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01.12.2014 | Original paper

Urinary bisphenol A-glucuronide and postmenopausal breast cancer in Poland

verfasst von: Britton Trabert, Roni T. Falk, Jonine D. Figueroa, Barry I. Graubard, Montserrat Garcia-Closas, Jolanta Lissowska, Beata Peplonska, Stephen D. Fox, Louise A. Brinton

Erschienen in: Cancer Causes & Control | Ausgabe 12/2014

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Abstract

Purpose

Concerns regarding a possible link between bisphenol A (BPA) and breast cancer have been mounting, but studies in human populations are lacking. We evaluated the association between the major urinary BPA metabolite [BPA-glucuronide (BPA-G)] and postmenopausal breast cancer risk in a large population-based case–control study conducted in two cities in Poland (2000–2003); we further explored the association of BPA-G levels with known postmenopausal breast cancer risk factors in our control population.

Methods

We analyzed creatinine-adjusted urinary BPA-G levels among 575 postmenopausal cases matched on age and study site to 575 controls without breast cancer using a recently developed assay. Odds ratios and 95 % confidence intervals were used to estimate the association between urinary BPA-G level and breast cancer using conditional logistic regression. Among controls, geometric mean BPA-G levels were compared across categories of breast cancer risk factors using linear regression models.

Results

There was no indication that increased BPA-G was associated with postmenopausal breast cancer (p-trend = 0.59). Among controls, mean BPA-G was higher among women reporting extended use of menopausal hormones, a prior screening mammogram, and residence in Warsaw. Other comparisons across strata of postmenopausal breast cancer risk factors were not related to differences in BPA-G.

Conclusions

Urinary BPA-G, measured at the time of diagnosis, is not linked to postmenopausal breast cancer.

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Titel: Urinary bisphenol A-glucuronide and postmenopausal breast cancer in Poland
verfasst von: Britton Trabert
Roni T. Falk
Jonine D. Figueroa
Barry I. Graubard
Montserrat Garcia-Closas
Jolanta Lissowska
Beata Peplonska
Stephen D. Fox
Louise A. Brinton
Publikationsdatum: 01.12.2014
Verlag: Springer International Publishing
Erschienen in: Cancer Causes & Control / Ausgabe 12/2014
Print ISSN: 0957-5243
Elektronische ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-014-0461-8

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Urinary bisphenol A-glucuronide and postmenopausal breast cancer in Poland