Background
Due to the rapid increase in the incidence of thyroid cancer (TC), TC is now considered as a major public health problem worldwide [
1‐
3]. From a clinical perspective, TC is also a malignant tumor caused by follicular or parathyroid thyroid cells. In the recent past decades, the incidence of TC has been steadily increasing globally, especially among women [
3‐
7]. Previous studies also indicated a significant increase in the incidence of TC in the Chinese population [
8]. The incidence of TC in women is higher (3.8 per 100,000) than that in Chinese men (1.1 per 100,000). This difference may be attributed to female reproductive hormones. It is speculated that the increased levels of the female hormone caused by reproductive events trigger the thyroid hormone levels, which can cause thyroid dysplasia and eventually lead to cancer outbreaks [
9]. In many middle and high-income countries, the incidence of TC has been growing rapidly, the incidence of thyroid cancer has risen sharply in the U. S, from 3.6 cases per 100,000 in 1973 to 15 cases per 100,000 in 2014. From a previous study, about 62,450 new cases of TC are reported by the American Cancer Society [
10]. In the U.S., women have doubled or tripled in just a few decades. According to some reports, the recent incidence has increased slightly in the U.S. [
6,
11]. Meanwhile, the U.S. is one of the representative countries with a high TC incidence. In the U.S. and China, the incidence of TC varies greatly globally, and there is the largest difference between urban and rural areas in China [
12].
The 2015 annual report of the Chinese Cancer Registry shows that TC has become one of the top ten cancers that seriously threaten the health of Chinese residents, and it is particularly serious in some provinces such as Zhejiang, with women ranking the first. Therefore, we choose two representative countries to describe the trend of the TC in order to further control and study the incidence of TC [
13].
Many studies have different opinions about the influence of age, period and cohort on the incidence of TC. It is believed that the increase in the incidence of TC may be due to over diagnosis [
14,
15]. However, environmental factors may lead to an increase in the incidence of TC [
16,
17]. In order to assess the trend dynamic of TC incidence due to underlying reasons, we analyzed the temporal changes of TC from 1990 to 2017, stratified by sex and age group using Joinpoint and age-period-cohort model in China and the U.S. population.
Discussion
In our study, we analyzed the temporal trends and the changes in the incidence of TC in China and the U. S. from 1990 to 2017. Among Chinese men, 2006–2011 was a surprisingly “Joinpoint”. The reason for the significant upward is most likely the frequency of medical diagnostic and therapeutic nuclear medicine resulting in an increased incidence of TC [
27]. In recent years, the incidence rate of the two countries has been steadily slowing down. It can be seen that China and the U.S. have implemented policies to improve cancer screening. We also found that from 1992 to 2017, the incidence of ASIR of TC in China and in the U. S. was higher in women than in men and still at a relatively higher level. We observed the incidence of TC vary by sex, and estrogen levels of women may be one of the risk factors for TC [
28]. In addition, a study is similar to our results. The long-term trend for women is greater, while the age-related trend for men is greater [
29]. Otherwise, Joinpoint regression analysis presented incidence rates increased in both men and women from 1992 to 2017, while incidence rates obviously increased in Chinese men mainly from 2006 to 2011. Because the important interaction between age, period and cohort effect, we use an age-period-cohort model and IEalgorithm to explore the impact of these factors on the incidence of TC. Therefore, it is necessary to further analyze the causes and differences of these trends in the model, and further explore the risk factors leading to the occurrence of TC disease. In general, the incidence of TC increases with age and period, especially the 40–75 age groups of men in the U.S. The men showed a significant upward trend from 2007 to 2017, but decreased with the birth cohort in China.
