Introduction
Methods
Study design and population
Outcome and predictor variables
Statistical analyses
Results
Preschool cohort (total n = 4718)a | Population controls (total n = 4122)a | p valueb | |||||||
---|---|---|---|---|---|---|---|---|---|
Median (IQR) | n/total n | % | (95% CI) | Median (IQR) | n/total n | % | (95% CI) | ||
Age in years | 45 (38–53) | 48 (39–57) | < 0.0001 | ||||||
Employment status (currently working) | 4265/4714 | 90 | (90–91) | 3310/4114 | 80 | (79–82) | < 0.0001 | ||
Education and income combined (mutually exclusive categories)c | < 0.0001 | ||||||||
University education and ≥ 30,000 SEK | 3804/4653 | 82 | (81–83) | 1774/4027 | 44 | (43–46) | |||
No university education and ≥ 30,000 SEK, or, university education and < 30,000 SEK | 849/4653 | 18 | (17–19) | 1528/4027 | 38 | (36–39) | |||
Lower than university education and < 30,000 SEK | 0/4653 | 0 | – | 725/4027 | 18 | (17–19) | |||
Smoking (ever smoked daily) | 1213/4703 | 26 | (25–27) | 1591/4089 | 39 | (37–40) | < 0.0001 | ||
Family history of hearing loss (< age 55) | 881/4702 | 19 | (18–20) | 755/4100 | 18 | (17–20) | 0.698 | ||
Ear infections (recurrent or prolonged) | 728/4690 | 16 | (14–17) | 580/4092 | 14 | (13–15) | 0.077 | ||
Tympanostomy tube (ever) | 191/3351 | 6 | (5–6) | 149/2743 | 5 | (5–6) | 0.651 | ||
Noisy leisure activities (≥ month or more) | 1179/4705 | 25 | (24–26) | 1199/4089 | 29 | (28–31) | < 0.0001 | ||
Hearing protection leisure time (always or often)d | 208/1164 | 18 | (16–20) | 233/1182 | 20 | (17–22) | 0.253 | ||
Loud music in headphones (≥ month, ≥ 75% vol.) | 358/2695 | 13 | (12–15) | 460/2458 | 19 | (17–20) | < 0.0001 | ||
Loud noise, can´t hear conversation (≥ 25% time) | 3368/4515 | 75 | (73–76) | 1176/3688 | 32 | (30–33) | < 0.0001 | ||
Loud noise, have to raise own voice (≥ 25% time) | 3376/4517 | 75 | (73–76) | 1078/3689 | 29 | (28–31) | < 0.0001 | ||
Hearing protection at work (always or often) | 123/4521 | 3 | (2–3) | 170/3698 | 5 | (4–5) | < 0.0001 | ||
Changed job/workplace due to noise (ever) | 312/4685 | 7 | (6–7) | 72/4034 | 2 | (1–2) | < 0.0001 | ||
Stressful working conditions
| |||||||||
Effort–reward imbalance (ERI) (ratio > 1) | 3725/4684 | 80 | (78–81) | 2383/4012 | 59 | (58–61) | < 0.0001 | ||
Emotional demands, COPSOQ (often or always) | 1699/4663 | 36 | (35–38) | 919/3985 | 23 | (22–24) | < 0.0001 | ||
