure during follow-up after restarting medication [9]. Unsuccessful epithelial healing on the bone is frequently observed in cases with incomplete resection of the necrotic bone [30, 34]. These cases could be treated by additional resection of sequestrum [30, 34].

Some cases of osteonecrosis are poorly responsive to conservative therapy [30, 34]. For example, the success rate of conservative therapy for osteoradionecrosis has been reported to be 37–44% [35, 36]. Patients who cannot be treated by conservative therapy should receive surgical intervention. The location and size of the osteonecrosis are sometimes an obstacle for reconstruction with BFP [30]. Lower reconstructive success rates have been found with advanced stages of osteoradionecrosis compared to early stages [30]. A microvascular free flap can be used for advanced stages of osteoradionecrosis [33].

BFP has been frequently used in the successful reconstruction of intraoral defects, including those induced by benign tumors and cysts (Fig. 5). The first clinical application of BFP was for the closure of a defect in the palate induced by a tumor [13]. In Egyedi’s report [13], a split-thickness skin graft was applied on the BFP. Later, Tideman et al. [37] reported that epithelialization could be observed on the BFP without skin graft. The regenerated epithelium is parakeratinized stratified squamous epithelium and looks similar to the adjacent oral epithelium [38]. In cases of moderate-sized palatal defects, BFP allows early epithelialization without postoperative discomfort [39].

Twelve papers were included in this review after excluding the papers with a small sample size (≤5) (Table 4). The total number of patients was 202, and 180 patients showed uneventful healing (89.1%). Eighty-six defects were induced by malignant tumor, and 102 were induced by benign tumors. The anatomic location of the defect was mainly the maxilla (n = 141). Posterior mandible or buccal mucosal defects can also be restored by BFP, but a tumor-free resection margin is essential for successful treatment [40].

If there is a sound oral epithelium, BFP can be used for the coverage of autogenous free block bone graft [41, 42] or titanium mesh with particulate bone [8] on the opposite side of the sinus. As the maxillary sinus mucosa is thin and frequently removed during tumor surgery, well-vascularized BFP can be substituted for sinus mucosa to cover a bone graft [42]. When the BFP is used as a barrier for free bone graft, the incidence of infection and graft resorption may be reduced [41].

When using BFP to treat defects induced by a malignant tumor, postoperative radiation therapy should be considered. Any supplementary cancer therapy can induce bone exposure and fistula [38, 40]. As BFP can be used for the repair of bone necrosis defect, it should be spared for future use in malignant tumor patients [30]. For the reconstruction of tumor defects, excessive fat is required at times, and the patient may show limitation of mouth opening [43]. As the function of the buccal fat pad is lubrication during contracture of multiple muscles [44], loss of buccal fat can induce scar contracture and adhesion of muscles [43]. Therefore, active mouth-opening exercise is advised for these patients [43]. Excessive graft taking may also induce cheek depression [40].

Although there have been many successful applications of BFP for the reconstruction of tumors, the method also has limitations. Defect sizes exceeding 4 cm × 4 cm × 3 cm have higher failure rates [45]. Other authors have also advised that it should not be used for defects larger than 6 cm × 4 cm [8]. In a previous review, the complication rate was 16.4% among 165 cases of BFP graft [45]. The most frequent complication was breakdown followed by postoperative fistula formation [45].

Oral submucous fibrosis is a precancerous lesion in the oral mucosa. Mouth opening limitation due to fibrous contracture is a major clinical feature. Abnormal sensation of oral mucosa is also an accompanying symptom of oral submucous fibrosis [46]. As chewing areca nut is reported to be a potential etiology, oral submucous fibrosis is prevalent in India [46‐49] and Taiwan [50]. Complete cure for oral submucous fibrosis has barely been achieved [50]. Accordingly, functional restoration has been the main goal of the treatment.

There have been several reports about the application of BFP for the treatment of oral submucous fibrosis. Five papers were included in this review after excluding the papers with small sample sizes (≤5) (Table 5). Although the results have been described as favorable, evaluation criteria are unclear in most papers. The most important evaluation criteria for the treatment of oral submucous fibrosis should be long-term stability of mouth function. When BFP graft was compared to other surgical protocols, such as tongue flap, nasolabial flap, and free skin graft, there was no difference in mouth-opening ability during follow-up [46]. The exact demographic data such as patient’s age, potential etiology, the size of the lesion, and postoperative follow-up should be provided in future reports. As limitation of mouth opening has been reported as a complication of BFP [43], detailed surgical protocol about the graft amount should also be suggested. The overall evidence of BFP application in oral submucous fibrosis seems insufficient.

BFP has also been used as an interpositioning material for temporomandibular joint reconstruction. Free fat graft from the abdomen is used for the reconstruction of the temporomandibular joint, which results in functional improvement [51]. In contrast to the abdominal fat, BFP can be used as a pedicled flap because of its anatomical proximity [52]. When BFP is used for gap arthroplasty of the temporomandibular joint, minimal gap (6–7 mm) is advised [53]. The shrinkage rate is reported to be 28% [53]. If the prepared gap is large, a greater amount of fat is required, and vertical height of the mandibular ramus cannot be maintained [54]. Compared to temporal fascia graft, BFP is resilient and does not have muscle [55]. BFP is stable after grafting into the temporomandibular joint and can be detected on MRI 1 year after the operation [56].

In patients receiving maxillary advancement surgery by LeFort I osteotomy, the upper lip usually loses its normal concavity [57]. To improve the upper lip profile, BFP can be used as an augmentation material [57]. Skull base defect after tumor surgery also can be repaired by BFP [58]. After parotid gland resection, BFP can be used for the prevention of Frey syndrome [59]. BFP is also used for repairing perforated maxillary sinus membrane during dental implant surgery [60].