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Cancer Immunology, Immunotherapy

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01.02.2008 | Commentary

Tumor stromal barriers to the success of adoptive T cell therapy

verfasst von: Vy Phan, Mary L. Disis

Erschienen in: Cancer Immunology, Immunotherapy | Ausgabe 2/2008

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Excerpt

Adoptive transfer of tumor competent T cells has long been studied as a therapeutic modality that may result in complete tumor eradication [1]. Indeed, T cells have the potential to home to all sites of metastatic disease no matter where the location and induce antigen-specific cell destruction. Theoretically, local clonal expansion of T cells in response to antigen will allow persistent killing over time until every cancer cell has been eradicated. No chemotherapeutic or biologic therapy developed to date has the ability to result in a persistent long lived anti-tumor effect. Unfortunately, the road to developing successful adoptive T cell therapy as a standard treatment for solid tumors has been littered with roadblocks. …

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Titel: Tumor stromal barriers to the success of adoptive T cell therapy
verfasst von: Vy Phan
Mary L. Disis
Publikationsdatum: 01.02.2008
Verlag: Springer-Verlag
Erschienen in: Cancer Immunology, Immunotherapy / Ausgabe 2/2008
Print ISSN: 0340-7004
Elektronische ISSN: 1432-0851
DOI: https://doi.org/10.1007/s00262-007-0356-6

Springer Medizin

Tumor stromal barriers to the success of adoptive T cell therapy

Excerpt

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Springer Medizin

Excerpt

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