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01.06.2014 | Original Article

Vascular Smooth Muscle Cells in Cerebral Aneurysm Pathogenesis

verfasst von: Robert M. Starke, Nohra Chalouhi, Dale Ding, Daniel M. S. Raper, M. Sean Mckisic, Gary K. Owens, David M. Hasan, Ricky Medel, Aaron S. Dumont

Erschienen in: Translational Stroke Research | Ausgabe 3/2014

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Abstract

Vascular smooth muscle cells (SMC) maintain significant plasticity. Following environmental stimulation, SMC can alter their phenotype from one primarily concerned with contraction to a pro-inflammatory and matrix remodeling phenotype. This is a critical process behind peripheral vascular disease and atherosclerosis, a key element of cerebral aneurysm pathology. Evolving evidence demonstrates that SMCs and phenotypic modulation play a significant role in cerebral aneurysm formation and rupture. Pharmacological alteration of smooth muscle cell function and phenotypic modulation could provide a promising medical therapy to inhibit cerebral aneurysm progression. This study reviews vascular SMC function and its contribution to cerebral aneurysm pathophysiology.

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Titel: Vascular Smooth Muscle Cells in Cerebral Aneurysm Pathogenesis
verfasst von: Robert M. Starke
Nohra Chalouhi
Dale Ding
Daniel M. S. Raper
M. Sean Mckisic
Gary K. Owens
David M. Hasan
Ricky Medel
Aaron S. Dumont
Publikationsdatum: 01.06.2014
Verlag: Springer US
Erschienen in: Translational Stroke Research / Ausgabe 3/2014
Print ISSN: 1868-4483
Elektronische ISSN: 1868-601X
DOI: https://doi.org/10.1007/s12975-013-0290-1

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