Background
Patients with multimorbidity represent a significant portion of the primary healthcare population [
1]. Although many definitions coexist in the literature, multimorbidity usually refers to the presence of multiple chronic or long-term conditions,that could include both physical and mental disease [
2]. People affected by multimorbidity are using social and health care services more intensively compared to the rest of the population. As well, there is an economic burden associated with multiple chronic conditions [
3], as multimorbidity has a large effect on patients’ daily life. More specifically, it reduces quality of life [
4] and increases mental illness such as anxiety [
5] and depression [
6,
7]. Patients with multiple chronic diseases experience important treatment burden in terms of understanding and self managing their chronic conditions, attending multiple appointments, and managing complex drug therapies [
8,
9]. In addition to a decrease in quality of life [
10], multimorbidity increased care fragmentation, burden (care burden and treatment) and affected relationships with relatives [
11‐
13]. This could lead to negative outcomes for patients and their caregivers [
13].
For healthcare providers, managing patients with multiple chronic conditions represents a challenge given the complexity and the intensity of interventions [
9,
14]. As an example, a minority of guidelines for patients with chronic disease consider multimorbidity as a norm in primary care settings. Most guidelines failed to discuss the burden of comprehensive treatment on patients or caregivers [
15]. This does not reflect the reality of primary care where there is a very high prevalence of multimorbidity and is it difficult for healthcare providers to apply multiple recommandations to the same patient. This complexity calls for greater healthcare provider expertise [
16], patient-centered care [
17] and interprofessional collaboration [
18]. Healthcare services have to be structured differently to reflect this intensity and integration of the interventions needed for complex patients [
19].
In most cases, suitable interventions for patients with multimorbidity are multifaceted because they have to address a variety of individual needs [
20]. Despite the specific needs of individual patients with multimorbidity [
21], most current research focuses on comprehensive care programs for people with single diseases [
22]. New emerging literature in primary care has put emphasis on two kinds of interventions that could inform optimal care: those based on a broad patient-centered care approach for patients with chronic diseases; and those specifically designed for patients with multimorbidity. Multimorbidity has been described above. Patient centered care is defined as a philosophy of care that encourages: a) shared control of the consultation decisions about interventions or management of the health problems of the patient, and/or b) a focus in the consultation on the patient as a whole person who has individual preferences situated within social contexts [
23]. Effectiveness of those two kinds of interventions in primary healthcare have been documented in systematic reviews [
20,
23,
24]. However the reviews did not report on specific elements associated with improved health-related outcomes in the patients; this represents an important gap in knowledge in addressing the needs of patients with multimorbidity [
25].
The aim of this review is to identify the specific elements of patient-centered care and multimorbidity interventions that are associated with positive outcomes for patients. The findings will support a reorientation of care from a single disease focus to a multimorbidity focus and centering not only on disease but also on the patient and context.
Method
In order to explore, map and synthesize the elements of patient-centered care interventions and interventions for patients with multimorbidity associated with positive health-related outcomes, a scoping review was conducted following the five stage approach suggested by Arksey and O’Malley’s (2005) [
26]. A summary of the stages is described below.
Stage 1: Identifying the research question
The research question for this scoping review was
Stage 2: Identifying relevant studies
To identify the relevant studies we reviewed four recent systematic reviews [
9,
23,
24,
27], which to our knowledge were the only ones available on the topic that were published between 2012 and 2016. These systematic reviews formed the basis of our search for original studies because they included studies published between 1990 and 2015. By providing information on care programs and their impact on patients with multimorbidity (De Bruin), assessing the clinical impact of patient-centered care interventions (Dwamena) and evaluating effectiveness of interventions specifically designed for patients with multimorbidity (Smith 2012; 2016), these syntheses were aligned with the research question of our scoping review.
Stage 3: Selecting studies
Two authors (MEP and MEM) independently assessed the eligibility of original studies. A three-step screening process was done: review of the abstract; review of the context, and review of the results. To be included in the mapping, studies had to be conducted in primary care and report at least one positive relationship with health-related outcomes.
As with all scoping reviews, the aim was to map the current literature on interventions with positive health-related outcomes, rather than to assess the quality of the particular studies chosen [
26,
28]. Quality appraisal of included literature is not required when performing a scoping review [
26,
29]. For this scoping review however, studies included had been assessed for quality to be included in their respective systematic reviews.
Stage 4: Charting the data
Two authors (MEP and MEM) conducted comprehensive reading and inductive coding for each original study. The research team generated a template for data extraction using NVivo 10.
NVivo 10 software was used to classify studies, to extract the date and to create categories and sub-categories. Synthesis and interpretation of the extracted data were done for the following: 1) type of intervention; 2) elements of the intervention; and 3) health-related positive outcomes. For this scoping review the term “element” is used to define an “operational element of intervention” or the “process more likely to be related to the outcomes”. Elements may have been clearly identified by the authors of the original studies or deduced from the content of the studies included.
Data were classified by author, year of publication, study location, study population, context of care, study aim and methodology. Interventions, elements and health-related outcomes that emerged from the data analysis were then classified. Frequent meetings were held to compare and adjust the coding and reach agreement. The findings were then merged and coding was discussed between the two authors. As a final step, the findings were shared and agreed upon by the whole research team.
