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7733 Suchergebnisse für:

Acetylsalicylic Acid 

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  1. 03.04.2024 | Online First

    Physiological healing of chronic gastric ulcer is not impaired by the hydrogen sulphide (H2S)-releasing derivative of acetylsalicylic acid (ATB-340): functional and proteomic approaches

    Gastric ulcers affect approx. 10% of population. Non-steroidal anti-inflammatory drugs (NSAIDs), including acetylsalicylic acid (ASA) predispose to or impair the physiologically complex healing of pre-existing ulcers. Since H2S is an endogenous …

  2. Open Access 01.12.2024 | OriginalPaper

    Low-dose acetylsalicylic acid reduces local inflammation and tissue perfusion in dense breast tissue in postmenopausal women

    Breast cancer affects more than 10% of all women in the Western world, and its incidence continues to rise [ 1 ]. Although mammography screening programs and improved treatments have reduced the death rate of breast cancer, efficient prevention …

  3. Open Access 08.12.2023 | OriginalPaper

    Early assessment of the pharmacokinetic and pharmacodynamic effects following acetylsalicylic acid loading: toward a definition for acute therapeutic response

    Despite decades of investigations, the optimal assessment of the “therapeutic response” to early after loading dose of acetylsalicylic acid (ASA) remains unclear. Limited information is available on the relation between pharmacodynamic (PD) and …

  4. Open Access 21.08.2023 | OriginalPaper

    Comparison of gastrointestinal adverse events between fast release tablets and regular acetylsalicylic acid (aspirin) galenics after short-term use: a meta-analysis of randomized clinical trials

    This study aimed at determining whether there is a difference in the safety profile between fast release (FR) aspirin tablets and regular galenic formulations of aspirin. This study was based on a clinical study database pool (Bayer HealthCare) …

  5. Open Access 01.12.2020 | Abstract

    P.57 Acetylsalicylic Acid Reduces Passive Aortic Wall Stiffness and Cardiac Remodelling in a Mouse Model of Advanced Atherosclerosis

  6. 09.02.2023 | OriginalPaper

    Acetylsalicylic acid challenge or desensitization in sensitive patients with cardiovascular disease

    The use of acetylsalicylic acid (ASA) is problematic in subjects with histories of hypersensitivity reactions (HRs) to it or with cross-reactive types of nonsteroidal anti-inflammatory drug (NSAID) hypersensitivity. We sought to evaluate the …

  7. Open Access 01.12.2023 | OriginalPaper

    SMA-TB: study protocol for the phase 2b randomized double-blind, placebo-controlled trial to estimate the potential efficacy and safety of two repurposed drugs, acetylsalicylic acid and ibuprofen, for use as adjunct therapy added to, and compared with, the standard WHO recommended TB regimen

    We used the SPIRIT checklist when writing our report [ 1 ]. The numbers in curly brackets in this protocol refer to the SPIRIT checklist item numbers. The order of the items has been modified to group similar items (see …

  8. Open Access 01.10.2022 | OriginalPaper

    The pattern of epistaxis recurrence in patients taking prophylactic acetylsalicylic acid (ASA) from a 10 year cohort

    Epistaxis is one of the most common emergencies in medicine. It mostly affects the elderly and accounts for 1 in 200 general emergency department (ED) visits as well as up to one-third of otolaryngological ED visits [ 1 , 2 ]. One-third of …

  9. Open Access 01.12.2022 | OriginalPaper

    Hypothetical interventions on emergency ambulance and prehospital acetylsalicylic acid administration in myocardial infarction patients presenting without chest pain

    Despite advances in the treatment and survival of patients with myocardial infarction (MI) [ 1 , 2 ], both short and long-term mortality remains high among patients presenting without the cardinal symptom of chest pain [ 3 , 4 ]. MI patients …

  10. 13.07.2022 | Letter

    Bleeding risk in patients with autosomal dominant polycystic kidney disease treated with acetylsalicylic acid: implications for prevention of preeclampsia

