nach oben

Endocrine

Erschienen in:

07.03.2022 | Original Article

Triglyceride to high-density lipoprotein cholesterol ratio in adolescence as a predictive marker of metabolic syndrome and obesity in early adulthood in China

verfasst von: Fang Zhou, Xiaoshi Sun, Juan Liu, Linlin Li, Ling Li, Ping Li

Erschienen in: Endocrine | Ausgabe 2/2022

Einloggen, um Zugang zu erhalten

Abstract

Objective

To explore serum triglyceride (TG) to high-density cholesterol (HDL-C) ratio as a diagnostic marker of metabolic syndrome (MetS) in adolescents and its efficacy in predicting MetS and obesity in the early adulthood.

Methods

A stratified cluster random sampling method was used to select a total of 935 subjects from senior and junior high schools in Liaoyang, northeast China. The subjects were physically examined and laboratory evaluation was performed. A follow-up examination was performed after 5 years on some (n = 93) of the subjects who had reached adulthood.

Results

TG/HDL-C had significantly high diagnostic accuracy for MetS than HOMA-IR, TG or HDL-C. Subjects with the highest TG/HDL-C at baseline had higher risk of MetS (odds ratio [OR] = 11.65) and obesity (OR = 4.32) in early adulthood.

Conclusion

TG/HDL-C ratio has a strong and independent ability in diagnosing MetS in adolescents and predicting the occurrence of MetS and obesity in their early adulthood.

Nur mit Berechtigung zugänglich

J. Xiao, C.L. Wu, Y.X. Gao et al. Prevalence of metabolic syndrome and its risk factors among rural adults in Nantong, China[J]. Sci. Rep. 6, 38089 (2016). https://doi.org/10.1038/srep38089CrossRefPubMedPubMedCentral

M. Aguilar, T. Bhuket, S. Torres et al. Prevalence of the metabolic syndrome in the United States, 2003-2012[J]. JAMA 313(19), 1973–4 (2015). https://doi.org/10.1001/jama.2015.4260CrossRefPubMed

A. Avila-Curiel, C. Galindo-Gomez, L. Juarez-Martinez et al. [Metabolic syndrome in children aged 6 to 12 years with obesity in public schools of seven municipalities in the State of Mexico][J]. Salud Publica Mex. 60(4), 395–403 (2018). https://doi.org/10.21149/8470CrossRefPubMed

Z.H. Wang, Z.Y. Zou, S. Wang et al. [Analysis of the epidemiological characteristics of metabolic syndrome among 10-16 adolescents in 7 provinces in China, 2012][J]. Zhonghua Yu Fang. Yi Xue Za Zhi 51(4), 295–299 (2017). https://doi.org/10.3760/cma.j.issn.0253-9624.2017.04.004CrossRefPubMed

J.M. Miller, M.B. Kaylor, M. Johannsson et al. Prevalence of metabolic syndrome and individual criterion in US adolescents: 2001-2010 National Health and Nutrition Examination Survey[J]. Metab. Syndr. Relat. Disord. 12(10), 527–32 (2014). https://doi.org/10.1089/met.2014.0055CrossRefPubMed

deboer M.D. Assessing and Managing the Metabolic Syndrome in Children and Adolescents[J]. Nutrients, 2019,11(8). https://doi.org/10.3390/nu11081788

L.X. Wang, S.L. Filipp, E.M. Urbina et al. Longitudinal associations of metabolic syndrome severity between childhood and young adulthood: The Bogalusa Heart Study[J]. Metab. Syndr. Relat. Disord. 16(5), 208–214 (2018). https://doi.org/10.1089/met.2017.0160CrossRefPubMedPubMedCentral

M.D. Deboer, M.J. Gurka, J.G. Woo et al. Severity of the metabolic syndrome as a predictor of type 2 diabetes between childhood and adulthood: the Princeton Lipid Research Cohort Study[J]. Diabetologia 58(12), 2745–52 (2015). https://doi.org/10.1007/s00125-015-3759-5CrossRefPubMedPubMedCentral

F.R. Guilherme, M. Nascimento, C.A. Molena-Fernandes et al. Comparison of different criteria in the prevalence of metabolic syndrome in students from Paranavai, Parana[J]. Rev. Paul. Pediatr. 37(3), 332–337 (2019). https://doi.org/10.1590/1984-0462/;2019;37;3;00007CrossRefPubMedPubMedCentral

10.

E. Kassi, P. Pervanidou, G. Kaltsas et al. Metabolic syndrome: definitions and controversies[J]. Bmc Med. 9, 48 (2011). https://doi.org/10.1186/1741-7015-9-48CrossRefPubMedPubMedCentral

11.

M. Rezapour, A. Shahesmaeili, A. Hossinzadeh et al. Comparison of lipid ratios to identify metabolic syndrome[J]. Arch. Iran. Med. 21(12), 572–577 (2018)PubMed

12.

A. Maturu, P. Dewitt, P.A. Kern et al. The triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio as a predictor of beta-cell function in African American women[J]. Metabolism 64(5), 561–5 (2015). https://doi.org/10.1016/j.metabol.2015.01.004CrossRefPubMed

13.

