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Drug Interaction 

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  1. Open Access 12.04.2024 | Online First

    Enzalutamide: Understanding and Managing Drug Interactions to Improve Patient Safety and Drug Efficacy

    Enzalutamide is an oral androgen receptor signaling inhibitor utilized in the treatment of men with prostate cancer. It is a moderate inducer of the cytochrome P450 (CYP) enzymes CYP2C9 and CYP2C19, and a strong inducer of CYP3A4. It was also …

  2. 01.04.2024 | News

    Drug interactions between Paxlovid and immunosuppressants

  3. 30.03.2024 | OriginalPaper

    Management of direct oral anticoagulant drug interactions in hospitalized patients

    Moderate-strong CYP3A4 or Pgp inhibitors and inducers alter direct oral anticoagulant (DOAC) pharmacokinetics. Whether the presence of a DOAC drug-drug interaction (DDI) prompts in- hospital changes in management remains unknown. We identified all …

  4. 03.11.2023 | Letter

    Pharmacokinetic drugdrug interaction between olaparib and apixaban: a case report

  5. Open Access 30.04.2024 | Online First

    Timing Matters: A Machine Learning Method for the Prioritization of DrugDrug Interactions Through Signal Detection in the FDA Adverse Event Reporting System and Their Relationship with Time of Co-exposure

    Drugdrug interactions (DDIs) pose a significant concern in healthcare, as the concomitant use of multiple medications can lead to adverse events (AEs) and compromised therapeutic outcomes [ 1 ]. To identify and assess DDIs, spontaneous reporting …

  6. Open Access 25.01.2024 | ReviewPaper

    Drug-Drug Interactions Between Glucagon-Like Peptide 1 Receptor Agonists and Oral Medications: A Systematic Review

    Glucagon-like peptide 1 receptor agonists (GLP1RAs) are widely used in the treatment of diabetes mellitus (DM) and obesity [ 1 , 2 ]. Beyond glucose control and weight reduction, GLP1RAs were shown to reduce cardiovascular morbidity and mortality …

  7. 08.03.2024 | ReviewPaper

    Anti-Calcitonin Gene-Related Peptide Monoclonal Antibodies in Migraine: Focus on Drug Interactions

    Calcitonin gene-related peptide neurotransmission was the target for recent development of monoclonal antibodies that effectively prevent attacks of both episodic and chronic migraine. The aim of this narrative review was to offer deeper insight …

  8. Open Access 03.04.2024 | OriginalPaper

    The Gut Microbiota in Parkinson Disease: Interactions with Drugs and Potential for Therapeutic Applications

    The concept of a ‘microbiota-gut-brain axis’ has recently emerged as an important player in the pathophysiology of Parkinson disease (PD), not least because of the reciprocal interaction between gut bacteria and medications. The gut microbiota can …

  9. Open Access 01.12.2024 | OriginalPaper

    Polypharmacy, drug-drug interactions, anticholinergic burden and cognitive outcomes: a snapshot from a community-dwelling sample of older men and women in northern Italy

    Polypharmacy (PP) use is very common in older people and may lead to drug-drug interactions (DDIs) and anticholinergic burden (ACB) that may affect cognitive function. We aimed to determine the occurrence of PP, potential DDIs and ACB and their …

  10. Open Access 01.12.2024 | OriginalPaper

    Identification of therapeutic targets in osteoarthritis by combining heterogeneous transcriptional datasets, drug-induced expression profiles, and known drug-target interactions

    Osteoarthritis (OA) is the predominant joint disease in middle-aged and older people, and the risk of being affected dramatically increases with aging [ 1 – 4 ]. Often labeled “wear and tear” disorder, it is defined as a hypertrophic, complex, and …

  11. Open Access 27.11.2023 | OriginalPaper

    DrugDrug Interaction Studies of Esmethadone (REL-1017) Involving CYP3A4- and CYP2D6-Mediated Metabolism

    Major depressive disorder is a functionally severely disabling condition characterized by depressed mood, loss of interest in activities of daily life, lack of motivation, and cognitive dysfunction. It has been estimated that approximately 70% of …

  12. Open Access 19.02.2024 | Report

    Outcomes of Drug Interactions Between Antiretrovirals and Co-Medications, Including Over-the-Counter Drugs: A Real-World Study

    A substantial number of persons with HIV (PWH) may use combinations of drug combinations that may result in clinically relevant drugdrug interactions (DDIs) [ 1 ], potentially increasing the risk of treatment failure or undesired adverse effects …

  13. Open Access 25.01.2024 | OriginalPaper

    Midostaurin drug interaction profile: a comprehensive assessment of CYP3A, CYP2B6, and CYP2C8 drug substrates, and oral contraceptives in healthy participants

