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01.10.2012 | Original Article

Treatment-related side effects and quality of life in cancer patients

verfasst von: Eva Mazzotti, Gian Carlo Antonini Cappellini, Stefania Buconovo, Roberto Morese, Alessandro Scoppola, Claudia Sebastiani, Paolo Marchetti

Erschienen in: Supportive Care in Cancer | Ausgabe 10/2012

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Abstract

Background

Cancer leads to a complicated pattern of change in quality of life (QoL).

Objective

The aims of this study were to assess the impact of treatment-related side effects on QoL in cancer patients and to explore which other factors, and to what extent, contribute to explain low QoL scores.

Methods

One hundred twenty-three cancer patients receiving chemotherapy completed the self-administered questionnaires (Medical Outcomes Short-Form-36 (SF-36) and 12-item General Health Questionnaire). Multiple regression analyses were conducted with the SF-36 physical component summary (PCS) and SF-36 mental component summary (MCS) scores as the dependent variables and demographic and clinical factors as independent variables.

Results

Seventy-two percent of patients experienced treatment-related side effects, and 32% resulted positive for psychiatric diseases. Two multivariate analyses showed that worse PCS scores, like worse MCS scores, were significantly and independently predicted by treatment-related side effects (odds ratio (OR) = 5.00, 95%CI 1.29–19.45; OR = 8.08, 95%CI 2.03–32.22, respectively) and changes in health over the last 12 months (OR =2.34, 95%CI 1.47–3.76; OR = 3.21, 95%CI 1.90–5.41, respectively), after adjustment for age, gender, years of school, time from cancer diagnosis, and psychiatric disease.

Conclusions

Given the new emphasis on QoL, we suggest that physicians have a responsibility to openly discuss therapy efficacy, prognosis as well as the potential for adverse events with their patients. Changes in health, as perceived by patient, should also be monitored at follow-up.

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Titel: Treatment-related side effects and quality of life in cancer patients
verfasst von: Eva Mazzotti
Gian Carlo Antonini Cappellini
Stefania Buconovo
Roberto Morese
Alessandro Scoppola
Claudia Sebastiani
Paolo Marchetti
Publikationsdatum: 01.10.2012
Verlag: Springer-Verlag
Erschienen in: Supportive Care in Cancer / Ausgabe 10/2012
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-011-1354-y

Springer Medizin

Treatment-related side effects and quality of life in cancer patients