D.R. Matthews, J.P. Hosker, A.S. Rudenski et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man[J]. Diabetologia 28(7), 412–9 (1985). https://doi.org/10.1007/BF00280883CrossRefPubMed

14.

M. Matsuda, R.A. Defronzo, Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp[J]. Diabetes Care 22(9), 1462–70 (1999). https://doi.org/10.2337/diacare.22.9.1462CrossRefPubMed

15.

R.L. Hanson, R.E. Pratley, C. Bogardus et al. Evaluation of simple indices of insulin sensitivity and insulin secretion for use in epidemiologic studies[J]. Am. J. Epidemiol. 151(2), 190–8 (2000). https://doi.org/10.1093/oxfordjournals.aje.a010187CrossRefPubMed

16.

P. Zimmet, K.G. Alberti, F. Kaufman et al. The metabolic syndrome in children and adolescents - an IDF consensus report[J]. Pediatr. Diabetes 8(5), 299–306 (2007). https://doi.org/10.1111/j.1399-5448.2007.00271.xCrossRefPubMed

17.

K.G. Alberti, P. Zimmet, J. Shaw, Metabolic syndrome–a new world-wide definition. A Consensus Statement from the International Diabetes Federation[J]. Diabet. Med. 23(5), 469–80 (2006). https://doi.org/10.1111/j.1464-5491.2006.01858.xCrossRefPubMed

18.

G.S. Ma, C.Y. Ji, J. Ma et al. [Waist circumference reference values for screening cardiovascular risk factors in Chinese children and adolescents aged 7 - 18 years][J]. Zhonghua Liu Xing Bing. Xue Za Zhi 31(6), 609–15 (2010)PubMed

19.

C.Y. Ji, Report on childhood obesity in China (1)–body mass index reference for screening overweight and obesity in Chinese school-age children[J]. Biomed. Environ. Sci. 18(6), 390–400 (2005)PubMed

20.

F. Hadaegh, D. Khalili, A. Ghasemi et al. Triglyceride/HDL-cholesterol ratio is an independent predictor for coronary heart disease in a population of Iranian men[J]. Nutr. Metab. Cardiovasc Dis. 19(6), 401–8 (2009). https://doi.org/10.1016/j.numecd.2008.09.003CrossRefPubMed

21.

S.W. Farrell, C.E. finley, C.E. Barlow et al. Moderate to high levels of cardiorespiratory fitness attenuate the effects of triglyceride to high-density lipoprotein cholesterol ratio on coronary heart disease mortality in men[J]. Mayo Clin. Proc. 92(12), 1763–1771 (2017). https://doi.org/10.1016/j.mayocp.2017.08.015CrossRefPubMed

22.

G. Zoppini, C. Negri, V. Stoico et al. Triglyceride-high-density lipoprotein cholesterol is associated with microvascular complications in type 2 diabetes mellitus[J]. Metabolism 61(1), 22–9 (2012). https://doi.org/10.1016/j.metabol.2011.05.004CrossRefPubMed

23.

M.Y. lee, P.J. Hsiao, J.C. Huang et al. Associations between triglyceride/high-density lipoprotein cholesterol ratio and micro- and macroangiopathies in type 2 diabetes mellitus[J]. Endocr. Pr. 24(7), 615–621 (2018). https://doi.org/10.4158/EP-2017-0254CrossRef

24.

M. Aguirre, Y. Briceno, R. Gomez-Perez et al. Triglycerides/High density lipoprotein cholesterol ratio as a cardiometabolic risk marker in children and adolescents from Merida city, Venezuela[J]. Endocrinol. Diabetes Nutr. 65(2), 74–83 (2018). https://doi.org/10.1016/j.endinu.2017.10.010CrossRef

25.

H. Yeom, H.C. Kim, J.M. Lee et al. Triglyceride to high density lipoprotein cholesterol ratio among adolescents is associated with adult hypertension: the Kangwha study[J]. Lipids Health Dis. 17(1), 212 (2018). https://doi.org/10.1186/s12944-018-0861-yCrossRefPubMedPubMedCentral

26.

J. Liang, J. Fu, Y. Jiang et al. TriGlycerides and high-density lipoprotein cholesterol ratio compared with homeostasis model assessment insulin resistance indexes in screening for metabolic syndrome in the chinese obese children: a cross section study[J]. Bmc Pediatr. 15, 138 (2015). https://doi.org/10.1186/s12887-015-0456-yCrossRefPubMedPubMedCentral

27.

Y.T. Wondmkun, Obesity, insulin resistance, and type 2 diabetes: associations and therapeutic implications[J]. Diabetes Metab. Syndr. Obes. 13, 3611–3616 (2020). https://doi.org/10.2147/DMSO.S275898CrossRefPubMedPubMedCentral

28.