Exposure strata among currently workinge | < 0.0001 | ||||||||
Unexposed to noise and stress | 384/4205 | 9 | (8–10) | 919/3250 | 29 | (27–30) | |||
Stress only (ERI or COPSOQ) | 831/4205 | 20 | (19–21) | 1483/3250 | 46 | (44–48) | |||
Noise only (exposed ≥ 25% of time at work) | 294/4205 | 7 | (6–8) | 163/3250 | 5 | (4–6) | |||
Both noise and stress exposure | 2696/4205 | 64 | (63–66) | 685/3250 | 21 | (20–22) |
Prevalence (%) | Risk ratio (RR)a (preschool/control) | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Preschool cohort (total n = 4718)b | Population controls (total n = 4122)b | Crude | Adjustedc | |||||||
n/total n | % | 95% CI | n/total n | % | 95% CI | RR | 95% CI | RR | 95% CI | |
Hearing loss
| ||||||||||
24–29 | 24/286 | 8 | (5–12) | 26/384 | 7 | (4–9) | 1.2 | (0.7–2.1) | 1.4 | (0.8–2.5) |
30–39 | 119/1114 | 11 | (9–13) | 57/725 | 8 | (6–10) |
1.4
| (1.0–1.8) |
1.7
| (1.2–2.4) |
40–49 | 269/1579 | 17 | (15–19) | 122/1048 | 12 | (10–14) |
1.5
| (1.2–1.8) |
1.7
| (1.4–2.1) |
50–59 | 356/1398 | 25 | (23–28) | 211/1147 | 18 | (16–21) |
1.4
| (1.2–1.6) |
1.6
| (1.3–1.9) |
60–65 | 101/293 | 34 | (29–40) | 172/749 | 23 | (20–26) |
1.5
| (1.2–1.8) |
1.8
| (1.4–2.3) |
All | 869/4670 | 19 | (17–20) | 588/4053 | 15 | (13–16) |
1.3
| (1.2–1.4) |
1.6
| (1.5–1.8) |
Tinnitus
| ||||||||||
24–29 | 30/288 | 10 | (7–14) | 48/387 | 12 | (9–16) | 0.8 | (0.6–1.3) | 1.0 | (0.6–1.8) |
30–39 | 145/1122 | 13 | (11–15) | 60/726 | 8 | (6–10) |
1.6
| (1.2–2.1) |
1.6
| (1.2–2.2) |
40–49 | 273/1580 | 17 | (15–19) | 114/1052 | 11 | (9–13) |
1.6
| (1.3–2.0) |
1.9
| (1.5–2.4) |
50–59 | 332/1397 | 24 | (22–26) | 183/1155 | 16 | (14–18) |
1.5
| (1.3–1.8) |
1.6
| (1.4–2.0) |
60–65 | 78/297 | 26 | (21–31) | 150/753 | 20 | (17–23) |
1.3
| (1.0–1.7) |
1.8
| (1.4–2.5) |
All | 858/4684 | 18 | (17–19) | 555/4073 | 14 | (13–15) |
1.3
| (1.2–1.5) |
1.7
| (1.5–1.9) |
Difficulty perceiving speech
| ||||||||||
24–29 | 94/285 | 33 | (28–38) | 72/375 | 19 | (15–23) |
1.7
| (1.3–2.2) |
1.8
| (1.4–2.5) |
30–39 | 429/1108 | 39 | (36–42) | 145/717 | 20 | (17–23) |
1.9
| (1.6–2.3) |
2.0
| (1.7–2.4) |
40–49 | 745/1576 | 47 | (45–50) | 253/1040 | 24 | (22–27) |
1.9
| (1.7–2.2) |
2.0
| (1.8–2.3) |
50–59 | 732/1380 | 53 | (50–56) | 354/1137 | 31 | (28–34) |
1.7
| (1.5–1.9) |
1.7
| (1.5–1.9) |
60–65 | 144/280 | 49 | (43–54) | 229/713 | 32 | (29–36) |
1.5
| (1.3–1.8) |
1.6
| (1.3–1.9) |
