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01.02.2010 | Original Article

Urinary collecting system invasion reflects adverse long-term outcome and is associated with simultaneous metastatic spread at the time of surgery and with multilocular dissemination during postsurgical follow-up in renal cell cancer

verfasst von: Sabine Brookman-Amissah, Matthias May, Knut Albrecht, Thomas Herrmann, Jan Roigas, Christian Peter Gilfrich, Sandra Pflanz, Sven Gunia

Erschienen in: World Journal of Urology | Ausgabe 1/2010

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Abstract

Objectives

To assess the prognostic implication of urinary collecting system invasion (CSI) in renal cell cancer (RCC).

Methods

Surveying a mean follow-up of 85 months, we investigated a cohort of 834 patients after radical (n = 710) or partial (n = 124) nephrectomy. At the time of surgery, 63 patients (7.6%) suffered from metastatic RCC. Various histopathologic parameters were analysed, and cancer specific survival (CSS) curves were individualized for each parameter. Furthermore, multivariate analysis was accomplished.

Results

Collecting system invasion was independently associated with a significant decline in CSS and was associated with simultaneous metastatic spread at the time of surgery and multilocular (involvement of at least two different organ systems) dissemination.

Conclusions

The prognostic implication of CSI in RCC appears to be more complex than expected. Therefore, pathologists should report on CSI to enable selection of patients to be investigated in prospective studies which are needed to clarify the prognostic role of CSI in RCC.

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Titel: Urinary collecting system invasion reflects adverse long-term outcome and is associated with simultaneous metastatic spread at the time of surgery and with multilocular dissemination during postsurgical follow-up in renal cell cancer
verfasst von: Sabine Brookman-Amissah
Matthias May
Knut Albrecht
Thomas Herrmann
Jan Roigas
Christian Peter Gilfrich
Sandra Pflanz
Sven Gunia
Publikationsdatum: 01.02.2010
Verlag: Springer-Verlag
Erschienen in: World Journal of Urology / Ausgabe 1/2010
Print ISSN: 0724-4983
Elektronische ISSN: 1433-8726
DOI: https://doi.org/10.1007/s00345-009-0426-9

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