    The anti-leukemic agent midostaurin (Rydapt®) is a multi-targeted tyrosine kinase inhibitor that has been approved in more than 60 countries worldwide. It is used for the treatment of fms-related receptor tyrosine kinase 3 ( FLT-3 )-mutated acute …

  14. Open Access 13.03.2024 | Online First

    DrugDrug Interactions and Actual Harm to Hospitalized Patients: A Multicentre Study Examining the Prevalence Pre- and Post-Electronic Medication System Implementation

    Drugdrug interactions (DDIs) have the potential to cause patient harm, including lowering therapeutic efficacy [ 1 – 3 ], and are associated with greater length of hospital stay and healthcare costs [ 4 ]. A US national study of more than 2 …

  15. 18.01.2024 | Letter

    Comment on: Anti-Coagulant Treatment of Cancer-Associated Thrombosis in Frail Patients: Impact of Frailties on the Management of DrugDrug Interactions

  16. Open Access 01.12.2024 | OriginalPaper

    A case report of drug interaction between co-packaged nirmatrelvir-ritonavir and tacrolimus causing hyponatremia in a lung transplant recipient

    The outcomes of lung transplant recipients infected with coronavirus disease 2019.

  17. 20.02.2024 | OriginalPaper

    Pharmacokinetics of Dasatinib in Rats: a Potential Food–Drug Interaction with Naringenin

    Tyrosine kinases (TKs) are important cell cycle regulators and are thought to control metabolism, cell division, growth, and apoptosis [ 1 ]. TKs are often dysregulated (through either overexpression or somatic mutations) in various cancers [ 2 ].

  18. 01.02.2024 | News

    Statin and ticagrelor drug interaction increases risk of rhabdomyolysis

  19. 01.02.2024 | News

    PRAC meeting Feb 2024: reminder of Paxlovid drug interactions

  20. 05.03.2024 | Online First

    Correction to: Midostaurin drug interaction profile: a comprehensive assessment of CYP3A, CYP2B6, and CYP2C8 drug substrates, and oral contraceptives in healthy participants

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e.Medpedia

Precision Oncology: Grundlagen und Klassifikationen

Die Urologie
Die Präzisions-Onkologie steht für eine zielgerichtete, hoch-effektive sowie nebenwirkungsarme Tumortherapie. Ziel der molekularen Präzisionsonkologie ist die Beeinflussung eines definierten, direkten oder indirekten tumorspezifischen Zielmoleküls. Voraussetzung für diese Entwicklung ist die Identifizierung von klinisch relevanten, funktionalisierten Zielstrukturen in der Pathogenese onkologischer Erkrankungen, die Implementierung von prädiktiven Biomarkern sowie die Translation der gewonnenen Daten (einschließlich Hochdurchsatzverfahren). In diesem Kapitel soll näher auf die Prinzipien der medikamentösen, präzisionsonkologischen Therapiemöglichkeiten eingegangen werden, welche aktuell im Rahmen molekularer Tumorboards an universitären Zentren stattfindet bzw. vorangetrieben werden.

Suchoperatoren:

„ ... ... “ Findet Dokumente mit genau dieser Wortgruppe in exakt dieser Schreibweise und Reihenfolge (z.B., "rheumatische Beschwerden").
AND / UND Findet Dokumente, in denen beide Begriffe zusammen vorkommen (z.B., alkohol UND demenz).
OR / ODER Findet Dokumente, in denen einer der beiden oder beide Begriffe vorkommen (z.B., hiv ODER aids).
Leerzeichen Findet Dokumente, in denen alle Begriffe vorkommen. Der Leerschritt wird als UND interpretiert (z.B., isolierte systolische hypertonie).
NOT / NICHT Findet Dokumente, in denen der Begriff nach NOT nicht vorkommt (z.B., sars NOT sars-cov-2).
COUNT(...)>n Findet Dokumente, in denen der gesuchte Begriff mehr als n mal vorkommt. n steht für eine beliebige Anzahl (z.B., COUNT(mammakarzinom)>8).
NEAR(..., ..., ) Findet Dokumente, in denen beide Begriffe in beliebiger Reihenfolge innerhalb von maximal n Worten zueinander stehen. Empfehlung: wählen Sie zwischen 15 und 30 als maximale Wortanzahl (z.B., NEAR(covid, diabetes,20)).
* Findet Dokumente, in denen der Begriff in Wortvarianten vorkommt, wobei diese VOR, HINTER oder VOR und HINTER dem Suchbegriff anschließen können (z.B., thrombose*, *thrombose, *thrombose*).
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