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Surgery Today
Erschienen in: Surgery Today 10/2016

28.12.2015 | Original Article

18F-Fluorodeoxyglucose positron emission tomography (18F-FDG PET) for the early detection of response to neoadjuvant chemotherapy for locally advanced rectal cancer

verfasst von: Junichi Nishimura, Junichi Hasegawa, Yoji Ogawa, Hideaki Miwa, Mamoru Uemura, Naotsugu Haraguchi, Taishi Hata, Hirofumi Yamamoto, Ichiro Takemasa, Tsunekazu Mizushima, Riichiro Nezu, Yuichiro Doki, Masaki Mori

Erschienen in: Surgery Today | Ausgabe 10/2016

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Abstract

Purpose

Early detection of a response to neoadjuvant chemotherapy for locally advanced rectal cancer may spare patients from additional toxic but ineffective chemotherapy. Using 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET), we evaluated tumor response prospectively in the early course of preoperative chemotherapy.

Methods

The subjects were 15 patients who received neoadjuvant chemotherapy (XELOX or XELOX plus bevacizumab) for locally advanced rectal cancer. Patients underwent 18F-FDG PET before chemotherapy, at the end of the first cycle of chemotherapy, and before surgical resection. Magnetic resonance imaging (MRI) was performed before chemotherapy, after the second cycle of chemotherapy, and before resection. After resection, the SUVmax and diameter were compared and graded according to the tumor regression grade (TRG).

Results

The TRG was assessed as TRG1 in one patient, TRG2 in five patients, and TRG3 in nine patients. We divided the patients into two groups: non-responders (NR) included the TRG1 and TRG2 patients, and responders (R) included the TRG3 patients. The tumor size before surgery was significantly smaller in the R group than in the NR group. The SUVmax at the end of the first cycle of chemotherapy and before surgical resection was significantly lower in the R group than in the NR group.

Conclusion

Performing 18F-FDG PET at the end of the first cycle of chemotherapy allowed us to predict the pathological response of locally advanced rectal cancer.
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Metadaten
Titel
18F-Fluorodeoxyglucose positron emission tomography (18F-FDG PET) for the early detection of response to neoadjuvant chemotherapy for locally advanced rectal cancer
verfasst von
Junichi Nishimura
Junichi Hasegawa
Yoji Ogawa
Hideaki Miwa
Mamoru Uemura
Naotsugu Haraguchi
Taishi Hata
Hirofumi Yamamoto
Ichiro Takemasa
Tsunekazu Mizushima
Riichiro Nezu
Yuichiro Doki
Masaki Mori
Publikationsdatum
28.12.2015
Verlag
Springer Japan
Erschienen in
Surgery Today / Ausgabe 10/2016
Print ISSN: 0941-1291
Elektronische ISSN: 1436-2813
DOI
https://doi.org/10.1007/s00595-015-1297-x

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