Findings
Introduction
Materials and methods
Cell culture, IR irradiations, and drug treatments
Colony formation assay
Cell cycle distribution and cell growth analysis
Micronucleus assay
Results
The ATR inhibitor VE-821 radiosensitized human tumor cells irradiated with high LET carbon ions
8 h | 24 h | |||||
---|---|---|---|---|---|---|
D10 DMSO (Gy) | RBE | D10 DMSO (Gy) | RBE | |||
X-ray | Carbon | X-ray | Carbon | |||
HeLa | 5.47 | 2.67 | 2.05 | 6.66 | 2.62 | 2.54 |
U20S | 3.81 | 1.64 | 2.31 | 4.01 | 1.64 | 2.45 |
1BR-hTERT | 3.67 | 1.90 | 1.93 | 3.31 | 1.79 | 1.85 |
8 h | 24 h | |||||||
---|---|---|---|---|---|---|---|---|
D10 VE-821 (Gy) | SER | D10 VE-821 (Gy) | SER | |||||
X-ray | Carbon | X-ray | Carbon | X-ray | Carbon | X-ray | Carbon | |
HeLa | 4.52 | 1.96 | 1.21 | 1.36 | 3.45 | 1.50 | 1.93 | 1.74 |
U20S | 3.25 | 1.28 | 1.17 | 1.29 | 2.25 | 0.95 | 1.78 | 1.72 |
1BR-hTERT | 3.38 | 1.78 | 1.08 | 1.07 | 3.05 | 1.46 | 1.09 | 1.23 |