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Breast Cancer Research

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01.06.2011 | Viewpoint

Who is in the driver's seat in 8p12 amplifications? ZNF703 in luminal B breast tumors

verfasst von: Alexey V Bazarov, Paul Yaswen

Erschienen in: Breast Cancer Research | Ausgabe 3/2011

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Abstract

Two recent reports identify ZNF703 as an oncogene driving selection of frequent chromosome 8p12 amplifications in luminal B breast tumors. The estrogen-responsive ZNF703 gene encodes a transcriptional cofactor that, when overexpressed, induces cell proliferation and interferes with transforming growth factor beta signaling. In MCF7 cells, increased ZNF703 expression results in activation of genes involved in stem cell self-renewal - while in primary human mammary epithelial cells, ZNF703 increases the ratio of luminal to basal progenitors. Expression of the murine homolog of ZNF703 reduces cell adhesion and promotes metastasis. ZNF703 overexpression thus alters regulation of proliferation and differentiation in luminal B tumors.

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Titel: Who is in the driver's seat in 8p12 amplifications? ZNF703 in luminal B breast tumors
verfasst von: Alexey V Bazarov
Paul Yaswen
Publikationsdatum: 01.06.2011
Verlag: BioMed Central
Erschienen in: Breast Cancer Research / Ausgabe 3/2011
Elektronische ISSN: 1465-542X
DOI: https://doi.org/10.1186/bcr2873

Springer Medizin

Who is in the driver's seat in 8p12 amplifications? ZNF703 in luminal B breast tumors

Abstract

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Springer Medizin

Abstract

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