Three days later, a repeat
18F-FDG PET/CT scan was conducted without any treatment in a warm environment, achieved by outfitting air-conditioned facilities with blankets and portable heaters, thereby ensuring optimal conditions for the procedure. The scan reveals the lack of the brown fat activity on axial (
a-
c) and maximum intensity projection (
d) images without a change in hypermetabolic activities of metastatic tumors (blue arrows). Based on his medical history, he presented absent sweating on the contralateral side of the arm, face, and chest, which may have been caused by damage to the sympathetic trunk during the previous surgery. Brown adipose tissue exhibits distinguishing features such as small cell size, multilocularity, a high mitochondrial count, enhanced vascularity, and substantial sympathetic noradrenergic innervation, in contrast to the more prevalent white adipose tissue [
1]. Brown adipose tissue contributes to thermoregulation in response to cold conditions, primarily attributed to its expression of uncoupling protein-1 (UCP1) located in the mitochondrial inner membrane. UCP1 plays a pivotal role in heat generation. While heat production typically results from ATP synthesis through oxidative phosphorylation in the mitochondrial respiratory chain, UCP1, involved in non-shivering thermogenesis, induces heat by uncoupling the mitochondrial respiratory chain [
2]. The regulation of thermogenesis involves the action of norepinephrine, which is released by the sympathetic nervous system and primarily interrelates with beta-adrenergic receptors located in brown adipocytes. Brown fat activity in
18F-FDG PET/CT is typically found in the cervical, supraclavicular, paravertebral, and mediastinal areas [
1,
3‐
6]. Denervation of sympathetic pathways can be caused by several etiologies, including a tumor mass, vascular dissection, and iatrogenic injury [
7‐
9]. Although there are several case reports available on unilateral patterns of brown fat activity in
18F-FDG PET/CT scans following surgical sympathetic denervation [
10‐
12], we report an interesting case showing the disappearance of brown fat activity on a repeat scan in warm conditions