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European Journal of Nuclear Medicine and Molecular Imaging
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging 1/2011

01.01.2011 | Original Article

18F-FDG PET and biomarkers for tumour angiogenesis in early breast cancer

verfasst von: Ashley M. Groves, Manu Shastry, Manuel Rodriguez-Justo, Anmol Malhotra, Raymondo Endozo, Timothy Davidson, Tina Kelleher, Kenneth A. Miles, Peter J. Ell, Mohammed R. Keshtgar

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 1/2011

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Abstract

Purpose

Tumour angiogenesis is an independent and strong prognostic factor in early breast carcinoma. We performed this study to investigate the ability of 18F-FDG to detect angiogenesis in early breast carcinoma using PET/CT.

Methods

Twenty consecutive patients with early (T1-T2) breast carcinoma were recruited prospectively for 18F-FDG PET/CT. The PET/CT data were used to calculate whole tumour maximum standardized uptake value (SUVmax) and mean standardized uptake value (SUVmean). All patients underwent subsequent surgery without prior chemotherapy or radiotherapy. The excised tumour underwent immunohistochemistry for vascular endothelial growth factor (VEGF), CD105 and glucose transporter protein 1 (GLUT1).

Results

The SUVmax showed the following correlation with tumour histology: CD105: r = 0.60, p = 0.005; GLUT1: r = 0.21, p = 0.373; VEGF: r = −0.16, p = 0.496. The SUVmean showed the following correlation with tumour histology: CD105: r = 0.65, p = 0.002; GLUT1: r = 0.34, p = 0.144; VEGF: r = −0.18, p = 0.443

Conclusion

18F-FDG uptake is highly significantly associated with angiogenesis as measured by the immunohistochemistry with CD105 for new vessel formation. Given that tumour angiogenesis is an important prognostic indicator and a predictor of treatment response, 18F-FDG PET may have a role in the management of primary breast cancer patients even in early-stage disease.
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Metadaten
Titel
18F-FDG PET and biomarkers for tumour angiogenesis in early breast cancer
verfasst von
Ashley M. Groves
Manu Shastry
Manuel Rodriguez-Justo
Anmol Malhotra
Raymondo Endozo
Timothy Davidson
Tina Kelleher
Kenneth A. Miles
Peter J. Ell
Mohammed R. Keshtgar
Publikationsdatum
01.01.2011
Verlag
Springer-Verlag
Erschienen in
European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 1/2011
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-010-1590-2

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