All | 2136/4629 | 46 | (45–48) | 1053/3982 | 26 | (25–28) |
1.7
| (1.6–1.9) |
1.9
| (1.7–2.0) |
Hyperacusis
| ||||||||||
24–29 | 77/287 | 27 | (22–32) | 62/386 | 16 | (12–20) |
1.7
| (1.2–2.3) |
1.7
| (1.2–2.4) |
30–39 | 420/1121 | 37 | (35–40) | 144/730 | 20 | (17–23) |
1.9
| (1.6–2.2) |
2.0
| (1.7–2.5) |
40–49 | 649/1585 | 41 | (39–43) | 198/1053 | 19 | (16–21) |
2.2
| (1.9–2.5) |
2.3
| (2.0–2.7) |
50–59 | 582/1402 | 42 | (39–44) | 213/1162 | 18 | (16–21) |
2.3
| (2.0–2.6) |
2.5
| (2.1–2.9) |
60–65 | 102/299 | 34 | (29–39) | 134/752 | 18 | (15–21) |
1.9
| (1.5–2.4) |
2.3
| (1.7–3.1) |
All | 1830/4694 | 39 | (38–40) | 751/4083 | 18 | (17–20) |
2.1
| (2.0–2.3) |
2.3
| (2.1–2.5) |
Sound-induced auditory fatigue
| ||||||||||
24–29 | 205/288 | 71 | (66–76) | 119/385 | 31 | (26–36) |
2.3
| (2.0–2.7) |
1.2
| (1.1–1.3) |
30–39 | 805/1126 | 71 | (69–74) | 232/724 | 32 | (29–35) |
2.2
| (2.0–2.5) |
2.4
| (2.1–2.7) |
40–49 | 1140/1585 | 72 | (70–74) | 340/1047 | 32 | (30–35) |
2.2
| (2.0–2.4) |
2.3
| (2.1–2.5) |
50–59 | 1002/1403 | 71 | (69–74) | 373/1155 | 32 | (30–35) |
2.2
| (2.0–2.4) |
1.5
| (1.4–1.6) |
60–65 | 201/295 | 68 | (63–73) | 239/735 | 33 | (29–36) |
2.1
| (1.8–2.4) |
2.2
| (1.9–2.6) |
All | 3353/4697 | 71 | (70–73) | 1303/4046 | 32 | (31–34) |
2.2
| (2.1–2.3) |
2.4
| (2.2–2.5) |
Prevalence (%) | Risk ratio (RR)b (preschool/control) | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Preschool cohort (total n = 4205)a | Population controls (total n = 3250)a | Crude | Adjustedc | |||||||
n/total n | % | (95% CI) | n/total n | % | (95% CI) | RR | (95% CI) | RR | (95% CI) | |
Hearing loss
| ||||||||||
Unexposed to noise and stress | 55/378 | 15 | (11–18) | 96/913 | 11 | (9–13) |
1.4
| (1.0–1.9) |
1.6
| (1.1–2.2) |
Stress only | 106/825 | 13 | (11–15) | 188/1469 | 13 | (11–15) | 1.0 | (0.8–1.3) | 1.2 | (0.97–1.6) |
Noise only | 60/293 | 20 | (16–25) | 30/160 | 19 | (13–25) | 1.1 | (0.7–1.6) | 1.3 | (0.8–2.2) |
Both noise and stress | 566/2676 | 21 | (20–23) | 131/673 | 19 | (16–22) | 1.1 | (0.9–1.3) |
1.4
| (1.1–1.7) |
All | 787/4172 | 19 | (18–20) | 445/3215 | 14 | (13–15) |
1.4
| (1.2–1.5) |
1.7
| (1.5–1.9) |
Tinnitus
| ||||||||||
Unexposed to noise and stress | 51/382 | 13 | (10–17) | 76/915 | 8 | (7–10) |
1.6
| (1.2–2.2) |
2.1
| (1.4–3.0) |
Stress only | 104/827 | 13 | (10–15) | 180/1476 | 12 | (11–14) | 1.0 | (0.8–1.3) | 1.2 | (0.9–1.5) |
