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Erschienen in: Current Heart Failure Reports 2/2014

01.06.2014 | Management of Heart Failure (TE Meyer, Section Editor)

What to Do About Primary-Prevention Implantable Cardiac Defibrillators in Patients with Improved Ejection Fraction

verfasst von: Niyada Naksuk, Selcuk Adabag

Erschienen in: Current Heart Failure Reports | Ausgabe 2/2014

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Abstract

Approximately 20–40 % of heart failure patients with reduced ejection fraction (EF) demonstrate substantial improvements in their EF during follow-up. A subset of these patients who had originally received implantable cardioverter defibrillators (ICD) for the primary prevention of sudden cardiac death (i.e., patients with EF < 35 %) pose a challenge to cardiologists when they present with improvements in EF to above 35 % at the time of their battery depletion. Little is known about the risk of sudden cardiac death in these patients. Is the risk high enough to warrant the replacement of the ICD generator? In the following article, we review the available data on the risk of sudden cardiac death in these patients, and aim to assist the clinician and the patient in making informed decisions about whether the ICD therapy should be continued.
Literatur
1.
Zurück zum Zitat Bardy GH, Lee KL, Mark DB, Poole JE, Packer DL, Boineau R, et al. Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure. NEJM. 2005;352(3):225–37.PubMedCrossRef Bardy GH, Lee KL, Mark DB, Poole JE, Packer DL, Boineau R, et al. Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure. NEJM. 2005;352(3):225–37.PubMedCrossRef
2.
Zurück zum Zitat Moss AJ, Zareba W, Hall WJ, Klein H, Wilber DJ, Cannom DS, et al. Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction. NEJM. 2002;346(12):877–83.PubMedCrossRef Moss AJ, Zareba W, Hall WJ, Klein H, Wilber DJ, Cannom DS, et al. Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction. NEJM. 2002;346(12):877–83.PubMedCrossRef
3.••
Zurück zum Zitat Punnoose LR, Givertz MM, Lewis EF, Pratibhu P, Stevenson LW, Desai AS. Heart failure with recovered ejection fraction: a distinct clinical entity. J Card Fail. 2011;17(7):527–32. This is the first paper introducing the concept of heart failure with recovered ejection fraction in the literature. PubMedCrossRef Punnoose LR, Givertz MM, Lewis EF, Pratibhu P, Stevenson LW, Desai AS. Heart failure with recovered ejection fraction: a distinct clinical entity. J Card Fail. 2011;17(7):527–32. This is the first paper introducing the concept of heart failure with recovered ejection fraction in the literature. PubMedCrossRef
4.
Zurück zum Zitat Linton NW. Arrhythmia and left ventricular ejection fraction: once broken, always broken? Heart Rhythm. 2013;10(6):847–8.PubMedCrossRef Linton NW. Arrhythmia and left ventricular ejection fraction: once broken, always broken? Heart Rhythm. 2013;10(6):847–8.PubMedCrossRef
5.
Zurück zum Zitat Adabag AS, Luepker RV, Roger VL, Gersh BJ. Sudden cardiac death: epidemiology and risk factors. Nat Rev Cardiol. 2010;7(4):216–25.PubMedCrossRef Adabag AS, Luepker RV, Roger VL, Gersh BJ. Sudden cardiac death: epidemiology and risk factors. Nat Rev Cardiol. 2010;7(4):216–25.PubMedCrossRef
6.
Zurück zum Zitat Chugh SS, Reinier K, Teodorescu C, Evanado A, Kehr E, Al Samara M, et al. Epidemiology of sudden cardiac death: clinical and research implications. Prog Cardiovasc Dis. 2008;51(3):213–28.PubMedCentralPubMedCrossRef Chugh SS, Reinier K, Teodorescu C, Evanado A, Kehr E, Al Samara M, et al. Epidemiology of sudden cardiac death: clinical and research implications. Prog Cardiovasc Dis. 2008;51(3):213–28.PubMedCentralPubMedCrossRef
7.
Zurück zum Zitat Kadish A, Dyer A, Daubert JP, Quigg R, Estes NA, Anderson KP, et al. Prophylactic defibrillator implantation in patients with nonischemic dilated cardiomyopathy. NEJM. 2004 May 20;350(21):2151–8. Kadish A, Dyer A, Daubert JP, Quigg R, Estes NA, Anderson KP, et al. Prophylactic defibrillator implantation in patients with nonischemic dilated cardiomyopathy. NEJM. 2004 May 20;350(21):2151–8.
