Introduction
Materials and methods
Study design
Patients and settings
Ethics, consent, and permissions
Clinical management
Analyses
Definitions and formulae
Statistics
Results
General
Hip arthroplasty
|
Knee arthroplasty
|
p
value
| |
---|---|---|---|
n = 114
|
n = 79
|
(hip vs. knee)
| |
Male gender
| 62 (54%) | 32 (41%) | 0.058 |
Preop medication
| |||
NSAID
| 30 (26%) | 16 (20%) | 0.33 |
Acetylsalicylic acid
| 18 (16%) | 18 (23%) | 0.22 |
SSRI
| 10 (9%) | 9 (11%) | 0.55 |
Thromboprophylaxis
| |||
Dabigatran
| 104 (91%) | 75 (95%) | 0.33 |
LMWH
| 10 (9%) | 4 (5%) | |
Anesthesia
| |||
Spinal
| 95 (83%) | 65 (82%) | 0.85 |
General
| 19 (17%) | 14 (18%) | |
BMI
(kg/
m
2
)
| 27 ± 4.1 (17–40) | 30 ± 4.5 (22–49) |
<0.001
|
Age
(years)
| 66 ± 12 | 69 ± 10 | 0.086 |
Hemoglobin
(g/
L)
| 136 ± 13 | 133 ± 12 | 0.24 |
Platelet count
(10
9
/L)
| 283 ± 65 | 280 ± 72 | 0.81 |
PT
(INR)
| 1.0 ± 0.1 | 1.0 ± 0.1 | 0.77 |
aPTT
(s)
| 34 ± 3.8 | 33 ± 3.3 | 0.57 |
Operation time
(min)
| 125 ± 28 | 113 ± 28 |
0.004
|
RBC transfusion
| 21 (18%) | 9 (11%) | 0.18 |
RBC transfusion
(units)
| 0 (0–4) | 0 (0–3) | 0.22 |
EBL
(mL)
| 984 (0–4571) | 789 (0–1927) |
0.001
|
EBL/
kg (
mL
/kg)
| 12 (0–33) | 9 (0–23) |
<0.001
|
Cellsaver (
mL)
| 0 (0–1200) | 0 |
0.007
|
Bleeding and estimated blood loss
Excessive bleeding
(EBL/
kg >
17.1 mL/
kg)
|
Allogeneic RBC transfusion
| |||||
---|---|---|---|---|---|---|
OR
|
95%
CI
|
p
value
|
OR
|
95%
CI
|
p
value
| |
Age
(years)
| 1.00 | 0.99–1.07 | 0.11 | 1.05 | 1.01–1.10 |
0.022
|
Sex
(F)
| 3.39 | 1.37–8.38 |
0.008
| 7.04 | 2.19–22.63 |
0.001
|
BMI
(kg/
m
2)
| 0.83 | 0.73–0.95 |
0.006
| 0.90 | 0.79–1.03 | 0.13 |
Weight
(kg)
| 0.92 | 0.89–0.96 |
<0.001
| 0.94 | 0.91–0.98 |
0.003
|
NSAID
(No)
| 1.42 | 0.51–3.93 | 0.50 | 0.66 | 0.24–1.83 | 0.42 |
ASA
(No)
| 1.17 | 0.35–3.89 | 0.80 | 0.75 | 0.22–2.57 | 0.65 |
SSRI
(No)
| 0.45 | 0.12–1.73 | 0.24 | 0.29 | 0.08–1.15 | 0.079 |
Hemoglobin
(g/
L)
| 0.97 | 0.94–1.01 | 0.12 | 0.87 | 0.82–0.93 |
<0.001
|
Platelet count
(10
9
/L)
| 1.01 | 1.00–1.01 | 0.17 | 1.00 | 1.00–1.01 | 0.52 |
PT
(INR)
| 0.76 | 0.001–70.9 | 0.90 | 0.03 | 0.00–7.71 | 0.21 |
aPTT
(s)
| 1.01 | 0.90–1.13 | 0.87 | 1.05 | 0.93–1.17 | 0.45 |
Operation time
(minutes)
| 1.02 | 1.00–1.04 |
0.017
| 1.02 | 1.00–1.03 | 0.065 |
Anesthesia
(spinal)
| 0.89 | 0.29–2.75 | 0.85 | 0.82 | 0.24–2.77 | 0.75 |
EBL/
kg
| n.a. | 1.17 | 1.09–1.26 |
<0.001
|
Excessive bleeding
(EBL/
kg >
12.7 mL/
kg)
|
Allogeneic RBC transfusion
| |||||
---|---|---|---|---|---|---|
OR
|
95%
CI
|
p
value
|
OR
|
95%
CI
|
p
value
| |
Age
(years)
| 1.02 | 0.97–1.08 | 0.45 | 0.99 | 0.92–1.06 | 0.79 |
Sex
(F)
| 0.69 | 0.24–1.95 | 0.49 | 0.29 | 0.068–1.28 | 0.10 |
BMI
(kg/
m
2
)
| 0.81 | 0.69–0.95 |
0.010
| 0.78 | 0.62–0.98 |
0.034
|
Weight
(kg)
| 0.96 | 0.92–1.0 |
0.046
| 0.97 | 0.92–1.02 | 0.26 |
NSAID
(No)
| 0.94 | 0.26–3.34 | 0.92 | 0.88 | 0.16–4.68 | 0.88 |
ASA
(No)
| 1.14 | 0.32–4.0 | 0.84 | 2.57 | 0.3–22.02 | 0.39 |
SSRI
(No)
| 1.12 | 0.21–5.93 | 0.89 | 1.03 | 0.11–9.37 | 0.98 |
Hemoglobin
(g/
L)
| 1.09 | 1.03–1.16 |
0.001
| 0.91 | 0.84–0.97 |
0.007
|
Platelet count
(10
9
/L)
| 1.0 | 0.99–1.01 | 0.56 | 1.001 | 0.99–1.01 | 0.88 |
PT
(INR)
| 0.001 | 0.00–1.03 | 0.051 | 0.036 | 0–220.4 | 0.46 |
aPTT
(s)
| 0.91 | 0.78–1.07 | 0.26 | 1.34 | 1.03–1.74 |
0.028
|
Operation time
(minutes)
| 1.00 | 0.98–1.02 | 0.87 | 1.03 | 1.00–1.06 |
0.034
|
Anesthesia
(spinal)
| 2.12 | 0.43–10.48 | 0.35 | 0.72 | 0.13–3.92 | 0.71 |
EBL/
kg
| n.a. | 1.020 | 0.88–1.18 | 0.795 |