Introduction
Methods
Statistical Analysis
Results
Clinical and Laboratory Characteristics of Patients with MODY2 and MODY3
T1D (n = 26) | MODY 2 (n = 29) | MODY 3 (n = 12) |
P
| |
---|---|---|---|---|
Age (years) | 22.88 ± 5.85 | 23.29 ± 11.54 | 21.75 ± 8.74 | 0.889 |
BMI (kg/m2) | 19.83 ± 3.18 | 19.47 ± 4.37 | 20.70 ± 1.65 | 0.623 |
HbA1c% | 9.52 ± 2.99 | 6.42 ± 0.35* | 8.31 ± 2.62# |
1.18×10
−5
|
Fasting glucose (mmol/L) | 9.58 ± 4.42 | 6.92 ± 0.58* | 8.26 ± 3.17 |
0.010
|
2-h glucose (mmol/L) | 15.57 ± 5.64 | 9.22 ± 1.78* | 13.46 ± 6.34# |
3.52×10
−5
|
Fasting C-peptide (ng/mL) | 0.29 ± 0.22 | 0.96 ± 0.42* | 1.34 ± 1.51* |
1.88×10
−4
|
2-h C-peptide (ng/mL) | 0.62 ± 0.57 | 3.93 ± 2.02* | 2.42 ± 1.35*# |
1.91×10
−9
|
hsCRP (mg/dL) | 1.22 ± 1.49 | 0.37 ± 0.39* | 0.18 ± 0.15* |
0.004
|
Total cholesterol (mmol/L) | 4.61 ± 0.81 | 4.12 ± 0.68* | 4.41 ± 0.93 | 0.098 |
Triglyceride (mmol/L) | 0.74 ± 0.32 | 0.65 ± 0.38 | 0.97 ± 0.43 | 0.051 |
HDL-C (mmol/L) | 1.28 ± 0.53 | 1.47 ± 0.25 | 1.32 ± 0.39 | 0.227 |
LDL-C (mmol/L) | 2.67 ± 0.79 | 2.24 ± 0.68 | 2.57 ± 0.86 | 0.125 |
Potential of Clinical Indices to Discriminate Among MODY Subtypes and T1D
Variables | T1D vs. MODY 2 | T1D vs. MODY 3 | MODY 2 vs. MODY 3 | |||
---|---|---|---|---|---|---|
OR (95% CI) |
P
| OR (95% CI) |
P
| OR (95% CI) |
P
| |
HbA1c% | 0.16 (0.04–0.61) |
0.007
| 0.81 (0.60–1.09) | 0.169 | 2.94 (1.15–7.56) |
0.025
|
Fasting glucose (mmol/L) | 0.69 (0.52–0.91) |
0.009
| 0.94 (0.76–1.15) | 0.526 | 1.57 (0.97–2.54) | 0.069 |
2-h glucose (mmol/L) | 0.58 (0.42–0.80) |
0.001
| 0.94 (0.82–1.08) | 0.375 | 1.47 (1.02–2.12) |
0.039
|
ln(fasting C-peptide) (ng/mL) | 870 (10.6–(7.2×104)) |
0.002
| 5.7×104 (1.9–(1.7×109)) |
0.037
| 2.31 (0.50–10.80) | 0.287 |
ln(2-h C-peptide) (ng/mL) | 2.7×104 (0.5–(1.4×109)) | 0.065 | 17.6 (2.0–152) |
0.009
| 0.19 (0.03–1.13) | 0.067 |
lnCRP (mg/dL) | 0.48 (0.25–0.94) |
0.033
| 0.19 (0.04–0.95) |
0.043
| 0.21 (0.05–0.86) |
0.031
|
Total cholesterol (mmol/L) | 0.37 (0.16–0.89) |
0.025
| 0.81 (0.32–2.04) | 0.650 | 1.70 (0.65–4.45) | 0.277 |
Triglyceride (mmol/L) | 0.30 (0.04–2.08) | 0.224 | 8.14 (0.86–77.50) | 0.068 | 12.47 (1.64–94.80) |
0.015
|
HDL-C (mmol/L) | 3.85 (0.73–20.48) | 0.113 | 1.48 (0.28–7.71) | 0.641 | 0.14 (0.01–2.04) | 0.149 |
LDL-C (mmol/L) | 0.36 (0.14–0.92) |
0.032
| 0.91 (0.36–2.35) | 0.852 | 1.98 (0.70–5.64) | 0.200 |