8.
Zurück zum Zitat Narayanan K, Reinier K, Uy-Evanado A, Teodorescu C, Chugh H, Marijon E, et al. Frequency and determinants of implantable cardioverter defibrillator deployment among primary prevention candidates with subsequent sudden cardiac arrest in the community. Circulation. 2013;128(16):1733–8.PubMedCrossRef Narayanan K, Reinier K, Uy-Evanado A, Teodorescu C, Chugh H, Marijon E, et al. Frequency and determinants of implantable cardioverter defibrillator deployment among primary prevention candidates with subsequent sudden cardiac arrest in the community. Circulation. 2013;128(16):1733–8.PubMedCrossRef
9.
Zurück zum Zitat Huikuri HV, Castellanos A, Myerburg RJ. Sudden death due to cardiac arrhythmias. NEJM. 2001;345(20):1473–82.PubMedCrossRef Huikuri HV, Castellanos A, Myerburg RJ. Sudden death due to cardiac arrhythmias. NEJM. 2001;345(20):1473–82.PubMedCrossRef
10.
Zurück zum Zitat Adabag S, Smith LG, Anand IS, Berger AK, Luepker RV. Sudden cardiac death in heart failure patients with preserved ejection fraction. J Card Fail. 2012;18(10):749–54.PubMedCrossRef Adabag S, Smith LG, Anand IS, Berger AK, Luepker RV. Sudden cardiac death in heart failure patients with preserved ejection fraction. J Card Fail. 2012;18(10):749–54.PubMedCrossRef
11.
Zurück zum Zitat Campbell RT, Jhund PS, Castagno D, Hawkins NM, Petrie MC, McMurray JJ. What have we learned about patients with heart failure and preserved ejection fraction from DIG-PEF, CHARM-preserved, and I-PRESERVE? J Am Coll Cardiol. 2012;60(23):2349–56. Campbell RT, Jhund PS, Castagno D, Hawkins NM, Petrie MC, McMurray JJ. What have we learned about patients with heart failure and preserved ejection fraction from DIG-PEF, CHARM-preserved, and I-PRESERVE? J Am Coll Cardiol. 2012;60(23):2349–56.
12.
Zurück zum Zitat Zile MR, Gaasch WH, Anand IS, Haass M, Little WC, Miller AB, et al. Mode of death in patients with heart failure and a preserved ejection fraction: results from the Irbesartan in Heart Failure With Preserved Ejection Fraction Study (I-Preserve) trial. Circulation. 2010;121(12):1393–405.PubMedCrossRef Zile MR, Gaasch WH, Anand IS, Haass M, Little WC, Miller AB, et al. Mode of death in patients with heart failure and a preserved ejection fraction: results from the Irbesartan in Heart Failure With Preserved Ejection Fraction Study (I-Preserve) trial. Circulation. 2010;121(12):1393–405.PubMedCrossRef
13.
Zurück zum Zitat Solomon SD, Wang D, Finn P, Skali H, Zornoff L, McMurray JJ, et al. Effect of candesartan on cause-specific mortality in heart failure patients: the Candesartan in Heart failure Assessment of Reduction in Mortality and morbidity (CHARM) program. Circulation. 2004;110(15):2180–3.PubMedCrossRef Solomon SD, Wang D, Finn P, Skali H, Zornoff L, McMurray JJ, et al. Effect of candesartan on cause-specific mortality in heart failure patients: the Candesartan in Heart failure Assessment of Reduction in Mortality and morbidity (CHARM) program. Circulation. 2004;110(15):2180–3.PubMedCrossRef
14.
Zurück zum Zitat Steimle AE, Stevenson LW, Fonarow GC, Hamilton MA, Moriguchi JD. Prediction of improvement in recent onset cardiomyopathy after referral for heart transplantation. J Am Coll Cardiol. 1994;23(3):553–9.PubMedCrossRef Steimle AE, Stevenson LW, Fonarow GC, Hamilton MA, Moriguchi JD. Prediction of improvement in recent onset cardiomyopathy after referral for heart transplantation. J Am Coll Cardiol. 1994;23(3):553–9.PubMedCrossRef
15.
Zurück zum Zitat McNamara DM, Starling RC, Cooper LT, Boehmer JP, Mather PJ, Janosko KM, et al. Clinical and demographic predictors of outcomes in recent onset dilated cardiomyopathy: results of the IMAC (Intervention in Myocarditis and Acute Cardiomyopathy)-2 study. J Am Coll Cardiol. 2011;58(11):1112–8.PubMedCrossRef McNamara DM, Starling RC, Cooper LT, Boehmer JP, Mather PJ, Janosko KM, et al. Clinical and demographic predictors of outcomes in recent onset dilated cardiomyopathy: results of the IMAC (Intervention in Myocarditis and Acute Cardiomyopathy)-2 study. J Am Coll Cardiol. 2011;58(11):1112–8.PubMedCrossRef
