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Journal of Neurology

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01.10.2010 | Original Communication

Theta burst stimulation over the primary motor cortex does not induce cortical plasticity in Parkinson’s disease

verfasst von: Carsten Eggers, Gereon R. Fink, Dennis A. Nowak

Erschienen in: Journal of Neurology | Ausgabe 10/2010

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Abstract

The purpose of this study was to investigate whether a period of continuous theta burst stimulation (cTBS) induces cortical plasticity and thus improves bradykinesia of the upper limb in Parkinson’s disease. In eight patients with Parkinson’s disease (two females; mean age: 68.5 ± 5 years; disease duration: 4 ± 3 years) electrophysiological (motor evoked potentials, contralateral and ipsilateral silent period) and behavioural (Purdue pegboard test, UPDRS motor subscore) parameters were evaluated before (baseline condition) and after a 40-s period of (1) real or (2) sham continuous theta burst stimulation over the primary motor cortex contralateral to the more affected body side off dopaminergic drugs. Compared to baseline, cTBS did change neither measures of cortical excitability nor behavioural measures. cTBS over the primary motor cortex does not impact on cortical excitability or motor function of the upper limb in Parkinson’s disease. We interpret these data to reflect impaired cortical plasticity in Parkinson’s disease. This study is an important contribution to the knowledge about impaired plasticity in Parkinson’s disease.

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Titel: Theta burst stimulation over the primary motor cortex does not induce cortical plasticity in Parkinson’s disease
verfasst von: Carsten Eggers
Gereon R. Fink
Dennis A. Nowak
Publikationsdatum: 01.10.2010
Verlag: Springer-Verlag
Erschienen in: Journal of Neurology / Ausgabe 10/2010
Print ISSN: 0340-5354
Elektronische ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-010-5597-1

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Theta burst stimulation over the primary motor cortex does not induce cortical plasticity in Parkinson’s disease

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