Based on our findings, the incidence of TC increased with the age of men and women, and China’s aging may exacerbate this situation [
30]. Chinese men have a higher risk of TC in the 40–55 age group, probably because residents between the ages of 40–59 paid more attention to physical examination, and the detection rate in cities are higher than in rural areas [
31]. The rapid rise in age RRs of Chinese men for the 70–79 age group is due to the most variability of cancer prognosis in the old ages and the highest risk of TC treatment. Among the female population in China, the fastest growth was in women of childbearing age, which is consistent with the results of other countries [
15]. The rapid increase RRs of 20–30 age groups of women may be an annual obstetric and gynecological examination during reproduction in China. The risk of TC in women increases during puberty, but decreases after menopause. Among young women, the incidence of TC ranks first among malignant tumors. It is suggested that hormone factors are involved in TC, and estrogen increases thyroid growth [
32]. According to our results, old people had a higher risk of TC than young. The age effects may increase the risk of illness in the elder people. In addition, increased complications of TC are existed in older TC patients than in younger patients. China’s aging is growing faster than the U.S., the trend of population growth and aging is increasing in China [
33]. Therefore, we may pay more attention to prevention and control the occurrence of the TC in the old age people.
The RRs of TC in women increased rapidly with the age of before 45-year-old age group in the U.S. However, the RRs of TC decreased rapidly after the 60-year-old, which may indicate that estrogen levels play a role in the development of TC. There were obvious gender differences in the incidence of TC. Women were 2–3 times more likely than men for TC incidence from 1992 to 2017. It further indicates that TC may be related to estrogen [
34]. The age RRs of TC for U.S. men increased slowly from 20 to 49 years but increased rapidly after 50 years of age. Therefore, among men over 50 years old, the diagnosis rate of papillary TC is high, but over diagnosis is rare among men between 20 and 49 years old in the U. S. Among patients with TC in the U. S., the majority of patients in diagnosis were 45–49 age groups for women and 55–59 age groups for men [
35]. The difference in age and gender may be that middle-aged women use more health care services than men. This difference is also a result of reproductive activity and menopause, leading to earlier diagnosis [
7,
36]. Moreover, compared with women, men tend to pay more attention to their health when they get old. According to a study, the increased TC incidence rates have been reported among young people and adults in the U.S. [
37], which shows that some risk factors, such as high body mass index (BMI), [
38] ionizing radiation, [
39] may have contributed to increasing TC incidence rate.
The period effect means that unique medical technology, diagnostic methods, economic and cultural changes in a specific period can increase the risk of TC. Environmental factors are closely related to TC, that is, exposure to ionizing radiation is one of the TC risk factors [
40,
41]. On the whole, the period RRs of men and women in China is on the rise. From 1992 to 2008, the frequency of medical diagnostic and therapeutic nuclear medicine in China has been increasing, resulting in a significant increase in the annual personal radiation dose [
42]. It is not difficult to find that the period effect of men and women after 2007 in China has a clear rising trend. Among them, men showed a slow upward trend after 2012, while women increased significantly from 2007 to 2017. A previous study conducted in China reported that in 2008, about 17% of people over the age of 15 had regular physical examinations, 68% had a physical examination every 7–12 months, and one-third of the population conducted X-rays. More frequent nuclear medical examinations may lead to increasing radiation exposure, resulting in an increased incidence of TC [
27]. With the acceleration of China’s industrialization process, the exposure to risk factors is becoming more and more obvious [
43]. From 1992 to 2017, men’s carcinogens increased significantly. The rising incidence of men may be due to cancer caused by occupational diseases [
18]. Over the past 25 years, environmental exposure caused by industrial activities of industrial density may have affected the incidence of TC, which is an occupational carcinogen. TC is considered a cancer that can be affected by occupational exposure. In addition, the GBD study also showed that cancer death and disability-adjusted life years (DALYs) due to occupational risks began to increase around 2007. In fact, occupational exposure has increased since 2007 [
44]. Especially, male workers who are exposed to certain solvents and pesticides have an increased risk of developing thyroid tumors. Period RRs showed a remarkable increasing trend of Chinese men, which may be caused by occupational carcinogens. Therefore, it is necessary to minimize the exposure of men to occupational carcinogens in China [
45].