16.
Zurück zum Zitat Schliamser JE, Kadish AH, Subacius H, Shalaby A, Schaechter A, Levine J, et al. Significance of follow-up left ventricular ejection fraction measurements in the Defibrillators in Non-Ischemic Cardiomyopathy Treatment Evaluation trial (DEFINITE). Heart Rhythm. 2013;10(6):838–46. Schliamser JE, Kadish AH, Subacius H, Shalaby A, Schaechter A, Levine J, et al. Significance of follow-up left ventricular ejection fraction measurements in the Defibrillators in Non-Ischemic Cardiomyopathy Treatment Evaluation trial (DEFINITE). Heart Rhythm. 2013;10(6):838–46.
17.
Zurück zum Zitat Naksuk N, Saab A, Li JM, Florea V, Akkaya M, Anand IS, et al. Incidence of appropriate shock in implantable cardioverter-defibrillator patients with improved ejection fraction. J Card Fail. 2013;19(6):426–30. Naksuk N, Saab A, Li JM, Florea V, Akkaya M, Anand IS, et al. Incidence of appropriate shock in implantable cardioverter-defibrillator patients with improved ejection fraction. J Card Fail. 2013;19(6):426–30.
18.
Zurück zum Zitat Manfredi JA, Al-Khatib SM, Shaw LK, Thomas L, Fogel RI, Padanilam B, et al. Association between left ventricular ejection fraction post-cardiac resynchronization treatment and subsequent implantable cardioverter defibrillator therapy for sustained ventricular tachyarrhythmias. Circ Arrhythm Electrophysiol. 2013;6(2):257–64. Manfredi JA, Al-Khatib SM, Shaw LK, Thomas L, Fogel RI, Padanilam B, et al. Association between left ventricular ejection fraction post-cardiac resynchronization treatment and subsequent implantable cardioverter defibrillator therapy for sustained ventricular tachyarrhythmias. Circ Arrhythm Electrophysiol. 2013;6(2):257–64.
19.
Zurück zum Zitat Nerheim P, Birger-Botkin S, Piracha L, Olshansky B. Heart failure and sudden death in patients with tachycardia-induced cardiomyopathy and recurrent tachycardia. Circulation. 2004;110(3):247–52.PubMedCrossRef Nerheim P, Birger-Botkin S, Piracha L, Olshansky B. Heart failure and sudden death in patients with tachycardia-induced cardiomyopathy and recurrent tachycardia. Circulation. 2004;110(3):247–52.PubMedCrossRef
20.
Zurück zum Zitat Barra S, Agarwal S. Should an improvement in left ventricular systolic function preclude ICD generator replacement? Heart Rhythm. 2013;10(9):e76–7.PubMedCrossRef Barra S, Agarwal S. Should an improvement in left ventricular systolic function preclude ICD generator replacement? Heart Rhythm. 2013;10(9):e76–7.PubMedCrossRef
21.
Zurück zum Zitat Chad M House DN, William B Nelson, Dennis W Zhu. Normalization of Left Ventricular Ejection Fraction is Associated With the Absence of Appropriate Anti-Tachycardia Therapy in Patients Receiving Implantable Defibrillators for the Primary Prevention of Sudden Death Circulation. 2013;128 (Supl) (abst 15027). Chad M House DN, William B Nelson, Dennis W Zhu. Normalization of Left Ventricular Ejection Fraction is Associated With the Absence of Appropriate Anti-Tachycardia Therapy in Patients Receiving Implantable Defibrillators for the Primary Prevention of Sudden Death Circulation. 2013;128 (Supl) (abst 15027).
22.
Zurück zum Zitat Moss AJ, Schuger C, Beck CA, Brown MW, Cannom DS, Daubert JP, et al. Reduction in inappropriate therapy and mortality through ICD programming. NEJM. 2012;367(24):2275–83.PubMedCrossRef Moss AJ, Schuger C, Beck CA, Brown MW, Cannom DS, Daubert JP, et al. Reduction in inappropriate therapy and mortality through ICD programming. NEJM. 2012;367(24):2275–83.PubMedCrossRef
Metadaten
Titel
What to Do About Primary-Prevention Implantable Cardiac Defibrillators in Patients with Improved Ejection Fraction
verfasst von
Niyada Naksuk
Selcuk Adabag
Publikationsdatum
01.06.2014
Verlag
Springer US
Erschienen in
Current Heart Failure Reports / Ausgabe 2/2014
Print ISSN: 1546-9530
Elektronische ISSN: 1546-9549
DOI
https://doi.org/10.1007/s11897-014-0187-7

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