Erschienen in:
26.10.2020 | Letter to the Editor
Type 1 cryoglobulinemic neuropathy associated with lymphoplasmacytic lymphoma
verfasst von:
Yew Li Dang, Emma Foster, Moira Finlay, Andrew Evans
Erschienen in:
Acta Neurologica Belgica
|
Ausgabe 6/2021
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Excerpt
Cryoglobulinemia is characterized by the presence of serum immunoglobulins that precipitate at cold temperatures and dissolve at warmer temperatures [
1]. The incidence of cryoglobulinemia is 1:100,000, and more common in females and those aged 45–65 years old [
2]. Cryoglobulinemia is associated with infections, autoimmune disorders, and malignancies; the most common precipitant is hepatitis C infection [
1]. Cryoglobulinemia can cause systemic vasculitis, which may lead to vascular peripheral neuropathy (VPN). Vascular peripheral neuropathy is most frequently distributed in a distal sensory or sensorimotor pattern [
2]. Peripheral neuropathy has been commonly described in association with mixed cryoglobulinemia, and in association with hepatitis C infection [
3]. However, there are only limited reports of an association between VPN and type 1 (IgM paraproteinemia) cryoglobulinemia [
4]. …