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Acta Neurologica Belgica

Erschienen in:

12.08.2020 | Review article

Tiagabine-related status epilepticus: a case report and systematic literature review

verfasst von: Geoffroy Hariri, Alexis Ferre, Stephane Legriel

Erschienen in: Acta Neurologica Belgica | Ausgabe 6/2020

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Abstract

Tiagabine-related status epilepticus (SE) is an uncommon complication of tiagabine use. We aimed to detail the features and outcomes in a patient with tiagabine poisoning and review the relevant literature. We describe a case of tiagabine-related SE and literature review based on a 1995–2019 PubMed search. We report the case of a 30-year-old man with super-refractory SE after tiagabine poisoning. He fully recovered after 72 h of general anesthesia and was discharged from the ICU on day 16. A literature review showed distinct features among patients with tiagabine-related SE. Tiagabine side effects were characterized by non-convulsive SE after a slight increase in tiagabine dose and a rapid favorable evolution after benzodiazepine and early tiagabine withdrawal. Generalized convulsive SE was a complication of voluntary or involuntary tiagabine poisoning and was particularly refractory. Both presentations are characterized by a return to baseline after prompt and adequate management. Tiagabine-related SE electroclinical features vary according to the underlying pathophysiological mechanism and can be life threatening. Recovery is the rule after tiagabine withdrawal and SE management with progressive therapeutic escalation guided by response to prior anticonvulsant treatments.

https://www.R-project.org. Accessed September 16, 2019.

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Titel: Tiagabine-related status epilepticus: a case report and systematic literature review
verfasst von: Geoffroy Hariri
Alexis Ferre
Stephane Legriel
Publikationsdatum: 12.08.2020
Verlag: Springer International Publishing
Erschienen in: Acta Neurologica Belgica / Ausgabe 6/2020
Print ISSN: 0300-9009
Elektronische ISSN: 2240-2993
DOI: https://doi.org/10.1007/s13760-020-01464-6

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