Noise only | 48/294 | 16 | (12–21) | 17/161 | 11 | (6–15) | 1.5 | (0.9–2.6) | 1.6 | (0.8–2.9) |
Both noise and stress | 560/2679 | 21 | (19–22) | 130/681 | 19 | (16–22) | 1.1 | (0.9–1.3) |
1.4
| (1.2–1.7) |
All | 763/4182 | 18 | (17–19) | 403/3233 | 12 | (11–14) |
1.5
| (1.3–1.6) |
1.8
| (1.6–2.0) |
Difficulty perceiving speech
| ||||||||||
Unexposed to noise and stress | 101/380 | 27 | (22–31) | 155/917 | 17 | (14–19) |
1.6
| (1.3–2.0) |
1.6
| (1.3–2.0) |
Stress only | 279/825 | 34 | (31–37) | 368/1480 | 25 | (23–27) |
1.4
| (1.2–1.5) |
1.5
| (1.3–1.7) |
Noise only | 128/293 | 44 | (38–49) | 46/162 | 28 | (21–35) |
1.5
| (1.2–2.0) |
1.4
| (1.0–2.0) |
Both noise and stress | 1453/2675 | 54 | (53–56) | 312/682 | 46 | (42–49) |
1.2
| (1.1–1.3) |
1.3
| (1.1–1.4) |
All | 1961/4173 | 47 | (46–49) | 881/3241 | 27 | (26–29) |
1.7
| (1.6–1.8) |
1.9
| (1.7–2.0) |
Hyperacusis
| ||||||||||
Unexposed to noise and stress | 67/383 | 17 | (14–21) | 93/915 | 10 | (8–12) |
1.7
| (1.3–2.3) |
1.7
| (1.2–2.3) |
Stress only | 191/830 | 23 | (20–26) | 230/1477 | 16 | (14–17) |
1.5
| (1.2–1.8) |
1.5
| (1.2–1.8) |
Noise only | 76/292 | 26 | (21–31) | 26/162 | 16 | (10–22) |
1.6
| (1.1–2.4) | 1.3 | (0.8–2.1) |
Both noise and stress | 1305/2685 | 49 | (47–50) | 191/681 | 28 | (25–31) |
1.7
| (1.5–2.0) |
1.8
| (1.6–2.1) |
All | 1639/4190 | 39 | (38–41) | 540/3235 | 17 | (15–18) |
2.3
| (2.2–2.6) |
2.4
| (2.2–2.6) |
Sound-induced auditory fatigue
| ||||||||||
Unexposed to noise and stress | 98/384 | 26 | (21–30) | 88/915 | 10 | (8–12) |
2.7
| (2.0–3.4) |
2.7
| (2.0–3.6) |
Stress only | 370/828 | 45 | (41–48) | 368/1477 | 25 | (23–27) |
1.8
| (1.6–2.0) |
1.6
| (1.5–1.8) |
Noise only | 192/292 | 66 | (60–71) | 59/163 | 36 | (29–44) |
1.8
| (1.5–2.3) |
1.5
| (1.2–2.0) |
Both noise and stress | 2353/2690 | 87 | (86–89) | 463/683 | 68 | (64–71) |
1.3
| (1.2–1.4) |
1.3
| (1.2–1.4) |
All | 3013/4194 | 72 | (70–73) | 978/3238 | 30 | (29–32) |
2.4
| (2.3–2.5) |
1.9
| (1.8–1.9) |
Incidence rate (IR) (cases/1000 person-years) | Incidence rate ratio (IRR)b (preschool/control) | |||||||
---|---|---|---|---|---|---|---|---|
Preschool cohort (total n = 4718)c | Population controls (total n = 4122)c | Crude | ||||||
n/total n | IR | (95% CI) | n/total n | IR | (95% CI) | IRR | (95% CI) | |
Hearing loss
| ||||||||
Birth cohort 1989–1984 | 9/271 | 10.1 | (3.5–16.7) | 3/361 | 2.9 | (− 0.4–6.3) |
3.4
| (1.0–11.7) |
