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Arthritis Research & Therapy

Erschienen in:

01.10.2009 | Review

Why are women predisposed to autoimmune rheumatic diseases?

verfasst von: Jacqueline E Oliver, Alan J Silman

Erschienen in: Arthritis Research & Therapy | Ausgabe 5/2009

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Abstract

The majority of autoimmune diseases predominate in females. In searching for an explanation for this female excess, most attention has focused on hormonal changes - both exogenous changes (for example, oral contraceptive pill) and fluctuations in endogenous hormone levels particularly related to menstruation and pregnancy history. Other reasons include genetic differences, both direct (influence of genes on sex chromosomes) and indirect (such as microchimerism), as well as gender differences in lifestyle factors. These will all be reviewed, focusing on the major autoimmune connective tissue disorders: rheumatoid arthritis, systemic lupus erythematosus and scleroderma.

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Titel: Why are women predisposed to autoimmune rheumatic diseases?
verfasst von: Jacqueline E Oliver
Alan J Silman
Publikationsdatum: 01.10.2009
Verlag: BioMed Central
Erschienen in: Arthritis Research & Therapy / Ausgabe 5/2009
Elektronische ISSN: 1478-6362
DOI: https://doi.org/10.1186/ar2825

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