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Antiphospholipid Syndrome 

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  1. Open Access 01.12.2024 | OriginalPaper

    Insight into antiphospholipid syndrome: the role and clinical utility of neutrophils extracellular traps formation

    Antiphospholipid syndrome (APLS) is a systemic immune dysregulation distinguished by repetitive complications and pregnancy loss in the absence of definite etiology. Most research focuses on the laboratory detection and clinical features of APLS …

  2. 23.02.2024 | ReviewPaper

    Antiphospholipid syndrome, thrombosis, and vaccination in the COVID-19 pandemic

    Thrombosis is one of the many signs of antiphospholipid syndrome (APS) and COVID-19 infection. Although the mechanisms contributing to thrombosis in APS and COVID-19 are relatively similar, this remains an open subject. Even now (when the COVID-19 …

  3. 04.03.2024 | OriginalPaper

    Loss of opportunities in the diagnosis and treatment of primary obstetric antiphospholipid syndrome (POAPS): from theory to reality

    Obstetric antiphospholipid syndrome (OAPS) is a rare autoimmune disorder, characterized by pregnancy morbidity in the presence of antiphospholipid antibodies (aPL) [ 1 ].

  4. Open Access 01.12.2024 | OriginalPaper

    A young woman with acute coronary syndrome and antiphospholipid syndrome. Is it the antiphospholipid syndrome or COVID-19 vaccination or classical risk as the risk factor? a case report

    Acute coronary syndrome (ACS) is historically regarded as a disease more common in men thus causing its underdiagnosis and undertreatment in women [ 1 ]. ACS mainly occurs in elderly patients more than 45 or 50 years old. However, the incidence and …

  5. 22.09.2023 | OriginalPaper

    Non-criteria autoantibodies in antiphospholipid syndrome may be associated with underlying disease activity

    Antiphospholipid syndrome (APS) is an autoimmune disease that is characterized by the presence of circulating antiphospholipid antibodies (aPL). This condition is known to cause a range of vascular and obstetric manifestations due to the …

  6. Open Access 01.12.2024 | OriginalPaper

    Spontaneous coronary artery dissection in a young patient with antiphospholipid syndrome

    A 28-year-old man diagnosed with triple positive antiphospholipid syndrome (APS) and undergoing warfarin experienced three separate admissions to the cardiac ward within a one-month period due to escalating chest pain. While the initial two …

  7. 11.01.2024 | BriefCommunication

    Antiphospholipid syndrome: are old school VKAs still the best choice?

    Thrombotic antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by recurrent arterial and/or venous thrombotic events, with heterogeneous laboratory and clinical manifestations [ 1 ]. The annual rate of first thrombotic …

  8. 01.07.2023 | Letter

    Recurrent reversible cerebral vasoconstriction syndrome and antiphospholipid syndrome

    Reversible cerebral vasoconstriction syndrome (RCVS) represents a cerebral vasculopathy, reversible by definition, characterized by migrating distal-to-proximal vasospasms, clinically expressed by thunderclap headaches and/or other various …

  9. 12.12.2023 | Online First

    Discouraging Non-ELISA antiphospholipid antibody assays in antiphospholipid syndrome classification may hinder clinical research

  10. Open Access 01.12.2024 | OriginalPaper

    A case of repeated in-stent restenosis of coronary artery as a primary manifestation of seronegative antiphospholipid antibody syndrome

    Antiphospholipid antibody syndrome (APS) is defined clinically by the presence of recurrent vascular thrombotic events as well as habitual abortion, and serologically by a positive test for antiphospholipid antibodies (such as lupus anticoagulant …

  11. 10.04.2023 | OriginalPaper

    Evaluation of fetal thymus size in maternal autoimmune diseases: systemic lupus erythematosus, Sjögren’s syndrome and antiphospholipid antibody syndrome

    Autoimmune diseases are caused when the body’s immune system reacts against its own cells and tissues, resulting in inflammation and tissue damage [ 1 , 2 ]. While afflicting about 5% of society, the most affected group is women of childbearing …

  12. 11.05.2023 | Letter

    “Non-criteria” antiphospholipid syndrome and autoimmune hemolytic anemia: a case report

    Antiphospholipid syndrome (APS) is characterized by a moderate to high titer of antiphospholipid antibody (aPL) and usually presents as recurrent arterial, venous thrombosis, and spontaneous abortion [ 1 ]. “Non-criteria” APS is proposed when …

  13. Open Access 23.09.2023 | ReviewPaper

    The effects of hydroxychloroquine and its promising use in refractory obstetric antiphospholipid syndrome

    Hydroxychloroquine (HCQ) is obtained by hydroxylation of chloroquine (CQ) and the first indication was malaria. Nowadays, HCQ is commonly used in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) with favorable results.

