Twin-mix anesthesia as pterygomandibular nerve block for surgical removal of impacted mandibular third molars

Various studies have endorsed the use of corticosteroids for minimizing the postoperative sequelae including trismus and swelling following surgical extraction of mandibular third molars. The exact dosage, mode of administration, and time of administration of corticosteroids varies in the literature. In this review, we propose and discuss a novel method of administration of corticosteroids for surgical removal of impacted mandibular third molars. The time and dose required to achieve a reliable clinical effect are also discussed. This article highlights and reviews the novel technique of administration of corticosteroid via intraspace injection, the composition of the drug used for this technique, the physical and chemical evaluation of the twin-mix solution, and comparative clinical trials with a control drug.