In the U. S., men and women period effects have a similar upward trend. TC is one of the ten most common cancers in the U.S. From 1990 to 2017, the incidence of TC has been increasing at a higher rate than any other malignant tumor. The survey data of the U.S. from 2003 to 2009,revealed that the 5-year survival rate of TC reached up to 98.2% [
46]. The steady growth trend of men and women may be due to the rise in the economy of the U.S. The increased incidence of TC was caused by over diagnosis from 1990 to 2000 [
35]. The socio-economic progress of the U.S. is rapidly increased. In general, people with higher socioeconomic status are more likely to access health care services, and have increased contact with the health care system, leading to an increased risk of over diagnosis. A positive correlation is existed between socioeconomic status and TC risk [
47].
The cohort effect represents the impact of early life economic level, living habits and environmental factors on the risk of TC. Early in life exposure to adverse risk factors may affect future life [
48]. Men and women simultaneously increased the risk of morbidity in the cohort effect. This may be linked to China’s economic development and related environmental and cultural changes. One stage was from 1943 to 1947 to 1948–1952, which was considered the period of the War of Resistance against Japan and the period of the National Liberation War. After a long period of war, the living environment has deteriorated and health problems have become more difficult to defend. In addition, during the periods of 1958–1962 and 1963–1967, China experienced a series of social and economic system changes, and the three-year natural disasters from 1959 to 1961, due to the sacrifice of agriculture and industrial development policies, this led to a nationwide food shortage crisis. Therefore, health risk factors have increased significantly [
49]. At the same time, this disaster has also aggravated the spread of some infectious diseases, which has adverse effects on people’s health and industrial and agricultural production. In terms of gender differences in China, we found that women in the early cohort had a lower risk of incidence than men incidence. After the birth cohort in 1933–1937, the risk of women in the incidence began to be higher than that of men, and in the birth cohort after 1978–1982, the risk of women began to be lower than that of men. Obviously, women greatly reduced the risk of the birth cohort after 1952. It may be due to the establishment of the employee medical security system in China and the improvement of the Chinese medical system at that time [
50,
51]. During this period, China launched an important patriotic public health campaign, which greatly improved the health of residents and decreased the risk of developing TC by carrying out pest control, health education and health promotion [
52].. The increased risk of incidence in later-born men is related to social disintegration and later-born men are more likely to be exposed to smoking, drinking, and other risk factors that lead to higher risk levels. Complex interactions between these risk factors may lead to increasing TC risk of Chinese men [
53]. In the U. S., ultraviolet radiation may be one of the risk factors for TC. Because, since 1960s, the availability of medical services in the U.S., new equipment and complex diagnostic tests has increased, the number of X-rays for medical examinations and care has dramatically increased [
54]. We found that people over the age of 40 are more likely to be exposed to ultraviolet radiation than younger people. It reflects that the cohort effect of the TC is on declining trend [
55]. During 1913–1917 and 1993–1997, the incidence of TC for men and women showed a continuous downward trend in the U.S. The possible reason is that the recently born cohort is well-educated and gains a better understanding of health and disease prevention [
56]. People born after 1973 have a reduced risk of TC incidence in China and the U.S. Previous studies can be seen that under the influence of changes in medical practice and improved diagnostic technology of TC, with the introduction of thyroid ultrasound and the emergence of needle aspiration technology in the 1980s, the sensitivity of diagnosis and detection opportunities have improved [
29,
57].
Since the 1990s, the incidence of TC has been growing faster than other types of cancer in the U. S as far as China is worried, TC ranks seventh in the incidence of malignant tumors. China holds the largest number of deaths from TC in the world. The results of recent studies show that the countries with the highest incidence of TC are China and the U.S., and the global rise of TC incidence is related to geographic factors. The incidence of TC in China is also significantly different based on gender and age. Therefore, more evidence-based studies are required to confirm the existing findings regrading TC trends in these countries [
1,
58,
59].
Limitations
We acknowledge that our research has certain limitations.. Firstly, the data used in this study are based on the latest data from GBD 2017, which uses incidence data from the Cancer Registry. The accuracy of the diagnosis is still biased, which will lead to the problem of decreased data accuracy. Secondly, our research on TC had no specific cancer subdivisions or in-depth research on the factors that lead to changes in TC, so we cannot make causal inferences. Despite its limitations, our study is still an indispensable national study, which aims to compare the trends and changes in the incidence of TC in China and the U.S.
Publisher’s Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.