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Current Oncology Reports

Erschienen in:

01.02.2018 | Neuro-oncology (S Nagpal, Section Editor)

Updates on Primary Central Nervous System Lymphoma

verfasst von: Lauren R. Schaff, Christian Grommes

Erschienen in: Current Oncology Reports | Ausgabe 2/2018

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Abstract

Purpose of Review

Primary central nervous system lymphoma (PCNSL) is an aggressive malignancy confined to the brain, spinal cord, leptomeninges, and eyes. Due to its rarity, there is a paucity of randomized trials and a varied approach to its management in the oncologic community. This review summarizes recent literature guiding current clinical practice.

Recent Findings

The presentation, work up, and management of PCNSL are discussed. Induction therapy incorporates a methotrexate-based chemotherapy regimen and is generally followed by a consolidation regimen including high dose chemotherapy (with or without autologous stem cell rescue). Whole brain radiation therapy (WBRT) is a potential additional consolidation strategy. Management of relapsed and refractory disease poses a special challenge due to poor outcomes. Immunotherapy and targeted treatments are promising novel strategies for recurrent/refractory patients.

Summary

Currently, there is little consensus in the management of PCNSL. Treatment recommendations should be tailored to the individual patient, with consideration for risk of neurotoxicity. New, exciting strategies are in development and when feasible, enrollment in a clinical trial should be considered.

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Titel: Updates on Primary Central Nervous System Lymphoma
verfasst von: Lauren R. Schaff
Christian Grommes
Publikationsdatum: 01.02.2018
Verlag: Springer US
Erschienen in: Current Oncology Reports / Ausgabe 2/2018
Print ISSN: 1523-3790
Elektronische ISSN: 1534-6269
DOI: https://doi.org/10.1007/s11912-018-0666-1

Springer Medizin

Updates on Primary Central Nervous System Lymphoma

Abstract

Purpose of Review

Recent Findings

Summary

Neu im Fachgebiet Onkologie

Erhöhte Mortalität bei postpartalem Brustkrebs

Hypertherme Chemotherapie bietet Chance auf Blasenerhalt

Ein Drittel der jungen Ärztinnen und Ärzte erwägt abzuwandern

Bessere Prognose mit links- statt rechtsseitigem Kolon-Ca.

Update Onkologie

Springer Medizin

Abstract

Purpose of Review

Recent Findings

Summary

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