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European Journal of Nuclear Medicine and Molecular Imaging
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging 4/2008

01.04.2008 | Original article

Whole body [11C]-dihydrotetrabenazine imaging of baboons: biodistribution and human radiation dosimetry estimates

verfasst von: Rajan Murthy, Paul Harris, Norman Simpson, Ronald Van Heertum, Rudolph Leibel, J. John Mann, Ramin Parsey

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 4/2008

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Abstract

Purpose

Vesicular monoamine transporter type 2 abundance quantified using the radiotracer [11C]-dihydrotetrabenazine (DTBZ) has been used to study diagnosis and pathogenesis of dementia and psychiatric disorders in humans. In addition, it may be a surrogate marker for insulin-producing pancreatic beta cell mass, useful for longitudinal measurements using positron emission tomography to track progression of autoimmune diabetes. To support the feasibility of long-term repeated administrations, we estimate the biodistribution and dosimetry of [11C]-DTBZ in humans.

Methods

Five baboon studies were acquired using a Siemens ECAT camera. After transmission scanning, 165-210 MBq of [11C]-DTBZ were injected, and dynamic whole body emission scans were conducted. Time-activity data were used to obtain residence times and estimate absorbed radiation dose according to the MIRD model.

Results

Most of the injected tracer localized to the liver and the lungs, followed by the intestines, brain, and kidneys. The highest estimated absorbed radiation dose was in the stomach wall.

Conclusions

The largest radiation dose from [11C]-DTBZ is to the stomach wall. This dose estimate, as well as the radiation dose to other radiosensitive organs, must be considered in evaluating the risks of multiple administrations.
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Metadaten
Titel
Whole body [11C]-dihydrotetrabenazine imaging of baboons: biodistribution and human radiation dosimetry estimates
verfasst von
Rajan Murthy
Paul Harris
Norman Simpson
Ronald Van Heertum
Rudolph Leibel
J. John Mann
Ramin Parsey
Publikationsdatum
01.04.2008
Verlag
Springer Berlin Heidelberg
Erschienen in
European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 4/2008
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-007-0648-2

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