  11. 01.08.2021 | OriginalPaper

    Acetylsalicylic Acid Compared with Enoxaparin for the Prevention of Thrombosis and Mechanical Ventilation in COVID-19 Patients: A Retrospective Cohort Study

    The COVID-19 pandemic has had a devastating impact globally. COVID-19 manifests with a wide spectrum of clinical presentations including asymptomatic (40–45%) [ 1 ] or symptomatic, with symptomatic cases further classified as mild (40%), moderate …

  12. Open Access 01.12.2019 | OriginalPaper

    COX2 expression is associated with proliferation and tumor extension in vestibular schwannoma but is not influenced by acetylsalicylic acid intake

    Acetylsalicylic acid has been linked to a lower risk for different cancer types, presumably through its inhibitory effect on cyclooxygenase 2. This has also been investigated in vestibular schwannomas with promising results suggesting an …

  13. Open Access 01.09.2020 | ReviewPaper

    Is Acetylsalicylic Acid a Safe and Potentially Useful Choice for Adult Patients with COVID-19 ?

    Severe Acute Respiratory Syndrome–Coronavirus-2 is responsible for the current pandemic that has led to more than 10 million confirmed cases of Coronavirus Disease-19 (COVID-19) and over 500,000 deaths worldwide (4 July 2020). Virus-mediated …

  14. 01.04.2018 | OriginalPaper

    Chronic Mild Hyperhomocysteinemia Alters Inflammatory and Oxidative/Nitrative Status and Causes Protein/DNA Damage, as well as Ultrastructural Changes in Cerebral Cortex: Is Acetylsalicylic Acid Neuroprotective?

    Homocysteine is a sulfur-containing amino acid derived from methionine metabolism. When plasma homocysteine levels exceed 10–15 μM, there is a condition known as hyperhomocysteinemia, which occur as a result of an inborn error of methionine …

  15. Zur Zeit gratis 29.11.2021 | COVID-19 | OriginalPaper

    Does admission acetylsalicylic acid uptake in hospitalized COVID-19 patients have a protective role? Data from the Spanish SEMI-COVID-19 Registry

    Acetylsalicylic acid (ASA) is widely used in the treatment and prevention of cardiovascular disorders. Our objective is to evaluate its possible protective role, not only in mortality but also in other aspects such as inflammation, symptomatic …

  16. 03.02.2021 | Letter

    Acetylsalicylic acid in essential thrombocythemia

  17. 30.01.2022 | ReviewPaper

    Non-steroidal anti-inflammatory drugs and acetylsalicylic acid increase the risk of complications of diverticular disease: a meta-analysis of case–control and cohort studies

    Diverticulosis is merely the presence of colonic diverticula [ 1 ]. Diverticular disease (DD) describes symptomatic diverticulosis. It ranges from symptomatic uncomplicated diverticular disease (SUDD) to symptomatic complicated diverticular disease …

  18. 04.08.2021 | Erratum

    Correction to: A fatal unsuspected case of acquired A hemophilia. Misleading role of therapy with acetylsalicylic acid?

    In the original publication of the article, the author given name and family name was swapped. The correct author name is given in this erratum.

  19. 07.06.2021 | Letter

    A fatal unsuspected case of acquired A hemophilia. Misleading role of therapy with acetylsalicylic acid?

    Cerebral hemorrhage is a rare event in AHA but described in literature [ 2 ]. In our opinion the characteristics and the severity of the non-traumatic cutaneous hematoma (Fig. 1 ) could not be related exclusively to anti-platelet therapy …

  20. 01.06.2017 | OriginalPaper

    No Effect of Omega-3 Carboxylic Acids on Pharmacokinetics/Pharmacodynamics of Warfarin or on Platelet Function When Co-administered with Acetylsalicylic Acid: Results of Two Phase I Studies in Healthy Volunteers

    Elevated triglyceride levels are associated with an increased risk of cardiovascular events [ 1 , 2 ]. Omega-3 carboxylic acids (OM3-CA)—a complex mixture of fatty acids including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) derived …

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