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23.01.2018

Transplantation in patients with iron overload: is there a place for magnetic resonance imaging?

Transplantation in iron overload

verfasst von: Sophie Mavrogeni, Genovefa Kolovou, Boris Bigalke, Angelos Rigopoulos, Michel Noutsias, Stamatis Adamopoulos

Erschienen in: Heart Failure Reviews | Ausgabe 2/2018

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Abstract

In iron overload diseases (thalassemia, sickle cell, and myelodysplastic syndrome), iron is deposited in all internal organs, leading to functional abnormalities. Hematopoietic stem cell transplantation (HSCT) is the only treatment offering a potential cure in these diseases. Our aim was to describe the experience in the field and the role of magnetic resonance imaging in the evaluation of iron overload before and after HSCT. Magnetic resonance imaging (MRI), using T2*, is the most commonly used tool to diagnose myocardial-liver iron overload and guide tailored treatment. Currently, HSCT offers complete cure in thalassemia major, after overcoming the immunologic barrier, and should be considered for all patients who have a suitable donor. The overall thalassemia-free survival of low-risk, HLA-matched sibling stem cell transplantation patients is 85–90%, with a 95% overall survival. The problems of rejection and engraftment are improving with the use of adequate immunosuppression. However, a detailed iron assessment of both heart and liver is necessary for pre- and post-transplant evaluation. In iron overload diseases, heart and liver iron evaluation is indispensable not only for the patients’ survival, but also for evaluation before and after HSCT.

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Titel: Transplantation in patients with iron overload: is there a place for magnetic resonance imaging?
Transplantation in iron overload
verfasst von: Sophie Mavrogeni
Genovefa Kolovou
Boris Bigalke
Angelos Rigopoulos
Michel Noutsias
Stamatis Adamopoulos
Publikationsdatum: 23.01.2018
Verlag: Springer US
Erschienen in: Heart Failure Reviews / Ausgabe 2/2018
Print ISSN: 1382-4147
Elektronische ISSN: 1573-7322
DOI: https://doi.org/10.1007/s10741-018-9670-7

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Weitere Artikel der Ausgabe 2/2018

Effect of aerobic and resistance training on inflammatory markers in heart failure patients: systematic review and meta-analysis

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