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01.12.2014 | Original paper | Ausgabe 12/2014

Cancer Causes & Control 12/2014

Urinary bisphenol A-glucuronide and postmenopausal breast cancer in Poland

Zeitschrift:
Cancer Causes & Control > Ausgabe 12/2014
Autoren:
Britton Trabert, Roni T. Falk, Jonine D. Figueroa, Barry I. Graubard, Montserrat Garcia-Closas, Jolanta Lissowska, Beata Peplonska, Stephen D. Fox, Louise A. Brinton
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1007/​s10552-014-0461-8) contains supplementary material, which is available to authorized users.

Abstract

Purpose

Concerns regarding a possible link between bisphenol A (BPA) and breast cancer have been mounting, but studies in human populations are lacking. We evaluated the association between the major urinary BPA metabolite [BPA-glucuronide (BPA-G)] and postmenopausal breast cancer risk in a large population-based case–control study conducted in two cities in Poland (2000–2003); we further explored the association of BPA-G levels with known postmenopausal breast cancer risk factors in our control population.

Methods

We analyzed creatinine-adjusted urinary BPA-G levels among 575 postmenopausal cases matched on age and study site to 575 controls without breast cancer using a recently developed assay. Odds ratios and 95 % confidence intervals were used to estimate the association between urinary BPA-G level and breast cancer using conditional logistic regression. Among controls, geometric mean BPA-G levels were compared across categories of breast cancer risk factors using linear regression models.

Results

There was no indication that increased BPA-G was associated with postmenopausal breast cancer (p-trend = 0.59). Among controls, mean BPA-G was higher among women reporting extended use of menopausal hormones, a prior screening mammogram, and residence in Warsaw. Other comparisons across strata of postmenopausal breast cancer risk factors were not related to differences in BPA-G.

Conclusions

Urinary BPA-G, measured at the time of diagnosis, is not linked to postmenopausal breast cancer.

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Zusatzmaterial
Supplementary material 1 (PDF 27 kb)
10552_2014_461_MOESM1_ESM.pdf
Supplementary material 2 (PDF 27 kb)
10552_2014_461_MOESM2_ESM.pdf
Supplementary material 3 (PDF 909 kb)
10552_2014_461_MOESM3_ESM.pdf
Literatur
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