Stage 5: Collating, summarizing and reporting the results
Co-interpretation and co-classification of types of intervention, elements of intervention and outcomes into common themes was performed by two authors (MEP and MEM.) They used the NVivo software to select and compile data and highlight the most frequently reported elements related to each intervention. Main interventions, their elements and outcomes were identified by consensus. The main interventions were classified according to a modified version of the Taxonomy of Interventions as reported by the Cochrane Effective Practice And Organisation of Care Review Group [
30] used by Smith et al. (2012) (Table
1) [
20].
Table 1
Modified version of Effective Practice and Organisation of Care Taxonomy
Patient-oriented interventions | For example, providing patient-oriented approaches, patient education or support for self management |
Professional interventions | For example, training healthcare providers to improve their competencies and knowledge related to patients’ needs and patient-centered care |
Organisational interventions | For example, supporting or providing case/care management decision process and evidence-based practice |
Discussion
Theme 1 – Key results
Results show that providing patient-oriented approaches, self-management support interventions (e.g. Providing educational resources and skills) and developing training for healthcare providers (e.g. Integrating care/case manager progressively within care setting) were the most frequent categories of interventions identified in this review with a potential to result in positive impacts for patients with chronic diseases. Therefore, those interventions, must be encouraged to address the concerns of patients with multimorbidity about their care and health. Care/case manager implementation was also found to be effective but less so. The care/case manager could play several roles that include helping patients identify and reach their goals and patient advocacy in their relationship with other health professionals [
84‐
87].
Theme 2 – Complex interactions (real world)
Elements of patient-centered interventions and interventions for patients with multimorbidity could be grouped into seven types of interventions linked to positive health-related outcomes. Those elements were likely synergistic and their combination favoured their success. The number of elements varied between four and eight depending on the intervention. The most important thing to understand is that patient-oriented interventions, professional interventions and organisational interventions present complex interactions and it is impossible to isolate one element to link it to a successful outcome. A single element cannot be linked to the success of the whole intervention. This reflects reality in practice and the need for pragmatic interventions adapted to patients, professionals and organizations.
Theme 3 – Where this review fits
This scoping review combined patient-centered interventions with interventions for patients with multimorbidity that were associated with positive health-related outcomes (see Fig.
2). This review adds to the work previously conducted by Dwamena et al. (2012) (patient-centered interventions), de Bruin et al. (2012) and Smith et al. (2012;2016) (interventions for patient with multimorbidity), by allowing a broader interpretation of the findings [
9,
23,
24,
27]. The combination of those studies reflects the actual interest in creating innovative and successful patient-centered interventions for patients with multimorbidity. By presenting the likely elements of successful interventions (see Fig.
2), this review has the potential to inform further development of innovative patient-centered interventions for persons with multimorbidity.
Strengths and limitations
This review used pragmatic and flexible methods to respond to the stated objectives. This inductive process is based on knowledge from qualitative and quantitative research and is strongly grounded in current concerns of healthcare providers in primary healthcare. Even if two of the authors of this scoping review are among the leading authors worldwide on the topics of patient-centered care (MS) and multimorbidity (MF) only one of the studies included in the systematic reviews that constitute the basis of this work were conducted by one of the authors [
81]. The presence of many authors and countries support the relevance of this topic.
Despite the strengths of this scoping review, certain limitations should be mentioned. The reader must be aware that all the included studies come from countries with strong primary healthcare systems and various contexts within these systems. Generalizing to other systems should be made with caution. We included only studies with positive patient’s related health outcomes to inform quickly the reader about: “what is the most effective?”. We were only interested in the positive effects in studies listed by Dwamena et al. (2012), de Bruin et al. (2012) and Smith et al. (2012;2016) and therefore only reported elements associated with positive effects. This is by no mean a guarantee that those elements would be associated with success if applied in a different context or environment. Including studies with negative findings may have counterbalanced the findings. From the studies included it was not possible to establish a clear relationship between individual elements and specific positive health-related outcomes as each study included several elements. In other words, the actual work does not permit us to isolate which specific elements of an intervention are the most effective because, in our view, it was the sum of elements included in the intervention that ensured positive effects. While some may call this a limitation, it reflects the reality of complex healthcare interventions.
Conclusion
This scoping review was motivated by the need to identify and implement innovative patient-centered interventions adapted to patients with multimorbidity. There is an evidence-base for innovations to ensure patient-centered care for persons with multimorbidity. The unique contribution of this work is in integrating literature related to interventions on patient centered care and care for patients with multimorbidity. For future research, this scoping review is a starting point and there is a need to conduct other research, such as systematic review or to summarize other relevant literature such as policy documents, grey literature and unpublished papers, to put forward innovative ways to include patients with multimorbidity in primary healthcare services. At this time, with this scoping review, any single outcome could be related to more than one intervention and element.
Clinicians must consider every component of patient-centered-care that will engage patients. Policy makers should review the evidence before implementing any new intervention in primary care and be sure to plan for evaluation whenever they implement a new intervention so that we can collectively learn from these experiences in various contexts. Further research is needed to explore which specific elements were related to which specific health-related outcomes. Finally, further research should include the innovative but less frequently reported elements found in interventions, such as establishing a long-term management plan between patients with chronic disease and care/case managers, supporting co-located interdisciplinary teams, engaging the patient as a partner and using telehealth technologies to improve health-related outcomes.
Acknowledgements
Thanks to Mireille Lambert M.A. for the coding validation and also to M. José Almirall, PhD and Tarek Bouhali MD MSc for reviewing the work.
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