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13.05.2016 | Original Article

TUSC3 suppresses glioblastoma development by inhibiting Akt signaling

verfasst von: Zhenfeng Jiang, Mian Guo, Xiangtong Zhang, Lifen Yao, Jia Shen, Guizhen Ma, Li Liu, Liwei Zhao, Chuncheng Xie, Hongsheng Liang, Haiyang Wang, Minwei Zhu, Li Hu, Yuanyuan Song, Hong Shen, Zhiguo Lin

Erschienen in: Tumor Biology | Ausgabe 9/2016

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Abstract

Glioblastoma multiform is one of the most common and most aggressive brain tumors in humans. The molecular and cellular mechanisms responsible for the onset and progression of GBM are elusive and controversial. The function of tumor suppressor candidate 3 (TUSC3) has not been previously characterized in GBM. TUSC3 was originally identified as part of an enzyme complex involved in N-glycosylation of proteins, but was recently implicated as a potential tumor suppressor gene in a variety of cancer types. In this study, we demonstrated that the expression levels of TUSC3 were downregulated in both GBM tissues and cells, and also found that overexpression of TUSC3 inhibits GBM cell proliferation and invasion. In addition, the effects of increased levels of methylation on the TUSC3 promoter were responsible for decreased expression of TUSC3 in GBM. Finally, we determined that TUSC3 regulates proliferation and invasion of GBM cells by inhibiting the activity of the Akt signaling pathway.

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Titel: TUSC3 suppresses glioblastoma development by inhibiting Akt signaling
verfasst von: Zhenfeng Jiang
Mian Guo
Xiangtong Zhang
Lifen Yao
Jia Shen
Guizhen Ma
Li Liu
Liwei Zhao
Chuncheng Xie
Hongsheng Liang
Haiyang Wang
Minwei Zhu
Li Hu
Yuanyuan Song
Hong Shen
Zhiguo Lin
Publikationsdatum: 13.05.2016
Verlag: Springer Netherlands
Erschienen in: Tumor Biology / Ausgabe 9/2016
Print ISSN: 1010-4283
Elektronische ISSN: 1423-0380
DOI: https://doi.org/10.1007/s13277-016-5072-4

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