Birth cohort 1984–1974 | 67/1062 | 6.0 | (4.5–7.4) | 19/687 | 2.6 | (1.4–3.8) |
2.3
| (1.4–3.7) |
Birth cohort 1974–1964 | 210/1520 | 7.2 | (6.2–8.2) | 71/997 | 3.5 | (2.7–4.4) |
2.0
| (1.6–2.6) |
Birth cohort 1964–1954 | 284/1326 | 7.7 | (6.8–8.6) | 152/1088 | 4.8 | (4.1–5.6) |
1.6
| (1.3–1.9) |
Birth cohort 1954–1948 | 87/279 | 9.2 | (7.3–11.2) | 138/715 | 5.3 | (4.5–6.2) |
1.7
| (1.3–2.3) |
All | 657/4458 | 7.5 | (6.9–8.1) | 383/3848 | 4.5 | (4.0–4.9) |
1.7
| (1.5–1.9) |
Tinnitus
| ||||||||
Birth cohort 1989–1984 | 17/275 | 19.1 | (10.0–28.2) | 9/348 | 9.0 | (3.1–14.9) |
2.1
| (1.0–4.7) |
Birth cohort 1984–1974 | 109/1086 | 9.6 | (7.8–11.4) | 30/696 | 4.1 | (2.6–5.6) |
2.3
| (1.6–3.5) |
Birth cohort 1974–1964 | 251/1558 | 8.4 | (7.4–9.5) | 87/1025 | 4.2 | (3.3–5.1) |
2.0
| (1.7–2.5) |
Birth cohort 1964–1954 | 311/1376 | 8.0 | (7.1–8.9) | 159/1131 | 4.8 | (4.1–5.6) |
1.7
| (1.4–2.0) |
Birth cohort 1954–1948 | 73/292 | 7.1 | (5.6–8.7) | 134/737 | 5.0 | (4.1–5.8) |
1.4
| (1.1–1.9) |
All | 761/4587 | 8.4 | (7.8–9.0) | 419/3937 | 4.7 | (4.3–5.2) |
1.8
| (1.6–2.0) |
Difficulty perceiving speech
| ||||||||
Birth cohort 1989–1984 | 58/249 | 77.7 | (57.7–97.8) | 24/327 | 26.5 | (15.9–37.0) |
2.9
| (1.9–4.6) |
Birth cohort 1984–1974 | 347/1026 | 36.2 | (32.4–40.0) | 92/664 | 13.8 | (11.0–16.7) |
2.6
| (2.1–3.3) |
Birth cohort 1974–1964 | 676/1507 | 25.8 | (23.9–27.8) | 193/980 | 10.3 | (8.8–11.7) |
2.5
| (2.2–2.9) |
Birth cohort 1964–1954 | 675/1323 | 19.8 | (18.3–21.2) | 301/1084 | 10.0 | (8.8–11.1) |
2.0
| (1.7–2.3) |
Birth cohort 1954–1948 | 121/265 | 13.7 | (11.3–16.1) | 198/682 | 8.2 | (7.0–9.3) |
1.7
| (1.3–2.1) |
All | 1877/4370 | 23.6 | (22.5–24.7) | 808/3737 | 10.0 | (9.3–10.7) |
2.4
| (2.2–2.6) |
Hyperacusis
| ||||||||
Birth cohort 1989–1984 | 56/266 | 69.7 | (51.5–88.0) | 10/334 | 10.6 | (4.0–17.1) |
6.6
| (3.7–11.8) |
Birth cohort 1984–1974 | 350/1051 | 35.2 | (31.5–38.9) | 90/676 | 13.3 | (10.5–16.0) |
2.7
| (2.1–3.3) |
Birth cohort 1974–1964 | 586/1522 | 21.9 | (20.1–23.6) | 146/1001 | 7.4 | (6.2–8.6) |
2.9
| (2.5–3.5) |
Birth cohort 1964–1954 | 530/1350 | 14.8 | (13.6–16.1) | 179/1128 | 5.5 | (4.7–6.3) |
2.7
| (2.3–3.2) |
Birth cohort 1954–1948 | 92/289 | 9.2 | (7.4–11.1) | 114/732 | 4.3 | (3.5–5.0) |
2.2
| (1.7–2.8) |
All | 1614/4478 | 19.4 | (18.5–20.3) | 539/3871 | 6.2 | (5.7–6.8) |
3.1
| (2.8–3.4) |
Sound-induced auditory fatigue
d
| N/A | N/A |