Background
Methods
Chemical ingredients database building
Active ingredients screening
OB prediction
DL evaluation
Caco-2 permeability
Target fishing
Disease targets database building
Network construction
Network construction method
Network topological feature set definition
Enrichment analysis
Results
Active compounds of Wumei pill
Target prediction and analysis
Uniprot ID | Gene symbol | Protein name | Degree |
---|---|---|---|
P04637 | TP53 | Cellular tumor antigen p53 | 71 |
P05412 | JUN | Transcription factor AP-1 | 68 |
P31749 | AKT1 | RAC-alpha serine/threonine-protein kinase | 67 |
P05231 | IL6 | Interleukin-6 | 64 |
P01375 | TNF | Tumor necrosis factor | 62 |
P15692 | VEGFA | Vascular endothelial growth factor A | 61 |
P00533 | EGFR | Epidermal growth factor receptor | 60 |
P42574 | CASP3 | Caspase 3 | 59 |
P28482 | MAPK1 | Mitogen-activated protein kinase 1 | 59 |
P10415 | BCL2 | Apoptosis regulator Bcl-2 | 59 |
P45983 | MAPK8 | Mitogen-activated protein kinase 8 | 59 |
P35354 | PTGS2 | Prostaglandin G/H synthase 2 | 59 |
P01133 | EGF | Pro-epidermal growth factor | 58 |
P01106 | MYC | Myc proto-oncogene protein | 57 |
P14780 | MMP9 | Matrix metalloproteinase-9 | 57 |
P01100 | FOS | Proto-oncogene c-Fos | 55 |
P01137 | TGFB1 | Transforming growth factor beta-1 | 51 |
GO biological process and KEGG pathway enrichment analysis
GO biological process enrichment analysis
KEGG pathway enrichment analysis
Term ID | Pathway name | Count | FDR |
---|---|---|---|
hsa04668 | TNF signaling pathway | 19 | 1.62E-14 |
hsa04620 | Toll-like receptor signaling pathway | 14 | 6.07E-08 |
hsa04066 | HIF-1 signaling pathway | 13 | 3.68E-07 |
hsa04210 | Apoptosis | 11 | 7.81E-07 |
hsa04115 | p53 signaling pathway | 11 | 1.73E-06 |
hsa04151 | PI3K-Akt signaling pathway | 20 | 1.87E-06 |
hsa04010 | MAPK signaling pathway | 17 | 7.26E-06 |
hsa04621 | NOD-like receptor signaling pathway | 9 | 1.05E-04 |
hsa04660 | T cell receptor signaling pathway | 11 | 1.22E-04 |
hsa04068 | FoxO signaling pathway | 12 | 1.51E-04 |
hsa04370 | VEGF signaling pathway | 9 | 2.42E-04 |
hsa04064 | NF-kappa B signaling pathway | 10 | 3.22E-04 |
hsa04071 | Sphingolipid signaling pathway | 11 | 5.19E-04 |
hsa04722 | Neurotrophin signaling pathway | 11 | 5.19E-04 |
hsa04060 | Cytokine-cytokine receptor interaction | 14 | 7.88E-04 |
hsa04915 | Estrogen signaling pathway | 10 | 9.83E-04 |
hsa04110 | Cell cycle | 10 | 0.006527 |