  14. Open Access 01.12.2023 | OriginalPaper

    Bilateral adrenal infarction and insufficiency associated with antiphospholipid syndrome and surgery: a case report

    Antiphospholipid syndrome (APS) is an autoimmune disease that causes systemic arterial and venous thromboses due to antiphospholipid antibodies (aPL). Adrenal insufficiency (AI) is a rare complication of APS that occurs in only 0.4% of patients [ 1 …] and can lead to fatal outcomes if left untreated. The mortality rate of APS complicated with AI is 3.81% [

  15. Open Access 27.09.2023 | ReviewPaper

    Celiac trunk thrombosis in a patient with antiphospholipid syndrome induced by median arcuate ligament compression: a case presentation and literature review

    Median arcuate ligament syndrome (MALS) is a rare disorder caused by the compression of the celiac axis by the fibrous structure of the diaphragm called the median arcuate ligament. Patients with MALS are usually undiagnosed unless characteristic …

  16. Open Access 31.10.2023 | OriginalPaper

    Serum Calprotectin as a Potential Predictor of Microvascular Manifestations in Patients with Antiphospholipid Syndrome

    Antiphospholipid syndrome (APS) is a rare and complicated autoimmune disease characterized by arterial/venous thrombosis and/or recurrent pregnancy morbidity with antiphospholipid antibody (aPL) positivity. Except for thrombotic APS (tAPS) and …

  17. 17.10.2023 | Online First

    Thrombotic microangiopathy due to primary antiphospholipid syndrome: successful treatment with eculizumab

    Antiphospholipid syndrome nephropathy includes a variety of histological lesions, including thrombotic microangiopathy, which is not included among the diagnostic criteria of antiphospholipid syndrome. Whereas in secondary antiphospholipid

  18. Open Access 01.12.2023 | OriginalPaper

    Cutaneous microvascular occlusion syndrome as the first manifestation of catastrophic lupus-associated antiphospholipid antibody syndrome: a case report

    Antiphospholipid syndrome (APS) is a rare autoimmune condition in children. Pediatric APS appears to be under-recognized because there are no universally accepted and verified criteria. For most researchers, the term "pediatric APS" applies if the …

  19. Open Access 01.12.2023 | OriginalPaper

    Lupus mastitis and antiphospholipid syndrome treated with anticoagulation and immunosuppression: a case report

    Lupus mastitis is a rare form of panniculitis occurring in patients with systemic or discoid lupus. Lupus panniculitis refers to inflammation of the subcutaneous fat and is termed lupus mastitis when affecting the breasts. There have been 36 cases …

  20. 12.08.2023 | Online First

    Antiphospholipid Syndrome: State of the Art of Clinical Management

    Antiphospholipid syndrome (APS) is a systemic autoimmune disorder clinically characterized by recurrent arterial and venous thrombosis and/or pregnancy morbidity in the presence of antiphospholipid antibodies. Currently, treatment is mainly …

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e.Medpedia

Sekundäres Raynaud-Phänomen

Klinische Angiologie
Das sekundäre Raynaud-Phänomen (RP) zeigt initial häufig eine vergleichbare Klinik wie das primäre RP, es ist aber als Folge einer zugrunde liegenden Erkrankung aufzufassen. Bisweilen manifestiert sich die Erkrankung erst Jahre nach dem ersten Auftreten eines RP. Innerhalb von 10 Jahren wird bei etwa 10 % der Patienten mit RP eine Grunderkrankung manifest. Patienten mit ungewöhnlicher Konstellation bei Erstmanifestation haben ein höheres Risiko. Kollagenosen gehen häufig mit einem RP einher, die Systemische Sklerose in über 90 %. In der Abklärung helfen neben Anamnese und körperlicher Untersuchung die Kapillarmikroskopie und Autoantikörperdiagnostik. Therapieprinzipien des primären RP werden übernommen, in einigen Fällen sollte auch die Grunderkrankung intensiver behandelt werden.

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