Z.I.A. Nur, M.Y. Jalaludin, M.Z.R. Wan et al. TG: HDL-C ratio is a good marker to identify children affected by obesity with increased cardiometabolic risk and insulin resistance[J]. Int. J. Endocrinol. 2019, 8586167 (2019). https://doi.org/10.1155/2019/8586167CrossRef

29.

M. Zhou, L. Zhu, X. Cui et al. The triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio as a predictor of insulin resistance but not of beta cell function in a Chinese population with different glucose tolerance status[J]. Lipids Health Dis. 15, 104 (2016). https://doi.org/10.1186/s12944-016-0270-zCrossRefPubMedPubMedCentral

30.

S.J. Kim-Dorner, P.A. Deuster, S.A. Zeno et al. Should triglycerides and the triglycerides to high-density lipoprotein cholesterol ratio be used as surrogates for insulin resistance?[J]. Metabolism 59(2), 299–304 (2010). https://doi.org/10.1016/j.metabol.2009.07.027CrossRefPubMed

31.

N.A. Iwani, M.Y. Jalaludin, R.M. Zin et al. Triglyceride to HDL-C ratio is associated with insulin resistance in overweight and obese children[J]. Sci. Rep. 7, 40055 (2017). https://doi.org/10.1038/srep40055CrossRefPubMedPubMedCentral

32.

V. hirschler, G. Maccallini, M. Sanchez et al. Association between triglyceride to HDL-C ratio and insulin resistance in indigenous Argentinean children[J]. Pediatr. Diabetes 16(8), 606–12 (2015). https://doi.org/10.1111/pedi.12228CrossRefPubMed

33.

S.A. Mostafa, M.J. Davies, D.H. Morris et al. The association of the triglyceride-to-HDL cholesterol ratio with insulin resistance in White European and South Asian men and women[J]. Plos ONE 7(12), e50931 (2012). https://doi.org/10.1371/journal.pone.0050931CrossRefPubMedPubMedCentral

34.

C. Giannini, N. Santoro, S. Caprio et al. The triglyceride-to-HDL cholesterol ratio: association with insulin resistance in obese youths of different ethnic backgrounds[J]. Diabetes Care 34(8), 1869–74 (2011). https://doi.org/10.2337/dc10-2234CrossRefPubMedPubMedCentral

35.

S. Dhuper, N.S. Bayoumi, Y.D. SHAH et al. Ethnic differences in lipid profiles of overweight, obese, and severely obese children and adolescents 6-19 years of age[J]. Child Obes. 13(3), 236–241 (2017). https://doi.org/10.1089/chi.2016.0208CrossRefPubMed

36.

C.N. Aslan, H. Yardimci, N. Koc et al. Triglycerides/high-density lipoprotein cholesterol is a predictor similar to the triglyceride-glucose index for the diagnosis of metabolic syndrome using International Diabetes Federation criteria of insulin resistance in obese adolescents: a cross-sectional study[J]. J. Pediatr. Endocrinol. Metab. 33(6), 777–784 (2020). https://doi.org/10.1515/jpem-2019-0310CrossRef

37.

N. Rodriguez-Gutierrez, T.M. Vanoye, E. Vazquez-Garza et al. Association of the triglyceride/high-density lipoprotein cholesterol index with insulin resistance in a pediatric population in Northeast Mexico[J]. Metab. Syndr. Relat. Disord. 18(7), 333–340 (2020). https://doi.org/10.1089/met.2020.0046CrossRefPubMed

Titel: Triglyceride to high-density lipoprotein cholesterol ratio in adolescence as a predictive marker of metabolic syndrome and obesity in early adulthood in China
verfasst von: Fang Zhou
Xiaoshi Sun
Juan Liu
Linlin Li
Ling Li
Ping Li
Publikationsdatum: 07.03.2022
Verlag: Springer US
Erschienen in: Endocrine / Ausgabe 2/2022
Print ISSN: 1355-008X
Elektronische ISSN: 1559-0100
DOI: https://doi.org/10.1007/s12020-022-03014-x

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

25.04.2024 | Hypotonie | Nachrichten

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Triglyceride to high-density lipoprotein cholesterol ratio in adolescence as a predictive marker of metabolic syndrome and obesity in early adulthood in China

Abstract

Objective

Methods

Results

Conclusion

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

Adjuvante Immuntherapie verlängert Leben bei RCC

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

Update Innere Medizin

Springer Medizin

Abstract

Objective

Methods

Results

Conclusion

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 2/2022

Mini-review: pump therapy in endocrinology & metabolism beyond diabetes

Response to the Letter to the Editor by Dr. Efremov and Alexeev “An alternative way to define hemodynamic instability in the pheochromocytoma surgery”

Beneficial effects of irisin in experimental paroxetine-induced hyperprolactinemia

Maternal serum leptin in the pregnant rat: fetal-placental implantation number and progesterone

Age-related risk for second breast cancer and gynecological malignant neoplasms after differentiated thyroid cancer

Anxiety and quality of life among papillary thyroid cancer patients awaiting final pathology results after surgery

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

Adjuvante Immuntherapie verlängert Leben bei RCC

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

Update Innere Medizin