Erschienen in:
22.02.2016 | Research Letter
Thyroid hormone levels in the cerebrospinal fluid correlate with disease severity in euthyroid patients with Alzheimer’s disease
verfasst von:
Alice Accorroni, Filippo Sean Giorgi, Riccardo Donzelli, Leonardo Lorenzini, Concetta Prontera, Alessandro Saba, Andrea Vergallo, Gloria Tognoni, Gabriele Siciliano, Filippo Baldacci, Ubaldo Bonuccelli, Aldo Clerico, Riccardo Zucchi
Erschienen in:
Endocrine
|
Ausgabe 3/2017
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Excerpt
Several reports suggest that subclinical abnormalities in thyroid function may play a role in Alzheimer’s disease (AD) [
1‐
3]. Because of the complexity of thyroid hormone (TH) transport and metabolism in the brain, this hypothesis should be tested by assaying TH in cerebrospinal fluid (CSF). Reduced T
3 and increased 3,3′,5′-triiodothyronine (rT
3) [
4], or decreased T
4 with unchanged T
3 [
5], were reported in CSF of AD patients. A limitation of these studies is the use of immunological methods, which were only validated for plasmatic TH. In the present investigation, we used mass spectrometry (MS) coupled to high-performance liquid chromatography (HPLC), a highly specific and sensitive analytical technique [
6], to assay CSF T
4, T
3 and rT
3 in a retrospective series of 35 patients (9 males, 26 females, age 66 ± 2 years), observed at the Neurological Unit of Pisa University. CSF TH concentrations were related to serum TH concentration, and to other laboratory and clinical variables. …